Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery.
Abstract: The effects of lidocaine combined with medetomidine or lidocaine alone on cardiovascular function during anaesthesia and their effects on recovery have not been thoroughly investigated in isoflurane-anaesthetised horses. Objective: To determine the effects of an intraoperative i.v. constant rate infusion of lidocaine combined with medetomidine (Group 1) or lidocaine (Group 2) alone on cardiovascular function and on the quality of recovery in 12 isoflurane-anaesthetised horses undergoing arthroscopy. Objective: The combination would depress cardiovascular function but improve the quality of recovery when compared to lidocaine alone in isoflurane-anaesthetised horses. Methods: Lidocaine (2 mg/kg bwt i.v. bolus followed by 50 microg/kg bwt/min i.v.) or lidocaine (same dose) and medetomidine (5 microg/kg bwt/h i.v.) was started 30 min after induction of anaesthesia. Lidocaine administration was discontinued 30 min before the end of surgery in both groups, whereas medetomidine administration was continued until the end of surgery. Cardiovascular function and quality of recovery were assessed. Results: Horses in Group 1 had longer recoveries, which were of better quality due to better strength and overall attitude during the recovery phase than those in Group 2. Arterial blood pressure was significantly higher in Group 1 than in Group 2 and this effect was associated with medetomidine. No significant differences in cardiac output, arterial blood gases, electrolytes and acid-base status were detected between the 2 groups. Conclusions: The combination of an intraoperative constant rate infusion of lidocaine and medetomidine did not adversely affect cardiovascular function in isoflurane-anaesthetised horses and improved the quality of recovery when compared to an intraoperative infusion of lidocaine alone.
Publication Date: 2010-05-22 PubMed ID: 20486974DOI: 10.1111/j.2042-3306.2010.00027.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research paper examines the comparative effects of administering a continual intravenous infusion of either solely lidocaine or a combination of lidocaine and medetomidine on cardiovascular function during anesthesia and quality of recovery in horses undergoing arthroscopy.
Objective of the Study
- The study aimed to evaluate whether the combination of lidocaine and medetomidine during isoflurane anesthesia depresses cardiovascular function in horses undergoing surgery. At the same time, it was hypothesized that this combination would improve the quality of recovery when compared to the administration of lidocaine alone.
Methodology of the Study
- Twelve isoflurane-anesthetized horses, undergoing arthroscopy were part of the study. They were divided into two groups: Group 1 was administered an infusion of lidocaine combined with medetomidine, and Group 2 was given lidocaine alone.
- Administration of lidocaine in both groups started 30 minutes after anesthesia induction and was discontinued 30 minutes before the end of surgery. For Group 1, medetomidine infusion continued until the end of surgery.
- Various parameters like cardiovascular function, arterial blood pressure, cardiac output, arterial blood gases, electrolytes, and acid-base status were assessed during the process.
Results of the Study
- The study found that horses in Group 1, who received lidocaine and medetomidine, had longer recoveries. However, these recoveries were of superior quality due to enhanced strength and overall attitude during the recovery phase than those in Group 2.
- Group 1 registered significantly higher arterial blood pressure, an effect associated with medetomidine. There were, however, no substantial differences in cardiac output, arterial blood gases, electrolytes, and acid-base status between the two groups.
Conclusions of the Study
- The research concluded that combining an intraoperative constant rate infusion of lidocaine and medetomidine did not adversely affect the cardiovascular function in isoflurane-anesthetized horses. Moreover, it enhanced the quality of recovery compared to sole lidocaine infusion.
Cite This Article
APA
Valverde A, Rickey E, Sinclair M, Rioja E, Pedernera J, Hathway A, Cruz A.
(2010).
Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery.
Equine Vet J, 42(3), 192-199.
https://doi.org/10.1111/j.2042-3306.2010.00027.x Publication
Researcher Affiliations
- Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
MeSH Terms
- Anesthesia Recovery Period
- Anesthesia, General / veterinary
- Anesthetics, General / administration & dosage
- Anesthetics, General / pharmacology
- Anesthetics, Inhalation / pharmacology
- Anesthetics, Local / pharmacology
- Animals
- Blood Pressure / drug effects
- Drug Therapy, Combination
- Female
- Heart Rate / drug effects
- Horses
- Infusions, Intravenous / veterinary
- Isoflurane / pharmacology
- Lidocaine / administration & dosage
- Lidocaine / pharmacology
- Male
- Medetomidine / administration & dosage
- Medetomidine / pharmacology
Citations
This article has been cited 5 times.- Vermedal H, Valverde A, Sears W. Effect of anesthesia duration on the quality of recovery in horses undergoing elective and emergency surgeries using the same anesthetic protocol. Can J Vet Res 2021 Jul;85(3):193-200.
- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
- Moran-Muñoz R, Valverde A, Ibancovichi JA, Acevedo-Arcique CM, Recillas-Morales S, Sanchez-Aparicio P, Osorio-Avalos J, Chavez-Monteagudo JR. Cardiovascular effects of constant rate infusions of lidocaine, lidocaine and dexmedetomidine, and dexmedetomidine in dogs anesthetized at equipotent doses of sevoflurane. Can Vet J 2017 Jul;58(7):729-734.
- Conde Ruiz C, Cruz Benedetti IC, Guillebert I, Portier KG. Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study. Front Vet Sci 2015;2:58.
- Henderson ARP, Valverde A, Koenig J, Sears W. Effects of anesthetic protocol, procedure, and recovery stall and interval on the quality of recovery in repeatedly anesthetized horses. Can J Vet Res 2025 Jan;89(1):17-25.
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