FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
The Canadian veterinary journal = La revue veterinaire canadienne2012; 52(9); 987-993;

[Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses].

Abstract: Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses. The present study was designed to compare recoveries from anesthesia following the use of romifidine or xylazine in horses. In a prospective blind randomized clinical trial, 28 horses, undergoing elective arthroscopy, were randomly allocated into 2 groups. The intravenous anesthesia protocol used in the xylazine group was: butorphanol [0.02 mg/kg body weight (BW)] and xylazine (0.5 to 0.7 mg/kg BW) for premedication, diazepam (0.1 mg/kg BW) and ketamine (2.2 mg/kg BW) for induction, isoflurane in oxygen for maintenance and xylazine (0.1 mg/kg BW) in recovery. The xylazine was replaced with romifidine 0.05 to 0.08 mg/kg BW (premedication) and 0.01 mg/kg BW (recovery) in the romifidine group. The quality of recovery was evaluated with a modified scoring system and the duration recorded. Wilcoxon Ranked Sum test (P < 0.05) was used for statistical analysis. The recovery quality scores and the durations of recovery were not statistically different between the 2 groups. In this study, romifidine and xylazine were equal in their effects on recovery qualities.(Translated by the authors). Cette étude prospective compare les effets de la xylazine et de la romifidine sur la qualité du réveil de chevaux anesthésiés. Vingt-huit chevaux sains présentés pour des arthroscopies étaient aléatoirement distribués entre 2 groupes. Le protocole anesthésique intraveineux du groupe xylazine comprenait : butorphanol (0,02 mg/kg) et xylazine (0,5–0,7 mg/kg) en prémédication, diazépam (0,1 mg/kg), kétamine (2,2 mg/kg) et isoflurane comme agents anesthésiques, et xylazine (0,1 mg/kg) comme sédatif au réveil. La xylazine était remplacée par la romifidine 0,05–0,08 mg/kg (prémédication) et 0,01 mg/kg (réveil) dans le groupe romifidine. La qualité du réveil était évaluée à l’aveugle au moyen d’une grille d’évaluation. Le test de la somme des rangs de Wilcoxon ( < 0,05) a été utilisé pour l’analyse statistique. Les notes de la qualité du réveil n’étaient pas statiquement différentes entre les deux groupes. Dans cette étude, la romifidine et la xylazine influençaient de façon similaire la qualité du réveil.
Get Full Text
Publication Date: 2012-03-02 PubMed ID: 22379199PubMed Central: PMC3157074
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Comparative Study
  • English Abstract
  • Journal Article
  • Randomized Controlled Trial

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study compares the impact of two drugs, romifidine and xylazine, on the quality of recovery from anesthesia in horses undergoing elective arthroscopy. The researchers found no statistical difference in recovery quality scores or durations of recovery between the two groups of horses, concluding that romifidine and xylazine have similar effects on recovery qualities in horses.

Introduction and Methodology

  • The research aims to compare the effects of two anesthetic drugs, romifidine and xylazine, on the recovery of horses post-anesthesia.
  • In a blind randomized clinical trial, a total of 28 horses, set for elective arthroscopy, got randomly divided into 2 groups.
  • In the xylazine group, horse anesthesia followed a specific protocol: butorphanol and xylazine for premedication, diazepam and ketamine for inducing anesthesia, isoflurane in oxygen for maintenance, and xylazine for recovery.
  • The same anesthesia protocol was maintained for the romifidine group, except the researchers replaced xylazine with romifidine.

Recovery Evaluation

  • A modified scoring system was used to analyze the quality of recovery in horses, and the duration of recovery was recorded.
  • Statistical analysis of the collected data was performed using the Wilcoxon Ranked Sum test.

Results and Conclusion

  • Upon analysis, there was no statistical difference in recovery quality scores or durations of recovery between horses in the xylazine and romifidine groups.
  • The study concluded that the effects of romifidine and xylazine on horses’ recovery from anesthesia are similar. These suggest that either of the two drugs can be effectively used in anesthesia protocols during horse surgeries without significant differences in post-operative recovery time or quality.

