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Home / Equine Research Bank / Am J Vet Res / Comparison of forced oscillation with the conventional metho...
American journal of veterinary research1999; 60(2); 174-180;

Comparison of forced oscillation with the conventional method for histamine bronchoprovocation testing in horses.

Abstract: To compare response of horses to histamine bronchoprovocation (HBP), using total respiratory resistance (Rrs) measured by forced oscillatory mechanics (FOM) with dynamic compliance (Cdyn) and pulmonary resistance (RL) measured by the esophageal balloon method. Methods: 10 horses with various degrees of airway reactivity. Methods: The 2 methods for measuring airway responses to HBP were performed on separate days. Endpoints compared were increase of 150 or 200% of baseline Rrs (PC150Rrs, PC200Rrs) and to 150% of baseline RL (PC150RL) or decrease to 65% of baseline Cdyn (PC65Cdyn). Frequency dependence of respiratory mechanics, using FOM, was evaluated, using the slope of Rrs over 1 to 3 Hz and the ratios of Rrs at 1 Hz to Rrs at 2 and 3 Hz (Rrs1Hz/Rrs2Hz, Rrs1Hz/Rrs3Hz) and of Rrs at 2 Hz to Rrs at 3 Hz (Rrs2Hz/Rrs3Hz). Effect of histamine on frequency dependence was assessed. Results: Correlation with PC65Cdyn was high for PC150Rrs (rs = 0.93) and PC200Rrs (rs = 0.96). Correlation between PC65Cdyn and PC150RL was weakly positive (rs = 0.61). The slope of Rrs over 1 to 3 Hz changed significantly between baseline (-0.07+/-0.09 cm H2O/L/s/Hz) and final histamine dose (-0.28+/-0.10 cm H2O/L/s/Hz). The Rrs1Hz/Rrs3Hz and Rrs2Hz/Rrs3Hz differed significantly (P < 0.05 between baseline [1.27+/-0.36 and 0.96+/-0.11, respectively] and final histamine dose [1.62+/-0.37 and 1.09+/-0.14, respectively]). Conclusions: Correlation between histamine-induced changes in respiratory mechanics, as measured by FOM and the pneumotachograph-esophageal balloon method, was good. The FOM results indicated frequency dependence of respiratory mechanics during HBP. Conclusions: A noninvasive method of measuring airway reactivity will facilitate routine evaluation of horses with suspected small airway disease and may be suitable for field studies.
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Publication Date: 1999-02-27 PubMed ID: 10048547
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates the comparability of two methods used for histamine bronchoprovocation testing in horses. The study finds a strong correlation between the results of forced oscillatory mechanics and the conventional esophageal balloon method, suggesting that the non-invasive method could be used effectively in the routine evaluation of small airway diseases in horses.

Methodology

  • The study involved 10 horses with varying degrees of airway reactivity.
  • The two methods for measuring airway responses, forced oscillatory mechanics (FOM) and the esophageal balloon method, were tested on different days.
  • The study focused on comparing endpoints including the increase of 150 or 200% of baseline total respiratory resistance (Rrs), the decrease to 65% of baseline dynamic compliance (Cdyn) and to 150% of baseline pulmonary resistance (RL).
  • The research also looked into the frequency dependence of respiratory mechanics, using FOM. The variables considered here were the slope of Rrs from 1 to 3 Hz and the ratios of Rrs at different Hz.
  • The influence of histamine on frequency dependence was also assessed.

Results

  • There was a high correlation between the 65% decrease in Cdyn and a 150 or 200% increase in Rrs: rs = 0.93 and rs = 0.96 respectively.
  • The correlation between a decrease in Cdyn and a 150% increase in RL was weakly positive (rs = 0.61).
  • The slope of Rrs changed significantly between the baseline and the final histamine dose.
  • The ratios of Rrs at 1 Hz to Rrs at 3 Hz and Rrs at 2 Hz to Rrs at 3 Hz differed significantly from the baseline to the final histamine dose.

Conclusions

  • Overall, there was a good correlation between the histamine-induced changes in respiratory mechanics as measured by both the FOM and the esophageal balloon method.
  • The FOM results indicated a frequency dependence of respiratory mechanics during histamine bronchoprovocation (HBP).
  • The research suggested that a noninvasive method of measuring airway reactivity such as FOM might be useful for routine evaluations of horses with suspected small airway disease and could be suitable for field studies.

