Complete genomic sequence of an equine herpesvirus type 8 Wh strain isolated from China.
Abstract: A new strain of equine herpesvirus type 8 (EHV-8), Wh, has been isolated from horses in China, and its complete genome has been sequenced and analyzed. The result indicates that the new strain has the same constitution and arrangement of open read frames as EHV-1 and EHV-9. This work is the first announced complete genome sequence of EHV-8.
Publication Date: 2012-04-12 PubMed ID: 22492929PubMed Central: PMC3347380DOI: 10.1128/JVI.00445-12Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research details the identification and genomic sequencing of a new strain of equine herpesvirus type 8 (EHV-8), identified as Wh, found in horses in China. This is the first time a complete genome sequence of EHV-8 has been published.
Research Overview
The research is primarily focused on the identification and understanding of a new strain of the equine herpesvirus type 8 (EHV-8), called the Wh strain, found in horses in China. The study also includes the successful sequencing of the whole genome of this virus strain.
- The researchers have successfully identified and isolated a new strain of EHV-8, a virus affecting horses, which they have named Wh. This strain was found in China.
- The main objective of this research involves understanding this new viral strain through the sequencing and analysis of its entire genome.
- This is a significant development since this is the first time a full genome sequence of EHV-8 has been established and published.
Findings
The results of this genome sequencing pointed to interesting findings regarding the genetic make-up of the EHV-8 Wh strain.
- Upon analysis, it was found that the structure and open reading frame (a part of the genetic sequence which can potentially be translated to produce proteins) arrangement of the newly identified virus strain are similar to those of EHV-1 and EHV-9.
- These findings indicate that this new EHV-8 strain shares genetic characteristics with the previously studied EHV strains, potentially indicating a common origin or similar evolutionary pathways.
Significance
The identification and genome sequencing of this new EHV-8 strain has significant implications for equine health care.
- Understanding the genetic make-up of this strain helps in the development of targeted treatment strategies, including potential vaccines.
- These findings also contribute to the ongoing epidemiological research on equine herpesviruses, enriching the collective knowledge on the evolution and diversity of these viruses that can impact horses worldwide.
Cite This Article
APA
Liu C, Guo W, Lu G, Xiang W, Wang X.
(2012).
Complete genomic sequence of an equine herpesvirus type 8 Wh strain isolated from China.
J Virol, 86(9), 5407.
https://doi.org/10.1128/JVI.00445-12 Publication
Researcher Affiliations
- State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
MeSH Terms
- Alphaherpesvirinae / genetics
- Alphaherpesvirinae / isolation & purification
- Animals
- China
- Genome, Viral
- Horses
- Molecular Sequence Annotation
- Molecular Sequence Data
- Rabbits
References
This article includes 7 references
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Citations
This article has been cited 10 times.- Li L, Hu X, Li S, Li Y, Zhao S, Shen F, Wang C, Li Y, Wang T. Cobalt Protoporphyrin Blocks EqHV-8 Infection via IFN-α/β Production.. Animals (Basel) 2023 Aug 22;13(17).
- Wang T, Xi C, Yu Y, Liu W, Akhtar MF, Li Y, Wang C, Li L. Characteristics and epidemiological investigation of equid herpesvirus 8 in donkeys in Shandong, China.. Arch Virol 2023 Mar 4;168(3):99.
- Hu L, Wang T, Ren H, Liu W, Li Y, Wang C, Li L. Characterizing the Pathogenesis and Immune Response of Equine Herpesvirus 8 Infection in Lung of Mice.. Animals (Basel) 2022 Sep 20;12(19).
- Wang T, Hu L, Liu M, Wang T, Hu X, Li Y, Liu W, Li Y, Wang Y, Ren H, Zhang W, Wang C, Li L. The Emergence of Viral Encephalitis in Donkeys by Equid Herpesvirus 8 in China.. Front Microbiol 2022;13:840754.
- Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Roberts HC, Padalino B, Pasquali P, Spoolder H, Ståhl K, Calvo AV, Viltrop A, Winckler C, Carvelli A, Paillot R, Broglia A, Kohnle L, Baldinelli F, Van der Stede Y. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infection with Equine Herpesvirus-1.. EFSA J 2022 Jan;20(1):e07036.
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- Bryant NA, Wilkie GS, Russell CA, Compston L, Grafham D, Clissold L, McLay K, Medcalf L, Newton R, Davison AJ, Elton DM. Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks.. Transbound Emerg Dis 2018 Jun;65(3):817-832.
- Garvey M, Suárez NM, Kerr K, Hector R, Moloney-Quinn L, Arkins S, Davison AJ, Cullinane A. Equid herpesvirus 8: Complete genome sequence and association with abortion in mares.. PLoS One 2018;13(2):e0192301.
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