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The Canadian veterinary journal = La revue veterinaire canadienne2015; 56(4); 387-392;

Comparison of cardiorespiratory variables in dorsally recumbent horses anesthetized with guaifenesin-ketamine-xylazine spontaneously breathing 50% or maximal oxygen concentrations.

Abstract: This study compared cardiorespiratory variables in dorsally recumbent horses anesthetized with guaifenesin-ketamine-xylazine and spontaneously breathing 50% or maximal (> 90%) oxygen (O2) concentrations. Twelve healthy mares were randomly assigned to breathe 50% or maximal O2 concentrations. Horses were sedated with xylazine, induced to recumbency with ketamine-diazepam, and anesthesia was maintained with guaifenesin-ketamine-xylazine to effect. Heart rate, arterial blood pressures, respiratory rate, lithium dilution cardiac output (CO), inspired and expired O2 and carbon dioxide partial pressures, and tidal volume were measured. Arterial and mixed-venous blood samples were collected prior to sedation (baseline), during 30 minutes of anesthesia, 10 minutes after disconnection from O2, and 30 minutes after standing. Shunt fraction, O2 delivery, and alveolar-arterial O2 partial pressures difference [P(A-a)O2] were calculated. Recovery times were recorded. There were no significant differences between groups in cardiorespiratory parameters or in P(A-a)O2 at baseline or 30 minutes after standing. Oxygen partial pressure difference in the 50% group was significantly less than in the maximal O2 group during anesthesia. Cette étude a comparé les variables cardiorespiratoires chez les chevaux en décubitus dorsal anesthésiés à l’aide de guaifénésine-kétamine-xylazine et respirant spontanément des concentrations de 50 % ou des concentrations maximales (> 90 %) d’oxygène (O). Douze juments en santé ont été assignées au hasard à la respiration de concentrations 50 % ou de concentrations maximales d’ O. Les chevaux ont été mis sous sédation avec de la xylazine, induits au décubitus à l’aide de kétamine-diazépam et l’anesthésie a été maintenue à l’aide de guaifénésine-kétamine-xylazine jusqu’à l’effet. Le rythme cardiaque, la pression artérielle, la fréquence respiratoire, le débit cardiaque par dilution au lithium, l’ O à l’inspiration et à l’expiration ainsi que les pressions partielles de gaz carbonique et le volume courant ont été mesurés. Des échantillons sanguins artériels et veineux mixtes ont été prélevés avant la sédation (données de référence), durant 30 minutes d’anesthésie, 10 minutes après le débranchement de l’oxygène et 30 minutes après s’être mis debout. La fraction du shunt, l’alimentation en O et la différence des pressions partielles d’ O alvéolaire-artérielle [P(A-a)O] ont été calculées. Les temps de réveil ont été consignés. Il n’y avait pas de différences significatives entre les groupes dans les paramètres cardiorespiratoires ou dans P(A-a)O aux données de référence ou 30 minutes après s’être mis debout. La différence entre la pression partielle de l’ O dans le groupe 50 % était significativement inférieure à celle du groupe avec des concentrations maximales d’ O durant l’anesthésie.(Traduit par Isabelle Vallières).
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Publication Date: 2015-04-02 PubMed ID: 25829559PubMed Central: PMC4357912
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper is a detailed comparison study of the effects of two differing oxygen concentrations on the cardiorespiratory variables in horses during anesthesia.

Study Design and Process

  • Twelve healthy female horses (mares) were used for this study. These subjects were divided into two groups, each allocated to inhale different oxygen concentrations. One group was to breathe 50% oxygen concentration, and the other was to breathe oxygen concentrations above 90% (referred to as the ‘maximal O2’ group).
  • The horses were sedated using xylazine, put into a recumbent (lying down) position with ketamine-diazepam, and the anesthetic effect was maintained with a combination of guaifenesin-ketamine-xylazine until the desired effect was achieved.
  • Various cardiorespiratory variables such as heart rate, arterial blood pressures, respiratory rate, tidal volume, and lithium dilution cardiac output were measured throughout the procedure. Moreover, inspired and expired oxygen and carbon dioxide partial pressures were also monitored.
  • Blood samples were taken from the animals at different stages – prior to sedation, throughout 30 minutes of anesthesia, 10 minutes post disconnection of oxygen, and half an hour after the horses had stood up following the anesthesia.

Findings and Conclusion

  • Calculations of shunt fraction, oxygen delivery, and alveolar-arterial oxygen partial pressures difference were carried out. The recovery times were also recorded as a part of the study.
  • Results showed no significant difference in cardiorespiratory parameters or in oxygen partial pressure differences at baseline or after 30 minutes of returning to standing between the two study groups.
  • The group exposed to 50% oxygen showed significantly less difference in oxygen partial pressure during the anesthesia phase compared to the high oxygen group. This marks the key finding of the study and indicates potential alterations in respiratory responses based on oxygen concentration during anesthesia in horses.

