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Molecular biology reports2017; 44(2); 233-242; doi: 10.1007/s11033-017-4101-8

Complete mitochondrial genome sequences of Korean native horse from Jeju Island: uncovering the spatio-temporal dynamics.

Abstract: The Korean native horse (Jeju horse) is one of the most important animals in Korean historical, cultural, and economical viewpoints. In the early 1980s, the Jeju horse was close to extinction. The aim of this study is to explore the phylogenomics of Korean native horse focusing on spatio-temporal dynamics. We determined complete mitochondrial genome sequences for the first Korean native (n = 6) and additional Mongolian (n = 2) horses. Those sequences were analyzed together with 143 published ones using Bayesian coalescent approach as well as three different phylogenetic analysis methods, Bayesian inference, maximum likelihood, and neighbor-joining methods. The phylogenomic trees revealed that the Korean native horses had multiple origins and clustered together with some horses from four European and one Middle Eastern breeds. Our phylogenomic analyses also supported that there was no apparent association between breed or geographic location and the evolution of global horses. Time of the most recent common ancestor of the Korean native horse was approximately 13,200-63,200 years, which was much younger than 0.696 My of modern horses. Additionally, our results showed that all global horse lineages including Korean native horse existed prior to their domestication events occurred in about 6000-10,000 years ago. This is the first study on phylogenomics of the Korean native horse focusing on spatio-temporal dynamics. Our findings increase our understanding of the domestication history of the Korean native horses, and could provide useful information for horse conservation projects as well as for horse genomics, emergence, and the geographical distribution.
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Publication Date: 2017-04-21 PubMed ID: 28432484DOI: 10.1007/s11033-017-4101-8Google Scholar: Lookup
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Summary

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This research study focuses on the phylogenomics of the Korean native horse (Jeju horse), with an emphasis on spatio-temporal dynamics. The study entails acquiring full mitochondrial genome sequences from native Korean and Mongolian horses, and these sequences are investigated together with 143 other published sequences using different phylogenetic analysis techniques, to understand the relationships among breeds and geographic locations.

Research Methodology

  • The research involved collecting complete mitochondrial genome sequences of the Korean native horses (Jeju horse) and two Mongolian horses.
  • Those sequences were examined in conjunction with 143 other previously published sequences.
  • Three different phylogenetic analyses methods were used to study the data: Bayesian inference, maximum likelihood, and neighbor-joining methods.

Key Findings

  • The Korean native horses studied were found to have multiple origins.
  • The Korean horses grouped together with some horses from four European breeds and one Middle Eastern breed.
  • The study found no significant correlation between breed or geographical location and the evolution pathways of global horses.
  • The most recent common ancestor of the Korean native horse was approximated to be 13,200-63,200 years, which is younger than the 0.696 My of modern horses.
  • All global horse breeds, including the Korean native horse, were established prior to the domestication events that occurred approximately 6000-10,000 years ago.

Significance of the Research

  • This is the first study focusing on the phylogenomics (the study of physical and functional genome properties) of the Korean native horse in relation to spatio-temporal dynamics.
  • The findings offer a deeper understanding of the domestication history of the Korean native horses, contributing to global knowledge about horse evolution.
  • The research provides valuable information that could be used in horse conservation projects, and insights into the genomic evolution, the emergence of horse breeds, and their geographic distribution.

Cite This Article

APA
Yoon SH, Kim J, Shin D, Cho S, Kwak W, Lee HK, Park KD, Kim H. (2017). Complete mitochondrial genome sequences of Korean native horse from Jeju Island: uncovering the spatio-temporal dynamics. Mol Biol Rep, 44(2), 233-242. https://doi.org/10.1007/s11033-017-4101-8

Publication

Molecular biology reports
ISSN: 1573-4978
NlmUniqueID: 0403234
Country: Netherlands
Language: English
Volume: 44
Issue: 2
Pages: 233-242

Researcher Affiliations

Yoon, Sook Hee
  • Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
Kim, Jaemin
  • Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
Shin, Donghyun
  • Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
Cho, Seoae
  • C&K Genomics, Seoul National University Mt.4-2, Main Bldg. #514, SNU Research Park, NakSeoungDae, Gwanakgu, Seoul, 151-919, Republic of Korea.
Kwak, Woori
  • Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Republic of Korea.
Lee, Hak-Kyo
  • The Animal Genomics and Breeding Center, Chonbuk National University, Jeonju, 561-756, Republic of Korea.
Park, Kyoung-Do
  • Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Republic of Korea. doobalo@hknu.ac.kr.
Kim, Heebal
  • Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-742, Republic of Korea. heebal@snu.ac.kr.
  • C&K Genomics, Seoul National University Mt.4-2, Main Bldg. #514, SNU Research Park, NakSeoungDae, Gwanakgu, Seoul, 151-919, Republic of Korea. heebal@snu.ac.kr.

MeSH Terms

  • Animals
  • Bayes Theorem
  • Biological Evolution
  • Breeding
  • DNA, Mitochondrial / genetics
  • Genome, Mitochondrial / genetics
  • Horses / genetics
  • Korea
  • Mitochondria / genetics
  • Phylogeny
  • Phylogeography / methods
  • Sequence Analysis, DNA / methods

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Citations

This article has been cited 6 times.
  1. Saldaña CL, Justo S, Murga L, Vásquez HV, Maicelo JL, Arbizu CI, Bardales W. Mitochondrial genome assembly of the Peruvian Paso horse through PacBio long-read sequencing. Sci Rep 2025 Dec 21;16(1):85.
    doi: 10.1038/s41598-025-29107-xpubmed: 41423464google scholar: lookup
  2. Agbani A, Aminou O, Machmoum M, Germot A, Badaoui B, Petit D, Piro M. A Systematic Literature Review of Mitochondrial DNA Analysis for Horse Genetic Diversity. Animals (Basel) 2025 Mar 20;15(6).
    doi: 10.3390/ani15060885pubmed: 40150414google scholar: lookup
  3. Lee S, Lee EB, Park KW, Jeong H, Shin KY, Kweon YP, Seo JP. Computed tomographic features of the temporomandibular joint in 10 Jeju horses. J Vet Sci 2022 May;23(3):e44.
    doi: 10.4142/jvs.21318pubmed: 35466600google scholar: lookup
  4. Lee W, Mun S, Choi SY, Oh DY, Park YS, Han K. Comparative Analysis for Genetic Characterization in Korean Native Jeju Horse. Animals (Basel) 2021 Jun 28;11(7).
    doi: 10.3390/ani11071924pubmed: 34203473google scholar: lookup
  5. Lee HY, Kim JY, Kim KH, Jeong S, Cho Y, Kim N. Gene Expression Profile in Similar Tissues Using Transcriptome Sequencing Data of Whole-Body Horse Skeletal Muscle. Genes (Basel) 2020 Nov 17;11(11).
    doi: 10.3390/genes11111359pubmed: 33213000google scholar: lookup
  6. Srikanth K, Kim NY, Park W, Kim JM, Kim KD, Lee KT, Son JH, Chai HH, Choi JW, Jang GW, Kim H, Ryu YC, Nam JW, Park JE, Kim JM, Lim D. Comprehensive genome and transcriptome analyses reveal genetic relationship, selection signature, and transcriptome landscape of small-sized Korean native Jeju horse. Sci Rep 2019 Nov 13;9(1):16672.
    doi: 10.1038/s41598-019-53102-8pubmed: 31723199google scholar: lookup
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