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Comparison of daily and monthly pyrantel treatment in yearling thoroughbreds and the protective effect of strategic medication of mares on their foals.
Abstract: Studies on a Thoroughbred breeding farm in Ohio were done to: (1) compare the effects of daily administration of pyrantel tartrate feed pellets with monthly administration of a pyrantel pamoate paste to yearling horses (21 January-3 September); (2) assess the effects of daily pyrantel tartrate given strategically in spring/summer to foaling mares (1 April-16 August) and given for a prolonged period to barren mares (21 January-3 September); (3) determine if strategic medication of foaling mares with daily pyrantel tartrate protected their foals until weaning. There were no differences in cyathostome egg counts, pasture larval counts, body condition scores, or body weights of yearlings treated with daily pyrantel tartrate or monthly pyrantel pamoate. Both treatments failed to maintain fecal egg counts of yearlings below 100 eggs per gram (epg), and mean counts exceeded 400 epg (pyrantel pamoate) and 700 epg (pyrantel tartrate) in August and September, resulting in a sharp, but moderate increase in pasture infectivity in October. By contrast, prolonged or strategic use of daily pyrantel tartrate in mature horses were each highly effective in reducing pasture contamination and infectivity with cyathostome eggs and larvae respectively. Strategic medication of foaling mares provided protection of their foals until weaning and first treatment of foals was delayed until after weaning when mean strongyle counts exceeded 100 epg. Treatment of weanlings with pyrantel pamoate had little effect on egg counts. A comparative anthelmintic study with ivermectin, oxibendazole, and pyrantel pamoate confirmed earlier studies showing reduced efficacy of anthelmintics in young horses.
Publication Date: 1994-10-01 PubMed ID: 7886924DOI: 10.1016/0304-4017(94)90059-0Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Comparative Study
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research article examines the effects of different dosages of pyrantel, a medication used to combat parasites in horses, on yearlings and mares in relation to protective effects on their foals. There was no significant difference noted in two different methods of dosage in the yearlings, while the medication effectively reduced contamination and parasite infection when strategically used in mature horses.
Comparison of Treatment Methods in Yearlings
- The study compared the effects of daily pyrantel tartrate feed pellets and a monthly administration of pyrantel pamoate paste on yearling horses, with the time frame ranging from January to September.
- Outcomes like cyathostome egg counts, body condition scores, body weights, and pasture larval counts showed no significant differences between the two treatment methods.
- However, both treatment methods failed to keep fecal egg counts below 100 eggs per gram (epg), with counts exceeding 400 and 700 epg for pyrantel pamoate and pyrantel tartrate respectively.
- This resulted in a sharp but moderate increase in pasture infectivity in October, indicating a possible failure of these treatment methods to control parasites.
Effects of Strategic Medication on Mares and Foals
- The study also examined the effects of strategic use of daily pyrantel tartrate in two scenarios: for foaling mares during the spring and summer and for barren mares over a longer period from January to September.
- The results showed that this approach was highly effective in both mature horses, significantly reducing pasture contamination and infectivity with cyathostome eggs and larvae.
- This treatment method provided protection for foaling mares’ offspring until weaning, delaying the need for the foals’ first treatment.
- However, the treatment of weanlings with pyrantel pamoate had little effect on controlling egg counts in these young horses.
Comparative Anthelmintic Study
- The research also conducted a comparative study of anthelmintics (drugs designed to combat parasites) including ivermectin, oxibendazole, and pyrantel pamoate.
- The results reconfirmed previous studies, indicating a reduced efficacy of these drugs in young horses compared to adult animals.
Cite This Article
APA
Herd RP, Majewski GA.
(1994).
Comparison of daily and monthly pyrantel treatment in yearling thoroughbreds and the protective effect of strategic medication of mares on their foals.
Vet Parasitol, 55(1-2), 93-104.
https://doi.org/10.1016/0304-4017(94)90059-0 Publication
Researcher Affiliations
- Department of Veterinary Preventive Medicine, Ohio State University, Columbus 43210.
MeSH Terms
- Administration, Oral
- Animals
- Anthelmintics / therapeutic use
- Benzimidazoles / therapeutic use
- Drug Administration Schedule
- Female
- Helminthiasis / prevention & control
- Helminthiasis, Animal
- Horse Diseases
- Horses
- Ivermectin / therapeutic use
- Parasite Egg Count
- Pyrantel Pamoate / administration & dosage
- Pyrantel Pamoate / therapeutic use
- Pyrantel Tartrate / administration & dosage
- Pyrantel Tartrate / therapeutic use
- Seasons
Citations
This article has been cited 2 times.- Corning S. Equine cyathostomins: a review of biology, clinical significance and therapy. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S1.
- Lyons ET, Tolliver SC, Rathgeber RA, Collins SS. Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically. Parasitol Res 2007 Feb;100(3):473-8.
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