Comparative immunology of allergic responses.
Abstract: Allergic responses occur in humans, rodents, non-human primates, avian species, and all of the domestic animals. These responses are mediated by immunoglobulin E (IgE) antibodies that bind to mast cells and cause release/synthesis of potent mediators. Clinical syndromes include naturally occurring asthma in humans and cats; atopic dermatitis in humans, dogs, horses, and several other species; food allergies; and anaphylactic shock. Experimental induction of asthma in mice, rats, monkeys, sheep, and cats has helped to reveal mechanisms of pathogenesis of asthma in humans. All of these species share the ability to develop a rapid and often fatal response to systemic administration of an allergen--anaphylactic shock. Genetic predisposition to development of allergic disease (atopy) has been demonstrated in humans, dogs, and horses. Application of mouse models of IgE-mediated allergic asthma has provided evidence for a role of air pollutants (ozone, diesel exhaust, environmental tobacco smoke) in enhanced sensitization to allergens.
Publication Date: 2014-11-20 PubMed ID: 25422854DOI: 10.1146/annurev-animal-022114-110930Google Scholar: Lookup
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Summary
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This research article investigates the commonality of allergic responses across various species, including humans, rodents, primates, birds, and a variety of domestic animals, showcasing that these reactions are facilitated by specific antibodies and can be manipulated by environmental factors.
Comparative Immunity and Allergic Responses
- The study delves into the occurrence of allergic responses in an array of species – humans, rodents, non-human primates, avian species, and different types of domestic animals. In all these beings, immune reactions to allergies are regulated by Immunoglobulin E (IgE) antibodies.
- IgE antibodies, when activated by an allergen, bind to mast cells – types of white blood cells – and stimulate the production or release of powerful chemicals called mediators.
- The research explores a range of medical conditions that are a result of these responses, including naturally occurring asthma in humans and cats, atopic dermatitis seen in humans, dogs, horses, and other species, food allergies, and anaphylactic shock.
Understanding Asthma through Cross-Species Study
- Experimental induction of asthma in mice, rats, monkeys, sheep, and cats has unveiled further information about the mechanisms behind the development of asthma in humans.
- All the species studied exhibit the potential to experience a rapid, and often fatal, response to systemic administration of an allergen called anaphylactic shock. This is a severe, whole-body allergic reaction that can occur within minutes of exposure to an allergen.
Genetic Influence and Environmental Factors
- The study also throws light on the genetic predisposition to the development of allergic disease, known as atopy, identified in humans, dogs, and horses. Atopy is the genetic tendency to develop allergic diseases.
- Mouse models of IgE-mediated allergic asthma have been utilized to understand the implications of environmental factors – more specifically air pollutants such as ozone, diesel exhaust, and environmental tobacco smoke – in the heightened sensitization to allergens.
Cite This Article
APA
Gershwin LJ.
(2014).
Comparative immunology of allergic responses.
Annu Rev Anim Biosci, 3, 327-346.
https://doi.org/10.1146/annurev-animal-022114-110930 Publication
Researcher Affiliations
- School of Veterinary Medicine, University of California, Davis, California 95616; email: ljgershwin@ucdavis.edu.
MeSH Terms
- Air Pollutants / immunology
- Allergens / immunology
- Animals
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Hypersensitivity / genetics
- Hypersensitivity / immunology
- Hypersensitivity / veterinary
- Immune System / physiology
- Immunoglobulin E / immunology
- Livestock
- Species Specificity
Citations
This article has been cited 12 times.- Dlugopolska D, Siwinska N, Noszczyk-Nowak A. Equine Asthma in a Comparative Perspective: Cardiovascular and Neurological Manifestations of Asthma Across Different Species. Animals (Basel) 2025 Aug 12;15(16).
- Li Y. The expression of MUC5AC in patients with rhinosinusitis: A systematic review and meta-analysis. Clin Transl Allergy 2024 Nov;14(11):e70003.
- Choi KS, Shin TS, Ahn G, Kim SH, Chun J, Lee M, Kim DH, Choi HG, Lee KD, Shim SY. Bioactivity-Guided Fraction from Viscera of Abalone, Haliotis discus hannai Suppresses Cellular Basophils Activation and Anaphylaxis in Mice. J Microbiol Biotechnol 2024 Feb 28;34(2):379-386.
- Zeng J, Lei L, Zeng Q, Yao Y, Wu Y, Li Q, Gao L, Du H, Xie Y, Huang J, Tan W, Lu J. Ozone Therapy Attenuates NF-κB-Mediated Local Inflammatory Response and Activation of Th17 Cells in Treatment for Psoriasis. Int J Biol Sci 2020;16(11):1833-1845.
- Satoh R, Jensen-Jarolim E, Teshima R. Understanding buckwheat allergies for the management of allergic reactions in humans and animals. Breed Sci 2020 Mar;70(1):85-92.
- Bobeck EA. NUTRITION AND HEALTH: COMPANION ANIMAL APPLICATIONS: Functional nutrition in livestock and companion animals to modulate the immune response. J Anim Sci 2020 Mar 1;98(3).
- Ugazio E, Tullio V, Binello A, Tagliapietra S, Dosio F. Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques. Molecules 2020 Jan 14;25(2).
- Félix NM, Gommeren K, Boysen S. Translational medicine between human and veterinary emergency and critical care medicine: a story meant to have a happy ending. Crit Care 2019 Nov 19;23(1):361.
- Kodavanti UP. Susceptibility Variations in Air Pollution Health Effects: Incorporating Neuroendocrine Activation. Toxicol Pathol 2019 Dec;47(8):962-975.
- Rosenberg HF, Druey KM. Modeling asthma: Pitfalls, promises, and the road ahead. J Leukoc Biol 2018 Jul;104(1):41-48.
- Einhorn L, Hofstetter G, Brandt S, Hainisch EK, Fukuda I, Kusano K, Scheynius A, Mittermann I, Resch-Marat Y, Vrtala S, Valenta R, Marti E, Rhyner C, Crameri R, Satoh R, Teshima R, Tanaka A, Sato H, Matsuda H, Pali-Schöll I, Jensen-Jarolim E. Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer. Allergy 2018 Jul;73(7):1436-1446.
- Marsella R, De Benedetto A. Atopic Dermatitis in Animals and People: An Update and Comparative Review. Vet Sci 2017 Jul 26;4(3).
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