Comparison of progesterone and progesterone + oestrogen on total and specific uterine proteins in pony mares.
Abstract: Eight ovariectomized pony mares were used to test the effect of various doses of progesterone (0, 50, 150, 450 mg/day, in oil, i.m., for 10 days) on progesterone and LH in the peripheral circulation, and on total protein and uteroferrin in uterine secretions. Progesterone increased uteroferrin, but there were no differences amongst doses of progesterone. Progesterone treatment decreased LH, and tended to increase total protein. Eighteen ovariectomized mares were given vehicle, oestradiol (10 mg/day, in oil, i.m.), progesterone or progesterone + oestradiol for 28 days. Both the last two steroid treatments significantly increased total protein and uteroferrin in the uterine secretions, compared to vehicle or oestradiol alone. Progesterone + oestradiol increased uteroferrin, but not total protein compared to progesterone. Nine ovariectomized progesterone-primed mares were used to compare systemic and intraluminal administration of oestradiol. There were no differences between routes of administration of oestradiol. In conclusion, administration of progesterone increased total protein and uteroferrin in uterine secretions, and progesterone + oestradiol increased them further.
Publication Date: 1987-01-01 PubMed ID: 3479587
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research paper studied the effects of progesterone and a combination of progesterone and oestrogen on pony mares’ uterine secretions, specifically on total protein and uteroferrin levels.
Study Setup and Procedure
- A total of 8 ovariectomized (ovaries removed) pony mares were used in the study to examine the effects of different doses of progesterone (0, 50, 150, 450 mg/day, administered through an intramuscular oil injection, for 10 days).
- The levels of progesterone and Luteinizing Hormone (LH) in the peripheral bloodstream and the quantity of total protein and uteroferrin in uterine secretions were studied.
- In addition, eighteen other ovariectomized mares were given a controlled substance (vehicle), oestradiol (10 mg/day, intramuscular oil injection), progesterone, or a combination of progesterone and oestradiol for 28 days to observe their effects.
- A group of nine ovariectomized mares, which had been primed with progesterone, were used to compare the effects of systemic and intraluminal administration of oestradiol.
Observations and Results
- The administration of progesterone led to an increase in uteroferrin, irrespective of the dosages given.
- Progesterone dosage also showed a decrease in LH and revealed a tendency to raise the total protein level.
- The treatments involving progesterone and the combination of progesterone and oestradiol significantly raised the quantity of total protein and uteroferrin in uterine secretions when compared to the controlled substance or oestradiol alone.
- When compared to this progesterone-treatment, the combined dosage of progesterone and oestradiol raised uteroferrin but did not notably affect total protein levels.
- No differences were observed in the results from the systemic and intraluminal administration of oestradiol.
Conclusion
- The report concludes that administering progesterone heightened the total protein and uteroferrin levels in uterine secretions.
- Moreover, the combination treatment of progesterone and oestradiol could marginally further increase these levels.
Cite This Article
APA
McDowell KJ, Sharp DC, Grubaugh W.
(1987).
Comparison of progesterone and progesterone + oestrogen on total and specific uterine proteins in pony mares.
J Reprod Fertil Suppl, 35, 335-342.
Publication
Researcher Affiliations
- Department of Animal Science, University of Florida, Gainesville 32611.
MeSH Terms
- Acid Phosphatase / metabolism
- Animals
- Estradiol / pharmacology
- Female
- Glycoproteins
- Horses / metabolism
- Isoenzymes
- Luteinizing Hormone / blood
- Metalloproteins / metabolism
- Progesterone / blood
- Progesterone / pharmacology
- Proteins / metabolism
- Serpins
- Tartrate-Resistant Acid Phosphatase
- Uterus / drug effects
- Uterus / enzymology
- Uterus / metabolism
Citations
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