Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane.
Abstract: This prospective clinical study compared the physiological effects of two commonly used anaesthetic induction techniques in horses maintained with halothane. One hundred horses admitted for elective surgery were randomly allocated to receive either guaiphenesin (to effect) and thiopentone (5 mg/kg), or detomidine (20 microg/kg) and ketamine (2 mg/kg) for the induction of anaesthesia after acepromazine premedication. Anaesthesia was maintained with halothane in oxygen. There were no significant differences in breed, age, sex, weight, type of surgery and duration of anaesthesia between the groups. Immediately after induction of anaesthesia heart rate was higher after guaiphenesin and thiopentone, and arterial blood pressure was higher after detomidine and ketamine. Thereafter hypotension, often necessitating an infusion of dobutamine, developed in both groups. Arterial blood gases and respiratory rates were similar in the two groups. There were no significant differences between the groups in the subjectively scored quality of induction and recovery, or in recovery time.
Publication Date: 1998-06-24 PubMed ID: 9637380DOI: 10.1136/vr.142.20.541Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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This research aims to compare how two different methods of anaesthetic induction impact the physiological conditions of horses that are maintained with halothane. The results revealed that there were no significant differences between the two methods in terms of quality of induction and recovery, recovery time, and specific physiological parameters.
Objective of the Study
- The goal of this study was to compare two prevalent techniques of anaesthetic induction in horses that are maintained with halothane. Halothane is a common general anesthetic used in veterinary medicine.
Tested Methods
- One hundred horses undergoing elective surgeries were randomly divided into two groups. One group was given guaiphenesin and thiopentone while the other was given detomidine and ketamine for anaesthetic induction.
- Prior to anaesthetic induction, all horses were premedicated with acepromazine, a tranquilizer and anti-nausea medication.
Variables Considered
- The breed, age, sex, weight of the horses, the type of surgery to be performed, and the duration of anaesthesia were all kept constant for both groups.
Results and Observations
- The results showed that immediately after induction, the heart rate was higher in horses given guaiphenesin and thiopentone, whereas the arterial blood pressure was higher in those given detomidine and ketamine.
- Hypotension – a condition of abnormally low blood pressure, developed in both groups after some time, necessitating a dobutamine infusion.
- With regards to arterial blood gases and respiratory rates, the two groups were similar.
- In terms of the quality of induction and recovery as well as recovery time, no significant differences were noted between the groups.
Conclusion
- In conclusion, both anaesthetic induction techniques yielded similar outcomes in horses maintained with halothane. Therefore, choosing either method does not significantly change the physiological response during and after the surgical procedure.
Cite This Article
APA
Bennett RC, Taylor PM, Brearley JC, Johnson CB, Luna SP.
(1998).
Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane.
Vet Rec, 142(20), 541-545.
https://doi.org/10.1136/vr.142.20.541 Publication
Researcher Affiliations
- Animal Health Trust, Newmarket, Suffolk.
MeSH Terms
- Analgesics / administration & dosage
- Anesthesia, General / veterinary
- Anesthetics, Dissociative / administration & dosage
- Anesthetics, Inhalation / administration & dosage
- Anesthetics, Intravenous / administration & dosage
- Animals
- Blood Pressure
- Drug Therapy, Combination
- Expectorants / administration & dosage
- Female
- Guaifenesin
- Halothane
- Heart Rate
- Horses / surgery
- Imidazoles
- Ketamine
- Male
- Prospective Studies
- Surgical Procedures, Operative / veterinary
- Thiopental
Citations
This article has been cited 2 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
- Tokushige H, Araki M, Kusano K, Arima D, Ito H, Yamazaki Y, Urayama S, Kambayashi Y, Tateno O, Ohta M. A retrospective comparison of induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.. J Equine Sci 2019 Jul;30(2):25-31.
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