Complete Genome Sequence of Corynebacterium pseudotuberculosis Strain E19, Isolated from a Horse in Chile.
Abstract: Corynebacterium pseudotuberculosis is related to several diseases infecting horses and small ruminants, causing economic losses to agribusiness. Here, we present the genome sequence of C. pseudotuberculosis strain E19. The genome includes one circular chromosome 2,367,956 bp (52.1% G+C content), with 2,112 genes predicted, 12 rRNAs, and 48 tRNAs.
Copyright © 2015 Cavalcante et al.
Publication Date: 2015-11-25 PubMed ID: 26607893PubMed Central: PMC4661312DOI: 10.1128/genomeA.01385-15Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article represents the complete genomic sequence of the Corynebacterium pseudotuberculosis bacterium strain E19, a bacterium responsible for various diseases in horses and other small ruminants causing economic damage in the agricultural sector.
Understanding Corynebacterium pseudotuberculosis
- Corynebacterium pseudotuberculosis (C. pseudotuberculosis) is a bacterium known to cause a variety of health issues in animals, particularly horses and other small ruminants. The bacterium infects these animals, often leading to severe infections that can cause economic losses in agriculture.
Objective of the Research
- The researchers aimed to explore the complete genome of C. pseudotuberculosis, a critical step in understanding its biology and pathogenesis. This understanding could potentially contribute to developing strategies for infection control and management, and possibly even finding a cure.
Genome Sequence of C. pseudotuberculosis E19 Strain
- The genome of C. pseudotuberculosis E19 strain includes a single, circular chromosome which is 2,367,956 base pairs long. The G+C content, a measure of the guanine (G) and cytosine (C) bases in the DNA, is 52.1%.
- The organism’s genome is predicted to have 2,112 genes.
Ribosomal and Transfer RNA
- The genome also contains 12 ribosomal RNAs (rRNAs) and 48 transfer RNAs (tRNAs).
- rRNAs are part of the protein-making machinery in cells, and tRNAs deliver the necessary amino acids for protein synthesis. These rRNAs and tRNAs add further intricacy to the genome of the bacterium.
Significance of the Study
- By sequencing and understanding the C. pseudotuberculosis E19 genome, this research can complement other studies that aim to gain insights into the bacterium’s biology, pathology, and evolution.
- Furthermore, the genomic details may help in developing effective treatments or preventive measures against diseases caused by this bacterium, thereby reducing associated economic losses in agriculture.
Cite This Article
APA
Cavalcante AL, Dias LM, Alves JT, Veras AA, Guimarães LC, Rocha FS, Gala-García A, Retamal P, Ramos RT, Azevedo V, Silva A, Carneiro AR.
(2015).
Complete Genome Sequence of Corynebacterium pseudotuberculosis Strain E19, Isolated from a Horse in Chile.
Genome Announc, 3(6), e01385-15.
https://doi.org/10.1128/genomeA.01385-15 Publication
Researcher Affiliations
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- Department of Animal Preventive Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago, Chile.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil.
- Federal University of Pará, Center of Genomic and Systems Biology, Laboratory of Genomics and Bioinformatics, Belém, Pará, Brazil adrianarc@ufpa.br.
References
This article includes 12 references
- Lehmann KB, Neumann R. Lehmann’s Medizin, Handatlanten. X. Atlas und Grundriss der Bakteriologie und Lehrbuch der speciellen bacteriologischen Diagnostik. 1907, 4th ed. J.F. Lehmann, Munich, Germany.
- Dorella FA, Pacheco LG, Oliveira SC, Miyoshi A, Azevedo V. Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence.. Vet Res 2006 Mar-Apr;37(2):201-18.
- Baird GJ, Fontaine MC. Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis.. J Comp Pathol 2007 Nov;137(4):179-210.
- Dorella FA, Pacheco LG, Coelho KS, Rocha C, Lobo FP, Franco GR, Meyer R, Cardoso PG, Miyoshi A, Azevedo V. Sequenciamento do genoma de Corynebacterium pseudotuberculosis pela rede genoma de minas gerais: impactos esperados na ovino e capricultura nacional. Biotecnologia e saúde animal 2007, p 111–150, 1st ed. Editora Universidade Federal de Viçosa, Viçosa, Brazil.
- Warren KLH, Sponseller BT, Wong DM, Kinyon JM. Isolation of Corynebacterium pseudotuberculosis biovar equi from a horse in central Iowa. Case Rep Vet Med 2014:436287.
- Spier SJ. Corynebacterium pseudotuberculosis infection in horses: an emerging disease associated with climate change?. Equine Vet Educ 20:37–39.
- Nurk S, Bankevich A, Antipov D, Gurevich AA, Korobeynikov A, Lapidus A, Prjibelski AD, Pyshkin A, Sirotkin A, Sirotkin Y, Stepanauskas R, Clingenpeel SR, Woyke T, McLean JS, Lasken R, Tesler G, Alekseyev MA, Pevzner PA. Assembling single-cell genomes and mini-metagenomes from chimeric MDA products.. J Comput Biol 2013 Oct;20(10):714-37.
- Darling AE, Mau B, Perna NT. progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.. PLoS One 2010 Jun 25;5(6):e11147.
- Rutherford K, Parkhill J, Crook J, Horsnell T, Rice P, Rajandream MA, Barrell B. Artemis: sequence visualization and annotation.. Bioinformatics 2000 Oct;16(10):944-5.
- Overbeek R, Olson R, Pusch GD, Olsen GJ, Davis JJ, Disz T, Edwards RA, Gerdes S, Parrello B, Shukla M, Vonstein V, Wattam AR, Xia F, Stevens R. The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST).. Nucleic Acids Res 2014 Jan;42(Database issue):D206-14.
- Lagesen K, Hallin P, Rødland EA, Staerfeldt HH, Rognes T, Ussery DW. RNAmmer: consistent and rapid annotation of ribosomal RNA genes.. Nucleic Acids Res 2007;35(9):3100-8.
- Lowe TM, Eddy SR. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.. Nucleic Acids Res 1997 Mar 1;25(5):955-64.
Citations
This article has been cited 2 times.- Meng W, Chen S, Huang L, Yang J, Zhang W, Zhong Z, Zhou Z, Liu H, Fu H, He T, Peng G. Isolation, characterization, and pathogenicity assessment of Corynebacterium pseudotuberculosis biovar equi strains from alpacas (Vicugna pacos) in China. Front Microbiol 2023;14:1206187.
- Baraúna RA, Ramos RT, Veras AA, Pinheiro KC, Benevides LJ, Viana MV, Guimarães LC, Edman JM, Spier SJ, Azevedo V, Silva A. Assessing the Genotypic Differences between Strains of Corynebacterium pseudotuberculosis biovar equi through Comparative Genomics. PLoS One 2017;12(1):e0170676.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
