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Home / Equine Research Bank / J Bone Joint Surg Am / Concentrated bone marrow aspirate improves full-thickness ca...
The Journal of bone and joint surgery. American volume2010; 92(10); 1927-1937; doi: 10.2106/JBJS.I.01284

Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model.

Abstract: The purpose of this study was to compare the outcomes of treatment with bone marrow aspirate concentrate, a simple, one-step, autogenous, and arthroscopically applicable method, with the outcomes of microfracture with regard to the repair of full-thickness cartilage defects in an equine model. Methods: Extensive (15-mm-diameter) full-thickness cartilage defects were created on the lateral trochlear ridge of the femur in twelve horses. Bone marrow was aspirated from the sternum and centrifuged to generate the bone marrow concentrate. The defects were treated with bone marrow concentrate and microfracture or with microfracture alone. Second-look arthroscopy was performed at three months, and the horses were killed at eight months. Repair was assessed with use of macroscopic and histological scoring systems as well as with quantitative magnetic resonance imaging. Results: No adverse reactions due to the microfracture or the bone marrow concentrate were observed. At eight months, macroscopic scores (mean and standard error of the mean, 9.4 + or - 1.2 compared with 4.4 + or - 1.2; p = 0.009) and histological scores (11.1 + or - 1.6 compared with 6.4 + or - 1.2; p = 0.02) indicated improvement in the repair tissue in the bone marrow concentrate group compared with that in the microfracture group. All scoring systems and magnetic resonance imaging data indicated that delivery of the bone marrow concentrate resulted in increased fill of the defects and improved integration of repair tissue into surrounding normal cartilage. In addition, there was greater type-II collagen content and improved orientation of the collagen as well as significantly more glycosaminoglycan in the bone marrow concentrate-treated defects than in the microfracture-treated defects. Conclusions: Delivery of bone marrow concentrate can result in healing of acute full-thickness cartilage defects that is superior to that after microfracture alone in an equine model. Conclusions: Delivery of bone marrow concentrate to cartilage defects has the clinical potential to improve cartilage healing, providing a simple, cost-effective, arthroscopically applicable, and clinically effective approach for cartilage repair.
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Publication Date: 2010-08-20 PubMed ID: 20720135DOI: 10.2106/JBJS.I.01284Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examines the effect of bone marrow aspirate concentrate on the repair of cartilage defects compared to traditional methods, specifically in horses. The research suggests that the use of bone marrow concentrate improves not only the speed and quality of repair, but also results in better integration of the repaired cartilage with the surrounding tissue than microfracture methods.

Study Design and Methodology

  • The study was aimed at comparing the effectiveness of bone marrow aspirate concentrate and microfracture in repairing full-thickness cartilage defects using an equine model.
  • Large, full-thickness defects (15mm in diameter) were created in the lateral trochlear ridge of the femur in twelve test subjects (horses).
  • Bone marrow was aspirated from the sternum of the equine subjects, which was then processed through centrifugation to create concentrated bone marrow extracts.
  • The defects were then treated using either the bone marrow concentrate or the microfracture technique (or both techniques in some cases).
  • A follow-up examination was conducted after three months using arthroscopy, and the animals were euthanized for further study at the eight-month mark.
  • The quality of the repair was assessed using both macroscopic and histological scoring systems as well as with the help of quantitative Magnetic Resonance Imaging (MRI).

Findings and Results

  • The study did not observe any adverse reactions associated with either the microfracture or bone marrow concentrate treatments.
  • At the end of the eight-month period, both the macroscopic score (mean ± standard error of the mean, 9.4 ± 1.2 vs. 4.4 ± 1.2; p = 0.009) and histological score (11.1 ± 1.6 vs.6.4 ± 1.2; p = 0.02) demonstrated marked improvement in the repair tissue in the group treated with bone marrow concentrate compared to the group treated using microfracture.
  • Further, the MRI data, as well as all scoring systems, indicated that the application of bone marrow concentrate resulted in better filling of the defects and improved integration of the repair tissue with the surrounding normal cartilage.
  • Additionally, the treatment with bone marrow concentrate led to higher levels of collagen type-II content within the defects, a superior orientation of collagen, as well as a significant increase in the amounts of glycosaminoglycan.