Cite This Article

APA
Bauquier SH, Kona-Boun JJ. (2012). [Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses]. Can Vet J, 52(9), 987-993.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: fre
Volume: 52
Issue: 9
Pages: 987-993

Researcher Affiliations

Bauquier, Sébastien H
  • Service d'anesthésiologie, Université de Montréal, St. Hyacinthe (Québec). bauquier@unimelb.edu.au
Kona-Boun, Jean-Jacques

    MeSH Terms

    • Anesthesia Recovery Period
    • Anesthesia, Intravenous / veterinary
    • Anesthetics, Combined / administration & dosage
    • Animals
    • Arthroscopy / veterinary
    • Blood Gas Analysis / veterinary
    • Blood Pressure / drug effects
    • Blood Pressure / physiology
    • Diazepam / administration & dosage
    • Double-Blind Method
    • Female
    • Horses / physiology
    • Horses / surgery
    • Imidazoles / administration & dosage
    • Ketamine / administration & dosage
    • Male
    • Perioperative Care / veterinary
    • Prospective Studies
    • Time Factors
    • Xylazine / administration & dosage

    References

    This article includes 23 references
    1. Johnston GM, Taylor PM, Holmes MA, Wood JL. Confidential enquiry of perioperative equine fatalities (CEPEF-1): preliminary results.. Equine Vet J 1995 May;27(3):193-200.
      pubmed: 7556046doi: 10.1111/j.2042-3306.1995.tb03062.xgoogle scholar: lookup
    2. Johnston GM, Eastment JK, Wood J, Taylor PM. The confidential enquiry into perioperative equine fatalities (CEPEF): mortality results of Phases 1 and 2.. Vet Anaesth Analg 2002 Oct;29(4):159-170.
      pubmed: 28404360doi: 10.1046/j.1467-2995.2002.00106.xgoogle scholar: lookup
    3. Bidwell LA, Bramlage LR, Rood WA. Equine perioperative fatalities associated with general anaesthesia at a private practice--a retrospective case series.. Vet Anaesth Analg 2007 Jan;34(1):23-30.
      pubmed: 17238959doi: 10.1111/j.1467-2995.2005.00283.xgoogle scholar: lookup
    4. CLARKE KW, HALL LW. A survey of anaesthesia in small animal practice: AVA/BSAVA report. J Vet Anaes 1990;17:4–16.
    5. Brodbelt D. Perioperative mortality in small animal anaesthesia.. Vet J 2009 Nov;182(2):152-61.
      pubmed: 18658000doi: 10.1016/j.tvjl.2008.06.011google scholar: lookup
    6. Warden JC, Borton CL, Horan BF. Mortality associated with anaesthesia in New South Wales, 1984-1990.. Med J Aust 1994 Nov 21;161(10):585-93.
      pubmed: 7968726doi: 10.5694/j.1326-5377.1994.tb127636.xgoogle scholar: lookup
    7. Irita K, Kawashima Y, Iwao Y, Seo N, Tsuzaki K, Morita K, Obara H. [Annual mortality and morbidity in operating rooms during 2002 and summary of morbidity and mortality between 1999 and 2002 in Japan: a brief review].. Masui 2004 Mar;53(3):320-35.
      pubmed: 15071889
    8. Clarke KW, Hall LW. "Xylazine"--a new sedative for horses and cattle.. Vet Rec 1969 Nov 8;85(19):512-7.
      pubmed: 5349241doi: 10.1136/vr.85.19.512google scholar: lookup
    9. Santos M, Fuente M, Garcia-Iturralde R, Herran R, Lopez-Sanroman J, Tendillo FJ. Effects of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses.. Equine Vet J 2003 Mar;35(2):170-5.
      pubmed: 12638794doi: 10.2746/042516403776114117google scholar: lookup
    10. TRONICKE R, VOCKE G. Contributions to the use of the preparation Rompun as a sedative and for anaesthetic premedication in the horse. Veterinary Medical Reviews 1970;6:247–54.
    11. Clarke KW, Paton BS. Combined use of detomidine with opiates in the horse.. Equine Vet J 1988 Sep;20(5):331-4.
      pubmed: 3181117doi: 10.1111/j.2042-3306.1988.tb01540.xgoogle scholar: lookup