Cite This Article

APA
Mazan MR, Hoffman AM, Manjerovic N. (1999). Comparison of forced oscillation with the conventional method for histamine bronchoprovocation testing in horses. Am J Vet Res, 60(2), 174-180.

Publication

American journal of veterinary research
ISSN: 0002-9645
NlmUniqueID: 0375011
Country: United States
Language: English
Volume: 60
Issue: 2
Pages: 174-180

Researcher Affiliations

Mazan, M R
  • Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Hoffman, A M
    Manjerovic, N

      MeSH Terms

      • Airway Resistance / physiology
      • Animals
      • Bronchial Hyperreactivity / physiopathology
      • Bronchial Hyperreactivity / veterinary
      • Bronchial Provocation Tests / methods
      • Bronchial Provocation Tests / veterinary
      • Dose-Response Relationship, Drug
      • Female
      • Histamine
      • Horse Diseases / physiopathology
      • Horses
      • Lung Diseases, Obstructive / physiopathology
      • Lung Diseases, Obstructive / veterinary
      • Male
      • Respiratory Mechanics / physiology
      • Statistics, Nonparametric

      Citations

      This article has been cited 10 times.
      1. Frippiat T, Art T, Tosi I. Airway Hyperresponsiveness, but Not Bronchoalveolar Inflammatory Cytokines Profiles, Is Modified at the Subclinical Onset of Severe Equine Asthma.. Animals (Basel) 2023 Aug 1;13(15).
        doi: 10.3390/ani13152485pubmed: 37570294google scholar: lookup
      2. Mahalingam-Dhingra A, Bedenice D, Mazan MR. Bronchoalveolar lavage hemosiderosis in lightly active or sedentary horses.. J Vet Intern Med 2023 May-Jun;37(3):1243-1249.
        doi: 10.1111/jvim.16692pubmed: 36975043google scholar: lookup
      3. Minuto J, Bedenice D, Ceresia M, Zaghloul I, Böhlke M, Mazan MR. Clinical effects and pharmacokinetics of nebulized lidocaine in healthy horses.. Front Vet Sci 2022;9:984108.
        doi: 10.3389/fvets.2022.984108pubmed: 36187809google scholar: lookup
      4. Mahalingam-Dhingra A, Mazan MR, Bedenice D, Ceresia M, Minuto J, Deveney EF. A CONSORT-guided, randomized, double-blind, controlled pilot clinical trial of inhaled lidocaine for the treatment of equine asthma.. Can J Vet Res 2022 Apr;86(2):116-124.
        pubmed: 35388235
      5. Dixon CE, Bedenice D, Mazan MR. Comparison of Flowmetric Plethysmography and Forced Oscillatory Mechanics to Measure Airway Hyperresponsiveness in Horses.. Front Vet Sci 2020;7:511023.
        doi: 10.3389/fvets.2020.511023pubmed: 33693040google scholar: lookup
      6. Lanz S, Brunner A, Graubner C, Marti E, Gerber V. Insect Bite Hypersensitivity in Horses is Associated with Airway Hyperreactivity.. J Vet Intern Med 2017 Nov;31(6):1877-1883.
        doi: 10.1111/jvim.14817pubmed: 28921663google scholar: lookup
      7. Léguillette R, Tohver T, Bond SL, Nicol JA, McDonald KJ. Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease.. J Vet Intern Med 2017 Jul;31(4):1193-1201.
        doi: 10.1111/jvim.14740pubmed: 28568169google scholar: lookup
      8. Burnheim K, Hughes KJ, Evans DL, Raidal SL. Reliability of breath by breath spirometry and relative flow-time indices for pulmonary function testing in horses.. BMC Vet Res 2016 Nov 28;12(1):268.
        doi: 10.1186/s12917-016-0893-3pubmed: 27894292google scholar: lookup
      9. Houtsma A, Bedenice D, Pusterla N, Pugliese B, Mapes S, Hoffman AM, Paxson J, Rozanski E, Mukherjee J, Wigley M, Mazan MR. Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study.. Multidiscip Respir Med 2015;10:33.
        doi: 10.1186/s40248-015-0030-3pubmed: 26535117google scholar: lookup
      10. Onmaz AC, Stoklas-Schmidt C, van den Hoven R. Daily variability of forced oscillometry parameters in horses suffering recurrent airway obstruction, a pilot study.. Vet Res Commun 2013 Mar;37(1):11-7.
        doi: 10.1007/s11259-012-9541-ypubmed: 23065455google scholar: lookup
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