FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Equine Vet J / Comparative efficacy of inhaled albuterol between two hand-h...
Equine veterinary journal2011; 43(4); 393-398; doi: 10.1111/j.2042-3306.2010.00313.x

Comparative efficacy of inhaled albuterol between two hand-held delivery devices in horses with recurrent airway obstruction.

Abstract: Studies investigating the clinical efficacy of albuterol administered with the same propellant and commercially available delivery devices in horses with recurrent airway obstruction (RAO) are not currently available. Objective: To determine the efficacy of aerosolised albuterol administered to horses with RAO by means of 2 commercially available, hand-held delivery devices. Methods: Ten horses with RAO were kept in a dusty environment and fed mouldy hay to induce airway obstruction. Lung mechanics were measured before and after the procedure. ΔP(max) was measured 5 min after administration of 180 µg of albuterol from a pressurised metered dose inhaler, using an aerosol delivery device chosen randomly. This process was repeated every 5 min until maximal bronchodilation was achieved. After a 24 h washout period, lung mechanics data were again collected using the other aerosol delivery device. Results: Aerosolised albuterol induced a significant and rapid bronchodilation in the horses using both aerosol delivery devices. No statistically significant difference in pulmonary function was observed in response to albuterol therapy between the 2 devices. The dose required to achieve 50% of maximal bronchodilation was not statistically different between the 2 devices (173.35 ± 78.35 µg with Device 1 and 228.49 ± 144.99 µg with Device 2, P = 0.26). The decrease in lung resistance tended to be more pronounced after albuterol administration with Device 1 (P = 0.066). Conclusions: Aerosolised albuterol is an effective bronchodilator in horses with recurrent airway obstruction. There is no statistically significant difference between the 2 commercially available aerosol delivery devices in terms of efficacy. Conclusions: Aerosolised albuterol is effectively delivered using currently available devices leading to maximal bronchodilation in horses with RAO at an average dose of 540 µg.
© 2011 EVJ Ltd.
Get Full Text
Publication Date: 2011-03-11 PubMed ID: 21496081DOI: 10.1111/j.2042-3306.2010.00313.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Comparative Study
  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research studied the effectiveness of two commercially available devices for delivering albuterol, an aerosol medicine, to horses suffering from recurrent airway obstruction (RAO). The study found both devices to be equally effective in opening up the horses’ airways.

Objectives

  • The main goal of the study was to compare the clinical efficacy of two different commercially available devices used for administering albuterol to horses with RAO.
  • The study sought to determine if one device was more effective than the other in delivering the treatment and achieving bronchodilation (opening of the airways).

Methodology

  • The procedure involved keeping ten horses with RAO in a dusty environment and feeding them mouldy hay, in order to provoke airway obstruction.
  • The horses’ lung functions were measured before and after the induced obstruction, with the use of two different aerosol delivery devices.
  • The devices were used to administer doses of albuterol, and the effect on lung functions was measured repeatedly until maximum bronchodilation was achieved.
  • After a 24 hours washout period, the same process was repeated using the other device.

Results

  • The study found that both devices were significantly effective in administering the albuterol and causing rapid bronchodilation in the horses.
  • There were no significant differences found in the lung function changes between the two devices.
  • The dose required to achieve a 50% bronchodilation effect was also similar between the two devices (173.35 ± 78.35 µg with Device 1 and 228.49 ± 144.99 µg with Device 2).
  • The study also found a trend towards a more pronounced decrease in lung resistance after albuterol administration with Device 1.

Conclusions

  • The study concluded that aerosolised albuterol is an effective bronchodilator in horses with RAO and can be successfully administered with the current commercially available devices.
  • Neither device demonstrated superior efficacy over the other in terms of delivering this treatment.
  • Therefore, both devices could be used effectively in the treatment of horses with RAO using aerosolised albuterol.

Cite This Article

APA
Bertin FR, Ivester KM, Couëtil LL. (2011). Comparative efficacy of inhaled albuterol between two hand-held delivery devices in horses with recurrent airway obstruction. Equine Vet J, 43(4), 393-398. https://doi.org/10.1111/j.2042-3306.2010.00313.x

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 43
Issue: 4
Pages: 393-398

Researcher Affiliations

Bertin, F R
  • Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, Indiana, USA.
Ivester, K M
    Couëtil, L L

      MeSH Terms

      • Administration, Inhalation
      • Airway Obstruction / drug therapy
      • Airway Obstruction / veterinary
      • Albuterol / administration & dosage
      • Animals
      • Bronchodilator Agents / administration & dosage
      • Female
      • Horse Diseases / drug therapy
      • Horses
      • Male
      • Metered Dose Inhalers / standards
      • Metered Dose Inhalers / veterinary
      • Respiratory Function Tests / veterinary
      • Statistics, Nonparametric

      Citations

      This article has been cited 5 times.
      1. Secombe C, Adler A, Hosgood G, Raisis A, Mosing M. Can bronchoconstriction and bronchodilatation in horses be detected using electrical impedance tomography?. J Vet Intern Med 2021 Jul;35(4):2035-2044.
        doi: 10.1111/jvim.16152pubmed: 33977584google scholar: lookup
      2. Arroyo MG, Couëtil LL, Nogradi N, Kamarudin MM, Ivester KM. Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction.. J Vet Intern Med 2016 Jul;30(4):1333-7.
        doi: 10.1111/jvim.14320pubmed: 27282625google scholar: lookup
      3. Couëtil LL, Cardwell JM, Gerber V, Lavoie JP, Léguillette R, Richard EA. Inflammatory Airway Disease of Horses--Revised Consensus Statement.. J Vet Intern Med 2016 Mar-Apr;30(2):503-15.
        doi: 10.1111/jvim.13824pubmed: 26806374google scholar: lookup
      4. Nogradi N, Couetil LL, Messick J, Stochelski MA, Burgess JR. Omega-3 fatty acid supplementation provides an additional benefit to a low-dust diet in the management of horses with chronic lower airway inflammatory disease.. J Vet Intern Med 2015 Jan;29(1):299-306.
        doi: 10.1111/jvim.12488pubmed: 25307169google scholar: lookup
      5. Mazan MR, Lascola K, Bruns SJ, Hoffman AM. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol.. Can J Vet Res 2014 Jul;78(3):214-20.
        pubmed: 24982553
      Subscribe to our newsletter
      Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.