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Journal of veterinary pharmacology and therapeutics2005; 28(3); 299-304; doi: 10.1111/j.1365-2885.2005.00657.x

Comparison of topical lidocaine/prilocaine anesthetic cream and local infiltration of 2% lidocaine for episioplasty in mares.

Abstract: Local anesthesia and tissue inflammation associated with lidocaine infiltration and lidocaine/prilocaine topical anesthetic cream for episioplasty in mares were compared. Twenty-two mares were randomly assigned to lidocaine or lidocaine/prilocaine topical anesthetic cream treatment groups. Perineum and vulva were cleaned, 8-12 g (approximately 1 g/cm per side of vulva) of topical anesthetic cream was applied, and the area was covered by plastic wrap 30 min prior to beginning procedure. Alternately, lidocaine was injected (1 mL) every centimeter just prior to the procedure. Episioplasty was conducted using standard methods, but employing simple interrupted sutures. Horses were not sedated and use of a twitch was recorded. Four millimeter punch biopsies were harvested 1, 3, and 10 days following episioplasty and scored for degree of inflammation by a blinded pathologist. Clinical inflammation scores were assigned when biopsies were obtained. Seven of 11 horses receiving lidocaine infiltration required twitching, but none of the horses that received the anesthetic cream required twitching. Six of 11 and seven of 11 of the lidocaine and anesthetic cream groups, respectively, required twitching for episioplasty. Except for the clinical scores on day 3, no statistical differences for clinical and histopathologic scores between samples from the two treatment groups for a given day were identified. Use of lidocaine/prilocaine topical anesthetic cream was as effective as lidocaine infiltration in providing local anesthesia when performing episioplasty in mares. Its use decreased the need for twitching horses as well as the risk of deformation of the labia caused by lidocaine infiltration.
Publication Date: 2005-06-15 PubMed ID: 15953204DOI: 10.1111/j.1365-2885.2005.00657.xGoogle Scholar: Lookup
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  • Clinical Trial
  • Comparative Study
  • Journal Article
  • Randomized Controlled Trial

Summary

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The research study investigates the efficacy of two local anesthesia methods – lidocaine infiltration and lidocaine/prilocaine topical anesthetic cream – for episioplasty (vulval surgery) in mares. The results show both methods are quite efficient, but using the anesthetic cream lessens the need for twitching horses and the risk of labia deformation.

Objective

The main aim of the research is to compare two local anesthesia methods: lidocaine/prilocaine topical anesthetic cream and lidocaine infiltration, used for episioplasty in mares. The research intends to determine which method is more efficient and causes less tissue inflammation.

Methodology

  • The study involved 22 mares which were randomly divided into two groups to receive either lidocaine or lidocaine/prilocaine topical anesthetic cream treatment.
  • Prior to the procedure, perineum and vulva were cleaned, and a generous amount of topical anesthetic cream was applied, then covered with a plastic wrap for 30 minutes.
  • Alternatively, lidocaine was injected at regular intervals just prior to the procedure. Episioplasty was carried out using standard methods, with a consistent application of simple interrupted sutures.
  • No sedation was used during the procedure, and any use of a twitch was recorded. Biopsies were taken 1, 3, and 10 days after the procedure and assessed for the degree of inflammation by a blinded pathologist.

Findings

  • The results indicated that seven of the eleven horses that received lidocaine infiltration needed twitching. In contrast, none of the horses that received the anesthetic cream needed twitching.
  • A comparable number of horses in both the lidocaine and anesthetic cream groups needed twitching for the episioplasty procedure.
  • Aside from clinical scores on the third day, there were no significant statistical differences between the inflammation scores from the lidocaine and anesthetic cream groups on any given day.

Conclusion

Based on the analysis, it was concluded that lidocaine/prilocaine topical anesthetic cream was as effective as lidocaine infiltration for episioplasty in mares. Additionally, the use of the cream was shown to decrease the necessity of twitching horses and the risk of labia deformation caused by lidocaine infiltration.

Cite This Article

APA
Erkert RS, Macallister CG, Campbell G, Payton ME, Shawley R, Clarke CR. (2005). Comparison of topical lidocaine/prilocaine anesthetic cream and local infiltration of 2% lidocaine for episioplasty in mares. J Vet Pharmacol Ther, 28(3), 299-304. https://doi.org/10.1111/j.1365-2885.2005.00657.x

Publication

ISSN: 0140-7783
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 28
Issue: 3
Pages: 299-304

Researcher Affiliations

Erkert, R S
  • Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA. erkert@okstate.edu
Macallister, C G
    Campbell, G
      Payton, M E
        Shawley, R
          Clarke, C R

            MeSH Terms

            • Administration, Cutaneous
            • Anesthesia, Local / veterinary
            • Anesthetics, Local / administration & dosage
            • Anesthetics, Local / pharmacokinetics
            • Anesthetics, Local / pharmacology
            • Animals
            • Episiotomy / veterinary
            • Female
            • Genitalia, Female / surgery
            • Horses / physiology
            • Horses / surgery
            • Lidocaine / administration & dosage
            • Lidocaine / pharmacokinetics
            • Lidocaine / pharmacology
            • Pain Measurement / drug effects
            • Pain, Postoperative / prevention & control
            • Prilocaine / administration & dosage
            • Prilocaine / pharmacokinetics
            • Prilocaine / pharmacology
            • Skin / metabolism
            • Treatment Outcome

            Citations

            This article has been cited 1 times.
            1. Torcivia C, McDonnell S. Efficacy of Lidocaine Topical Solution in Reducing Discomfort Reaction of Horses to Intramuscular Vaccination.. Animals (Basel) 2022 Jun 28;12(13).
              doi: 10.3390/ani12131659pubmed: 35804558google scholar: lookup