Conclusions

  • The results of the study suggested that bone marrow concentrate could be superior to microfracture for healing acute full-thickness cartilage defects.
  • The study concluded that the application of such a treatment method to cartilage defects has the potential to improve the viability and effectiveness of clinical cartilage healing. This approach is advantageous as it is simple, cost-effective, can be applied arthroscopically and would be a clinically effective method for cartilage repair and healing.

Cite This Article

APA
Fortier LA, Potter HG, Rickey EJ, Schnabel LV, Foo LF, Chong LR, Stokol T, Cheetham J, Nixon AJ. (2010). Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model. J Bone Joint Surg Am, 92(10), 1927-1937. https://doi.org/10.2106/JBJS.I.01284

Publication

The Journal of bone and joint surgery. American volume
ISSN: 1535-1386
NlmUniqueID: 0014030
Country: United States
Language: English
Volume: 92
Issue: 10
Pages: 1927-1937

Researcher Affiliations

Fortier, Lisa A
  • Departments of Clinical Sciences, VMC C3-181, Cornell University, Ithaca, NY 14853, USA. laf4@cornell.edu
Potter, Hollis G
    Rickey, Ellen J
      Schnabel, Lauren V
        Foo, Li Foong
          Chong, Leroy R
            Stokol, Tracy
              Cheetham, Jon
                Nixon, Alan J

                  MeSH Terms

                  • Animals
                  • Arthroplasty, Subchondral
                  • Bone Marrow Transplantation
                  • Cartilage, Articular / injuries
                  • Cartilage, Articular / surgery
                  • Flow Cytometry
                  • Horses
                  • Magnetic Resonance Imaging
                  • Treatment Outcome
                  • Wound Healing / physiology

