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Home / Equine Research Bank / J Vet Med Sci / Comparative endoscopic evaluation of normal and ulcerated ga...
The Journal of veterinary medical science2015; 77(4); 449-453; doi: 10.1292/jvms.14-0334

Comparative endoscopic evaluation of normal and ulcerated gastric mucosae in Thoroughbred foals.

Abstract: To contribute to early diagnosis and treatment of gastric ulcer of foals, we examined the gastric mucosa of healthy and affected foals using an endoscope. In healthy foals, the characteristic changes in the development of the squamous mucosa were seen mainly in the squamous mucosa, and maturation of the squamous mucosa in the greater curvature (GC-S) occurred more slowly than that of the squamous mucosa in the lesser curvature (LC-S). Epithelial desquamation in the LC-S and GC-S was observed between 6 and 90 days but was not observed in the LC-S at about 60 days, whereas it was observed in the GC-S until 90 days old. These findings suggest that there is a difference in the development of the gastric mucosa by region and that desquamation continues over a term longer than studies have reported in the past. In the affected foals, the minimum age at which gastric ulcer was observed was 4 days old. Gastric ulcers formed predominantly in the squamous mucosa (LC-S and GC-S) of foals with an immature mucosa before the weaning period, and the peak incidence occurred between 61 and 90 days old. The differences in the ulceration sites were considered to depend on the difference in the development (maturation) stage of the squamous mucosa. The grading score of the gastric ulcer increased with the growth of the affected foals. The gastric ulcer might be enhanced greatly by stress in the weaning period.
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Publication Date: 2015-01-15 PubMed ID: 25648790PubMed Central: PMC4427746DOI: 10.1292/jvms.14-0334Google Scholar: Lookup
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Summary

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This study examines the development and conditions of gastric mucosa in both healthy and afflicted Thoroughbred foals using an endoscope, aiming to improve early detection and treatment of gastric ulcers in foals. Findings noted disparities in development based on location and found that gastric ulcers, particularly within immature mucosa, could form as early as four days old.

Comparative Study Methodology

  • Utilizing endoscopy techniques, a comparative study was performed on the gastric mucosa of healthy and foal’s suffering from gastric ulcers.
  • As the study progressed, observed developments of mucosa were in the squamous mucosa, focusing especially on its maturation. The research found that the development in the greater curvature (GC-S) was slower than that of the lesser curvature (LC-S).
  • The study then proceeded to track epithelial desquamation in the LC-S and GC-S, noting appearances between 6 and 90 days.

Findings

  • The researchers discovered that there were developmental differences across various regions of gastric mucosa.
  • In addition, desquamation was seen to continue beyond the timeframes previously documented in other studies.
  • The minimum age for the observation of a gastric ulcer was just four days old in affected foals.
  • They also categorized gastric ulcers, which predominantly formed in the squamous mucosa (LC-S and GC-S) of foals with immature mucosa before the weaning period. The highest incidence of these ulcers was between 61 and 90 days old.
  • The ulceration site differences were believed to depend on the maturation stage of the squamous mucosa.
  • As the foals grew, the grading score of the gastric ulcer also increased.

Implications and Conclusions

  • It is suggested that stress during the weaning period might significantly enhance the gastric ulcer.
  • This research improves the understanding of gastric mucosa development in foals and the formation of gastric ulcers, aiding efforts in early detection and subsequent treatment.

Cite This Article

APA
Okai K, Taharaguchi S, Orita Y, Yokota H, Taniyama H. (2015). Comparative endoscopic evaluation of normal and ulcerated gastric mucosae in Thoroughbred foals. J Vet Med Sci, 77(4), 449-453. https://doi.org/10.1292/jvms.14-0334

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 77
Issue: 4
Pages: 449-453

Researcher Affiliations

Okai, Kazuhiko
  • Okai. Vet. Service, 7-54 Hokuseicho, Niikappu; Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyoudai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
Taharaguchi, Sadao
    Orita, Yasuhiro
      Yokota, Hiroshi
        Taniyama, Hiroyuki

          MeSH Terms

          • Aging
          • Animals
          • Animals, Newborn
          • Case-Control Studies
          • Endoscopy, Gastrointestinal / veterinary
          • Gastric Mucosa / pathology
          • Horse Diseases / pathology
          • Horses
          • Stomach Ulcer / pathology
          • Stomach Ulcer / veterinary

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          Citations

          This article has been cited 1 times.
          1. Hewetson M, Venner M, Volquardsen J, Sykes BW, Hallowell GD, Vervuert I, Fosgate GT, Tulamo RM. Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in weanling foals. Acta Vet Scand 2018 Apr 13;60(1):24.
            doi: 10.1186/s13028-018-0377-5pubmed: 29653546google scholar: lookup
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