    12. England GC, Clarke KW, Goossens L. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse.. J Vet Pharmacol Ther 1992 Jun;15(2):194-201.
      pubmed: 1359161doi: 10.1111/j.1365-2885.1992.tb01007.xgoogle scholar: lookup
    13. Hamm D, Turchi P, Jöchle W. Sedative and analgesic effects of detomidine and romifidine in horses.. Vet Rec 1995 Apr 1;136(13):324-7.
      pubmed: 7604508doi: 10.1136/vr.136.13.324google scholar: lookup
    14. Donaldson LL, Dunlop GS, Holland MS, Burton BA. The recovery of horses from inhalant anesthesia: a comparison of halothane and isoflurane.. Vet Surg 2000 Jan-Feb;29(1):92-101.
      pubmed: 10653499doi: 10.1111/j.1532-950x.2000.00092.xgoogle scholar: lookup
    15. Matthews NS, Hartsfield SM, Mercer D, Beleau MH, MacKenthun A. Recovery from sevoflurane anesthesia in horses: comparison to isoflurane and effect of postmedication with xylazine.. Vet Surg 1998 Sep-Oct;27(5):480-5.
      pubmed: 9749520doi: 10.1111/j.1532-950x.1998.tb00160.xgoogle scholar: lookup
    16. Whitehair KJ, Steffey EP, Willits NH, Woliner MJ. Recovery of horses from inhalation anesthesia.. Am J Vet Res 1993 Oct;54(10):1693-702.
      pubmed: 8250395
    17. England GC, Clarke KW. Alpha 2 adrenoceptor agonists in the horse--a review.. Br Vet J 1996 Nov;152(6):641-57.
      pubmed: 8979422doi: 10.1016/s0007-1935(96)80118-7google scholar: lookup
    18. Valverde A, Gunkelt C, Doherty TJ, Giguère S, Pollak AS. Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses.. Equine Vet J 2005 Nov;37(6):559-64.
      pubmed: 16295936doi: 10.2746/042516405775314772google scholar: lookup
    19. Bienert A, Bartmann CP, von Oppen T, Poppe C, Schiemann V, Deegen E. [Standing behavior in horses after inhalation anesthesia with isoflurane (Isoflo) and postanesthetic sedation with romifidine (Sedivet) or xylazine (Rompun)].. Dtsch Tierarztl Wochenschr 2003 Jun;110(6):244-8.
      pubmed: 12866257
    20. WOJTASIAK_WYPART M, SOMA LR, RUDY JA, UBOH CE, BOSTON RC, DRIESSEN B. Pharmacokinetics and pharmaco-dynamics of romifidine hydrochloride in the horse. Vet Anaesth Analg Abstracts of the American College of Veterinary Anesthesiologists’ (ACVA) Annual Meeting; Phoenix, AZ. September 18–19, 2008; 2009. pp. 1–19.
      pubmed: 0
    21. Kerr CL, McDonell WN, Young SS. A comparison of romifidine and xylazine when used with diazepam/ketamine for short duration anesthesia in the horse.. Can Vet J 1996 Oct;37(10):601-9.
      pmc: PMC1576482pubmed: 8896874
    22. Auer JA, Garner HE, Amend JF, Hutcheson DP, Salem CA. Recovery from anaesthesia in ponies: a comparative study of the effects of isoflurane, enflurane, methoxyflurane and halothane.. Equine Vet J 1978 Jan;10(1):18-23.
      pubmed: 631101doi: 10.1111/j.2042-3306.1978.tb02207.xgoogle scholar: lookup
    23. Voulgaris DA, Hofmeister EH. Multivariate analysis of factors associated with post-anesthetic times to standing in isoflurane-anesthetized horses: 381 cases.. Vet Anaesth Analg 2009 Sep;36(5):414-20.
      pubmed: 19558369doi: 10.1111/j.1467-2995.2009.00472.xgoogle scholar: lookup

    Citations

    This article has been cited 2 times.
    1. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
      doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
    2. Aarnes TK, Bednarski RM, Bertone AL, Hubbell JA, Lerche P. Recovery from desflurane anesthesia in horses with and without post-anesthetic xylazine. Can J Vet Res 2014 Apr;78(2):103-9.
      pubmed: 24688171
    Subscribe to our newsletter
    Join 99,850 horse owners like you who receive our email updates on horse health and nutrition.