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Home / Equine Research Bank / J Virol / Complete genome sequence of equine herpesvirus type 9.
Journal of virology2012; 86(24); 13822; doi: 10.1128/JVI.02607-12

Complete genome sequence of equine herpesvirus type 9.

Abstract: Equine herpesvirus type 9 (EHV-9), which we isolated from a case of epizootic encephalitis in a herd of Thomson's gazelles (Gazella thomsoni) in 1993, has been known to cause fatal encephalitis in Thomson's gazelle, giraffe, and polar bear in natural infections. Our previous report indicated that EHV-9 was similar to the equine pathogen equine herpesvirus type 1 (EHV-1), which mainly causes abortion, respiratory infection, and equine herpesvirus myeloencephalopathy. We determined the genome sequence of EHV-9. The genome has a length of 148,371 bp and all 80 of the open reading frames (ORFs) found in the genome of EHV-1. The nucleotide sequences of the ORFs in EHV-9 were 86 to 95% identical to those in EHV-1. The whole genome sequence should help to reveal the neuropathogenicity of EHV-9.
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Publication Date: 2012-11-21 PubMed ID: 23166237PubMed Central: PMC3503125DOI: 10.1128/JVI.02607-12Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The researchers successfully mapped the complete genome sequence of Equine herpesvirus type 9 (EHV-9), a pathogen found in multiple species like gazelles, giraffes, and polar bears. The sequencing data revealed that EHV-9 has high genetic similarity to EHV-1, which commonly causes abortions and respiratory infections in horses.

Unpacking the Abstract

  • Equine herpesvirus type 9 (EHV-9) is the focus of this research, a virus first isolated from an outbreak (epizootic) of encephalitis in a herd of Thomson’s gazelles in 1993.
  • EHV-9 is known to cause fatal encephalitis, an inflammation of the brain, in animals such as Thomson’s gazelles, giraffes, and polar bears. However, it’s not yet clear from this abstract whether the virus affects other animal species or humans.
  • In previous research, EHV-9 was found to be similar to another virus known as equine herpesvirus type 1 (EHV-1). EHV-1 mainly affects horses, causing a range of symptoms including abortion, respiratory infections, and a neurological condition known as equine herpesvirus myeloencephalopathy.

Decoding the Genome Sequence

  • In this study, the researchers have determined the complete genome sequence of EHV-9, involving the mapping of its genetic information.
  • The length of the genome is 148,371 base pairs (bp), which is a measurement of the amount of genetic material in the virus. The virus’s genome has 80 open reading frames (ORFs), which means there are 80 distinct sections of the genome that could potentially be used to create proteins.
  • The researchers found that the sequences of these ORFs in EHV-9 were 86 to 95% identical to those found in EHV-1, indicating a high degree of similarity between the two viruses.

Implications for Understanding EHV-9

  • The sequencing of the whole EHV-9 genome is intended to help in understanding the virus’s neuropathogenicity, meaning its ability to cause disease in the nervous system. This is particularly relevant given the known tendency of the virus to cause in fatal encephalitis.
  • Knowing the complete genome sequence can also contribute to studies on its epidemiology, pathogenesis, immune response, vaccine development, and other fields.

Cite This Article

APA
Fukushi H, Yamaguchi T, Yamada S. (2012). Complete genome sequence of equine herpesvirus type 9. J Virol, 86(24), 13822. https://doi.org/10.1128/JVI.02607-12

Publication

Journal of virology
ISSN: 1098-5514
NlmUniqueID: 0113724
Country: United States
Language: English
Volume: 86
Issue: 24
Pages: 13822

Researcher Affiliations

Fukushi, Hideto
  • Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan. hfukushi@gifu-u.ac.jp
Yamaguchi, Tsuyoshi
    Yamada, Souichi

      MeSH Terms

      • Animals
      • Genome, Viral
      • Herpesviridae / genetics
      • Horses / genetics
      • Molecular Sequence Data
      • Open Reading Frames

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      Citations

      This article has been cited 8 times.
      1. Hu L, Wang T, Ren H, Liu W, Li Y, Wang C, Li L. Characterizing the Pathogenesis and Immune Response of Equine Herpesvirus 8 Infection in Lung of Mice.. Animals (Basel) 2022 Sep 20;12(19).
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      2. Câmara RJF, Bueno BL, Resende CF, Balasuriya UBR, Sakamoto SM, Reis JKPD. Viral Diseases that Affect Donkeys and Mules.. Animals (Basel) 2020 Nov 25;10(12).
        doi: 10.3390/ani10122203pubmed: 33255568google scholar: lookup
      3. Wimer CL, Schnabel CL, Perkins G, Babasyan S, Freer H, Stout AE, Rollins A, Osterrieder N, Goodman LB, Glaser A, Wagner B. The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses.. PLoS One 2018;13(11):e0206679.
        doi: 10.1371/journal.pone.0206679pubmed: 30440016google scholar: lookup
      4. Marenzoni ML, Stefanetti V, Danzetta ML, Timoney PJ. Gammaherpesvirus infections in equids: a review.. Vet Med (Auckl) 2015;6:91-101.
        doi: 10.2147/VMRR.S39473pubmed: 30155436google scholar: lookup
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        doi: 10.1177/1040638718767722pubmed: 29648506google scholar: lookup
      6. Abdelgawad A, Damiani A, Ho SY, Strauss G, Szentiks CA, East ML, Osterrieder N, Greenwood AD. Zebra Alphaherpesviruses (EHV-1 and EHV-9): Genetic Diversity, Latency and Co-Infections.. Viruses 2016 Sep 20;8(9).
        doi: 10.3390/v8090262pubmed: 27657113google scholar: lookup
      7. Sijmons S, Vissani A, Tordoya MS, Muylkens B, Thiry E, Maes P, Matthijnssens J, Barrandeguy M, Van Ranst M. Complete genome sequence of equid herpesvirus 3.. Genome Announc 2014 Oct 2;2(5).
        doi: 10.1128/genomeA.00797-14pubmed: 25278519google scholar: lookup
      8. Guo X, Izume S, Okada A, Ohya K, Kimura T, Fukushi H. Full genome sequences of zebra-borne equine herpesvirus type 1 isolated from zebra, onager and Thomson's gazelle.. J Vet Med Sci 2014 Sep;76(9):1309-12.
        doi: 10.1292/jvms.14-0183pubmed: 24920546google scholar: lookup
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