Cite This Article

APA
Karrasch NM, Hubbell JA, Aarnes TK, Bednarski RM, Lerche P. (2015). Comparison of cardiorespiratory variables in dorsally recumbent horses anesthetized with guaifenesin-ketamine-xylazine spontaneously breathing 50% or maximal oxygen concentrations. Can Vet J, 56(4), 387-392.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 56
Issue: 4
Pages: 387-392

Researcher Affiliations

Karrasch, Nicole M
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.
Hubbell, John A E
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.
Aarnes, Turi K
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.
Bednarski, Richard M
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.
Lerche, Phillip
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.

MeSH Terms

  • Anesthetics, Dissociative / administration & dosage
  • Anesthetics, Dissociative / pharmacology
  • Animals
  • Blood Pressure
  • Carbon Dioxide / blood
  • Cardiac Output / drug effects
  • Dose-Response Relationship, Drug
  • Expectorants / administration & dosage
  • Expectorants / pharmacology
  • Female
  • Guaifenesin / administration & dosage
  • Guaifenesin / pharmacology
  • Heart Rate / drug effects
  • Horses / physiology
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / pharmacology
  • Ketamine / administration & dosage
  • Ketamine / pharmacology
  • Oxygen / administration & dosage
  • Oxygen / blood
  • Posture
  • Respiration / drug effects
  • Xylazine / administration & dosage
  • Xylazine / pharmacology

