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Home / Equine Research Bank / Can Vet J / [Comparison of the effects of xylazine and romifidine admini...
The Canadian veterinary journal = La revue veterinaire canadienne2012; 52(9); 987-993;

[Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses].

Abstract: Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses. The present study was designed to compare recoveries from anesthesia following the use of romifidine or xylazine in horses. In a prospective blind randomized clinical trial, 28 horses, undergoing elective arthroscopy, were randomly allocated into 2 groups. The intravenous anesthesia protocol used in the xylazine group was: butorphanol [0.02 mg/kg body weight (BW)] and xylazine (0.5 to 0.7 mg/kg BW) for premedication, diazepam (0.1 mg/kg BW) and ketamine (2.2 mg/kg BW) for induction, isoflurane in oxygen for maintenance and xylazine (0.1 mg/kg BW) in recovery. The xylazine was replaced with romifidine 0.05 to 0.08 mg/kg BW (premedication) and 0.01 mg/kg BW (recovery) in the romifidine group. The quality of recovery was evaluated with a modified scoring system and the duration recorded. Wilcoxon Ranked Sum test (P < 0.05) was used for statistical analysis. The recovery quality scores and the durations of recovery were not statistically different between the 2 groups. In this study, romifidine and xylazine were equal in their effects on recovery qualities.(Translated by the authors). Cette étude prospective compare les effets de la xylazine et de la romifidine sur la qualité du réveil de chevaux anesthésiés. Vingt-huit chevaux sains présentés pour des arthroscopies étaient aléatoirement distribués entre 2 groupes. Le protocole anesthésique intraveineux du groupe xylazine comprenait : butorphanol (0,02 mg/kg) et xylazine (0,5–0,7 mg/kg) en prémédication, diazépam (0,1 mg/kg), kétamine (2,2 mg/kg) et isoflurane comme agents anesthésiques, et xylazine (0,1 mg/kg) comme sédatif au réveil. La xylazine était remplacée par la romifidine 0,05–0,08 mg/kg (prémédication) et 0,01 mg/kg (réveil) dans le groupe romifidine. La qualité du réveil était évaluée à l’aveugle au moyen d’une grille d’évaluation. Le test de la somme des rangs de Wilcoxon ( < 0,05) a été utilisé pour l’analyse statistique. Les notes de la qualité du réveil n’étaient pas statiquement différentes entre les deux groupes. Dans cette étude, la romifidine et la xylazine influençaient de façon similaire la qualité du réveil.
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Publication Date: 2012-03-02 PubMed ID: 22379199PubMed Central: PMC3157074
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  • Comparative Study
  • English Abstract
  • Journal Article
  • Randomized Controlled Trial

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study compares the impact of two drugs, romifidine and xylazine, on the quality of recovery from anesthesia in horses undergoing elective arthroscopy. The researchers found no statistical difference in recovery quality scores or durations of recovery between the two groups of horses, concluding that romifidine and xylazine have similar effects on recovery qualities in horses.

Introduction and Methodology

  • The research aims to compare the effects of two anesthetic drugs, romifidine and xylazine, on the recovery of horses post-anesthesia.
  • In a blind randomized clinical trial, a total of 28 horses, set for elective arthroscopy, got randomly divided into 2 groups.
  • In the xylazine group, horse anesthesia followed a specific protocol: butorphanol and xylazine for premedication, diazepam and ketamine for inducing anesthesia, isoflurane in oxygen for maintenance, and xylazine for recovery.
  • The same anesthesia protocol was maintained for the romifidine group, except the researchers replaced xylazine with romifidine.

Recovery Evaluation

  • A modified scoring system was used to analyze the quality of recovery in horses, and the duration of recovery was recorded.
  • Statistical analysis of the collected data was performed using the Wilcoxon Ranked Sum test.

Results and Conclusion

  • Upon analysis, there was no statistical difference in recovery quality scores or durations of recovery between horses in the xylazine and romifidine groups.
  • The study concluded that the effects of romifidine and xylazine on horses’ recovery from anesthesia are similar. These suggest that either of the two drugs can be effectively used in anesthesia protocols during horse surgeries without significant differences in post-operative recovery time or quality.

Cite This Article

APA
Bauquier SH, Kona-Boun JJ. (2012). [Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses]. Can Vet J, 52(9), 987-993.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: fre
Volume: 52
Issue: 9
Pages: 987-993

Researcher Affiliations

Bauquier, Sébastien H
  • Service d'anesthésiologie, Université de Montréal, St. Hyacinthe (Québec). bauquier@unimelb.edu.au
Kona-Boun, Jean-Jacques

    MeSH Terms

    • Anesthesia Recovery Period
    • Anesthesia, Intravenous / veterinary
    • Anesthetics, Combined / administration & dosage
    • Animals
    • Arthroscopy / veterinary
    • Blood Gas Analysis / veterinary
    • Blood Pressure / drug effects
    • Blood Pressure / physiology
    • Diazepam / administration & dosage
    • Double-Blind Method
    • Female
    • Horses / physiology
    • Horses / surgery
    • Imidazoles / administration & dosage
    • Ketamine / administration & dosage
    • Male
    • Perioperative Care / veterinary
    • Prospective Studies
    • Time Factors
    • Xylazine / administration & dosage

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    Citations

    This article has been cited 2 times.
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    2. Aarnes TK, Bednarski RM, Bertone AL, Hubbell JA, Lerche P. Recovery from desflurane anesthesia in horses with and without post-anesthetic xylazine. Can J Vet Res 2014 Apr;78(2):103-9.
      pubmed: 24688171
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