Complete genome sequence of Corynebacterium pseudotuberculosis strain 1/06-A, isolated from a horse in North America.
Abstract: Corynebacterium pseudotuberculosis causes disease in several animal species, although distinct biovars exist that appear to be restricted to specific hosts. In order to facilitate a better understanding of the differences between biovars, we report here the complete genome sequence of the equine pathogen Corynebacterium pseudotuberculosis strain 1/06-A.
Publication Date: 2012-07-31 PubMed ID: 22843601PubMed Central: PMC3416248DOI: 10.1128/JB.00922-12Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study presents the full genome sequence of the Corynebacterium pseudotuberculosis strain 1/06-A, an infectious bacterium originating from a horse in North America meant to enhance our understanding of the variances between biovars.
Background
- Corynebacterium pseudotuberculosis is a bacterium known to cause diseases in numerous animal species, with distinctive biovars that only infect specific hosts.
- The motivation behind this research was to enhance understanding of the differences between biovars, and the complexity of the relationship between specific strains and their host animals by examining the complete genome sequence of a specific strain, 1/06-A.
Research Method
- The team behind this study performed full genome sequencing on the strain of Corynebacterium pseudotuberculosis (1/06-A) that was isolated from a horse in North America.
- The process of genome sequencing involved determining the complete DNA sequence, including all the genes that make up this particular bacterial strain.
Findings and Significance
- The results offered a complete genome sequence of Corynebacterium pseudotuberculosis strain 1/06-A.
- The significance of achieving a complete genome sequence is that it provides a thorough genetic map of the bacterium, this information can be used to better understand its biological functions, capabilities and its specific interactions with the equine host.
- Furthermore, detailing the diversity in genome sequences between different strains can promote an improved understanding of how specific strains are restricted to their host animals, and why some strains are more virulent than others. This will ultimately contribute to developing more effective diagnostic tools and treatments.
Cite This Article
APA
Pethick FE, Lainson AF, Yaga R, Flockhart A, Smith DG, Donachie W, Cerdeira LT, Silva A, Bol E, Lopes TS, Barbosa MS, Pinto AC, Dos Santos AR, Soares SC, Almeida SS, Guimaraes LC, Aburjaile FF, Abreu VA, Ribeiro D, Fiaux KK, Diniz CA, Barbosa EG, Pereira UP, Hassan SS, Ali A, Bakhtiar SM, Dorella FA, Carneiro AR, Ramos RT, Rocha FS, Schneider MP, Miyoshi A, Azevedo V, Fontaine MC.
(2012).
Complete genome sequence of Corynebacterium pseudotuberculosis strain 1/06-A, isolated from a horse in North America.
J Bacteriol, 194(16), 4476.
https://doi.org/10.1128/JB.00922-12 Publication
Researcher Affiliations
- Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian, United Kingdom.
MeSH Terms
- Animals
- Corynebacterium Infections / veterinary
- Corynebacterium pseudotuberculosis / genetics
- Corynebacterium pseudotuberculosis / isolation & purification
- DNA, Bacterial / chemistry
- DNA, Bacterial / genetics
- Genome, Bacterial
- Horse Diseases / microbiology
- Horses
- Molecular Sequence Data
- North America
- Sequence Analysis, DNA
References
This article includes 8 references
- Baird GJ, Fontaine MC. Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis.. J Comp Pathol 2007 Nov;137(4):179-210.
- Connor KM, Fontaine MC, Rudge K, Baird GJ, Donachie W. Molecular genotyping of multinational ovine and caprine Corynebacterium pseudotuberculosis isolates using pulsed-field gel electrophoresis.. Vet Res 2007 Jul-Aug;38(4):613-23.
- Lagesen K, Hallin P, Rødland EA, Staerfeldt HH, Rognes T, Ussery DW. RNAmmer: consistent and rapid annotation of ribosomal RNA genes.. Nucleic Acids Res 2007;35(9):3100-8.
- Lowe TM, Eddy SR. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.. Nucleic Acids Res 1997 Mar 1;25(5):955-64.
- Miller JR, Delcher AL, Koren S, Venter E, Walenz BP, Brownley A, Johnson J, Li K, Mobarry C, Sutton G. Aggressive assembly of pyrosequencing reads with mates.. Bioinformatics 2008 Dec 15;24(24):2818-24.
- Rutherford K, Parkhill J, Crook J, Horsnell T, Rice P, Rajandream MA, Barrell B. Artemis: sequence visualization and annotation.. Bioinformatics 2000 Oct;16(10):944-5.
- Zdobnov EM, Apweiler R. InterProScan--an integration platform for the signature-recognition methods in InterPro.. Bioinformatics 2001 Sep;17(9):847-8.
- Zerbino DR, Birney E. Velvet: algorithms for de novo short read assembly using de Bruijn graphs.. Genome Res 2008 May;18(5):821-9.
Citations
This article has been cited 5 times.- Almeida S, Sousa C, Abreu V, Diniz C, Dorneles EM, Lage AP, Barh D, Azevedo V. Exploration of Nitrate Reductase Metabolic Pathway in Corynebacterium pseudotuberculosis.. Int J Genomics 2017;2017:9481756.
- Heggelund L, Gaustad P, Håvelsrud OE, Blom J, Borgen L, Sundset A, Sørum H, Frøland SS. Corynebacterium pseudotuberculosis Pneumonia in a Veterinary Student Infected During Laboratory Work.. Open Forum Infect Dis 2015 Apr;2(2):ofv053.
- Bomholt C, Glaub A, Gravermann K, Albersmeier A, Brinkrolf K, Rückert C, Tauch A. Whole-Genome Sequence of the Clinical Strain Corynebacterium argentoratense DSM 44202, Isolated from a Human Throat Specimen.. Genome Announc 2013 Oct 3;1(5).
- Burkovski A. Cell envelope of corynebacteria: structure and influence on pathogenicity.. ISRN Microbiol 2013;2013:935736.
- Soares SC, Silva A, Trost E, Blom J, Ramos R, Carneiro A, Ali A, Santos AR, Pinto AC, Diniz C, Barbosa EG, Dorella FA, Aburjaile F, Rocha FS, Nascimento KK, Guimarães LC, Almeida S, Hassan SS, Bakhtiar SM, Pereira UP, Abreu VA, Schneider MP, Miyoshi A, Tauch A, Azevedo V. The pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strains.. PLoS One 2013;8(1):e53818.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