References

This article includes 24 references
  1. McDonell WN, Kerr CL. Respiratory system. In: Tranquilli WJ, Thurmon JL, Grimm KA, editors. Lumb & Jones’ Veterinary Anesthesia. 4th ed. Hoboken, New Jersey: Wiley Blackwell; 2007. pp. 117–151.
  2. Gillespie JR, Tyler WS, Hall LW. Cardiopulmonary dysfunction in anesthetized, laterally recumbent horses.. Am J Vet Res 1969 Jan;30(1):61-72.
    pubmed: 5782568
  3. Whitehair KJ, Willits NH. Predictors of arterial oxygen tension in anesthetized horses: 1,610 cases (1992-1994).. J Am Vet Med Assoc 1999 Oct 1;215(7):978-81.
    pubmed: 10511864
  4. Steffey EP, Wheat JD, Meagher DM, Norrie RD, McKee J, Brown M, Arnold J. Body position and mode of ventilation influences arterial pH, oxygen, and carbon dioxide tensions in halothane-anesthetized horses.. Am J Vet Res 1977 Mar;38(3):379-82.
    pubmed: 15488
  5. Day TK, Gaynor JS, Muir WW 3rd, Bednarski RM, Mason DE. Blood gas values during intermittent positive pressure ventilation and spontaneous ventilation in 160 anesthetized horses positioned in lateral or dorsal recumbency.. Vet Surg 1995 May-Jun;24(3):266-76.
    pubmed: 7653042doi: 10.1111/j.1532-950x.1995.tb01330.xgoogle scholar: lookup
  6. Hubbell JA, Aarnes TK, Bednarski RM, Lerche P, Muir WW. Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses.. BMC Vet Res 2011 Jun 3;7:23.
    pmc: PMC3133541pubmed: 21639886doi: 10.1186/1746-6148-7-23google scholar: lookup
  7. Benson GJ, Manohar M, Kneller SK, Thurmon JC, Steffey EP. Radiographic characterization of diaphragmatic excursion in halothane-anesthetized ponies: spontaneous and controlled ventilation systems.. Am J Vet Res 1982 Apr;43(4):617-21.
    pubmed: 7041715
  8. Sorenson PR, Robinson NE. Postural effects on lung volumes and asynchronous ventilation in anesthetized horses.. J Appl Physiol Respir Environ Exerc Physiol 1980 Jan;48(1):97-103.
    pubmed: 7353982doi: 10.1152/jappl.1980.48.1.97google scholar: lookup
  9. Olson LE, Lai-Fook SJ. Pleural liquid pressure measured with rib capsules in anesthetized ponies.. J Appl Physiol (1985) 1988 Jan;64(1):102-7.
    pubmed: 3356626doi: 10.1152/jappl.1988.64.1.102google scholar: lookup
  10. Moens Y, Lagerweij E, Gootjes P, Poortman J. Influence of tidal volume and positive end-expiratory pressure on inspiratory gas distribution and gas exchange during mechanical ventilation in horses positioned in lateral recumbency.. Am J Vet Res 1998 Mar;59(3):307-12.
    pubmed: 9522950
  11. Robinson NE. The respiratory system. In: Muir WW, Hubbell JAE, editors. Equine Anesthesia. 2nd ed. St Louis, Missouri: Saunders Elsevier; 2009. pp. 11–36.
  12. Nyman G, Funkquist B, Kvart C, Frostell C, Tokics L, Strandberg A, Lundquist H, Lundh B, Brismar B, Hedenstierna G. Atelectasis causes gas exchange impairment in the anaesthetised horse.. Equine Vet J 1990 Sep;22(5):317-24.
    pubmed: 2226395doi: 10.1111/j.2042-3306.1990.tb04280.xgoogle scholar: lookup
  13. Wilson DV, Soma LR. Cardiopulmonary effects of positive end-expiratory pressure in anesthetized, mechanically ventilated ponies.. Am J Vet Res 1990 May;51(5):734-9.
    pubmed: 2186677
  14. Wettstein D, Moens Y, Jaeggin-Schmucker N, Böhm SH, Rothen HU, Mosing M, Kästner SB, Schatzmann U. Effects of an alveolar recruitment maneuver on cardiovascular and respiratory parameters during total intravenous anesthesia in ponies.. Am J Vet Res 2006 Jan;67(1):152-9.
    pubmed: 16426225doi: 10.2460/ajvr.67.1.152google scholar: lookup
  15. Anderson KJ, Harten JM, Booth MG, Kinsella J. The cardiovascular effects of inspired oxygen fraction in anaesthetized patients.. Eur J Anaesthesiol 2005 Jun;22(6):420-5.
    pubmed: 15991503doi: 10.1017/s0265021505000712google scholar: lookup
  16. Barker GF, Manzo ND, Cotich KL, Shone RK, Waxman AB. DNA damage induced by hyperoxia: quantitation and correlation with lung injury.. Am J Respir Cell Mol Biol 2006 Sep;35(3):277-88.
    pmc: PMC2643280pubmed: 16574945doi: 10.1165/rcmb.2005-0340ocgoogle scholar: lookup
  17. Cuvelliez SG, Eicker SW, McLauchlan C, Brunson DB. Cardiovascular and respiratory effects of inspired oxygen fraction in halothane-anesthetized horses.. Am J Vet Res 1990 Aug;51(8):1226-31.
    pubmed: 2201230
  18. Linton RA, Young LE, Marlin DJ, Blissitt KJ, Brearley JC, Jonas MM, O'Brien TK, Linton NW, Band DM, Hollingworth C, Jones RS. Cardiac output measured by lithium dilution, thermodilution, and transesophageal Doppler echocardiography in anesthetized horses.. Am J Vet Res 2000 Jul;61(7):731-7.
    pubmed: 10895891doi: 10.2460/ajvr.2000.61.731google scholar: lookup
  19. West JB. Blood flow and metabolism. In: West JB, editor. Respiratory Physiology: The Essentials. 8th ed. Baltimore, Maryland: Lippincott Williams and Wilkins; 2008. pp. 35–53.
  20. Staffieri F, Bauquier SH, Moate PJ, Driessen B. Pulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture.. Equine Vet J 2009 Nov;41(8):747-52.
    pubmed: 20095221doi: 10.2746/042516409x416198google scholar: lookup
  21. Crumley MN, McMurphy RM, Hodgson DS, Kreider SE. Effects of inspired oxygen concentration on ventilation, ventilatory rhythm, and gas exchange in isoflurane-anesthetized horses.. Am J Vet Res 2013 Feb;74(2):183-90.
    pubmed: 23363340doi: 10.2460/ajvr.74.2.183google scholar: lookup
  22. Schatzmann U, Tschudi P, Held JP, Muhlebach B. An investigation of the action and haemolytic effect of glyceryl guaiacolate in the horse.. Equine Vet J 1978 Oct;10(4):224-8.
    pubmed: 33040doi: 10.1111/j.2042-3306.1978.tb02266.xgoogle scholar: lookup
  23. Dobson A, Gleed RD, Meyer RE, Stewart BJ. Changes in blood flow distribution in equine lungs induced by anaesthesia.. Q J Exp Physiol 1985 Apr;70(2):283-97.
    pubmed: 3925493doi: 10.1113/expphysiol.1985.sp002909google scholar: lookup
  24. Sinclair SE, McKinney S, Glenny RW, Bernard SL, Hlastala MP. Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse.. J Appl Physiol (1985) 2000 Jun;88(6):2269-78.
    pubmed: 10846045doi: 10.1152/jappl.2000.88.6.2269google scholar: lookup

Citations

This article has been cited 2 times.
  1. Savvas I, Pavlidou K, Braun C, Schauvliege S, Staffieri F, Moens Y. Evaluation of the Effect of the Inspired Oxygen Fraction on Blood Oxygenation during Inhalant Anaesthesia in Horses: A Systematic Review with Meta-Analysis. Animals (Basel) 2021 Jul 30;11(8).
    doi: 10.3390/ani11082245pubmed: 34438703google scholar: lookup
  2. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
    doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
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