                  Citations

                  This article has been cited 118 times.
                  1. Pezzanite LM, Timkovich AE, Sikes KJ, Chow L, Hendrickson DA, Becker JR, Webster A, Santangelo KS, Dow S. Erythrocyte removal from bone marrow aspirate concentrate improves efficacy as intra-articular cellular therapy in a rodent osteoarthritis model.. Ann Transl Med 2023 Jun 30;11(9):311.
                    doi: 10.21037/atm-22-4256pubmed: 37404993google scholar: lookup
                  2. Jammes M, Contentin R, Cassé F, Galéra P. Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies.. Front Vet Sci 2023;10:1115774.
                    doi: 10.3389/fvets.2023.1115774pubmed: 36846261google scholar: lookup
                  3. Iida K, Hashimoto Y, Orita K, Nishino K, Kinoshita T, Nakamura H. The Potential of Using an Autogenous Tendon Graft by Injecting Bone Marrow Aspirate in a Rabbit Meniscectomy Model.. Int J Mol Sci 2022 Oct 18;23(20).
                    doi: 10.3390/ijms232012458pubmed: 36293313google scholar: lookup
                  4. Lai WC, Bohlen HL, Fackler NP, Wang D. Osteochondral Allografts in Knee Surgery: Narrative Review of Evidence to Date.. Orthop Res Rev 2022;14:263-274.
                    doi: 10.2147/ORR.S253761pubmed: 35979427google scholar: lookup
                  5. Abas S, Kuiper JH, Roberts S, McCarthy H, Williams M, Bing A, Tins B, Makwana N. Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study.. Cells 2022 Feb 11;11(4).
                    doi: 10.3390/cells11040629pubmed: 35203279google scholar: lookup
                  6. Massey PA, McClary KN, McBride HD, Walt J, Mielke CH, Barton RS. Arthroscopic Fixation of Knee Femoral Condyle Osteochondritis Dissecans Fragment With Bone Marrow Aspirate Concentrate.. Arthrosc Tech 2021 Oct;10(10):e2357-e2363.
                    doi: 10.1016/j.eats.2021.07.013pubmed: 34754745google scholar: lookup
                  7. Maleas G, Mageed M. Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy.. Front Vet Sci 2021;8:678453.
                    doi: 10.3389/fvets.2021.678453pubmed: 34222402google scholar: lookup
                  8. Dávila Castrodad IM, Simone ES, Kurowicki J, Melendez JX, Mease SJ, McInerney VK, Scillia AJ. Improved Short-Term Outcomes of Osteochondral Lesions of the Knee Following Arthroscopic Treatment With Bone Marrow Aspirate Concentrate and Cartilage-Derived Matrix.. Arthrosc Sports Med Rehabil 2021 Apr;3(2):e477-e484.
                    doi: 10.1016/j.asmr.2020.11.002pubmed: 34027458google scholar: lookup
                  9. Kruel AVS, Ribeiro LL, Gusmão PD, Huber SC, Lana JFSD. Orthobiologics in the treatment of hip disorders.. World J Stem Cells 2021 Apr 26;13(4):304-316.
                    doi: 10.4252/wjsc.v13.i4.304pubmed: 33959220google scholar: lookup
                  10. Hinckel BB, Thomas D, Vellios EE, Hancock KJ, Calcei JG, Sherman SL, Eliasberg CD, Fernandes TL, Farr J, Lattermann C, Gomoll AH. Algorithm for Treatment of Focal Cartilage Defects of the Knee: Classic and New Procedures.. Cartilage 2021 Dec;13(1_suppl):473S-495S.
                    doi: 10.1177/1947603521993219pubmed: 33745340google scholar: lookup
                  11. DeFroda SF, Cregar W, Vadhera A, Singh H, Perry A, Chahla J. Arthroscopic Autologous Chondrocyte Bone Grafting of a Lateral Tibial Plateau Chondral Defect.. Arthrosc Tech 2021 Mar;10(3):e861-e865.
                    doi: 10.1016/j.eats.2020.10.078pubmed: 33738225google scholar: lookup
                  12. Laurent A, Abdel-Sayed P, Ducrot A, Hirt-Burri N, Scaletta C, Jaccoud S, Nuss K, Roessingh ASB, Raffoul W, Pioletti D, Rechenberg BV, Applegate LA, Darwiche S. Development of Standardized Fetal Progenitor Cell Therapy for Cartilage Regenerative Medicine: Industrial Transposition and Preliminary Safety in Xenogeneic Transplantation.. Biomolecules 2021 Feb 9;11(2).
                    doi: 10.3390/biom11020250pubmed: 33572428google scholar: lookup
                  13. Ruediger T, Horbert V, Reuther A, Kumar Kalla P, Burgkart RH, Walther M, Kinne RW, Mika J. Thickness of the Stifle Joint Articular Cartilage in Different Large Animal Models of Cartilage Repair and Regeneration.. Cartilage 2021 Dec;13(2_suppl):438S-452S.
                    doi: 10.1177/1947603520976763pubmed: 33269611google scholar: lookup
                  14. Potyondy T, Uquillas JA, Tebon PJ, Byambaa B, Hasan A, Tavafoghi M, Mary H, Aninwene GE 2nd, Pountos I, Khademhosseini A, Ashammakhi N. Recent advances in 3D bioprinting of musculoskeletal tissues.. Biofabrication 2021 Mar 10;13(2).
                    doi: 10.1088/1758-5090/abc8depubmed: 33166949google scholar: lookup
                  15. Dávila Castrodad IM, Mease SJ, Werheim E, McInerney VK, Scillia AJ. Arthroscopic Chondral Defect Repair With Extracellular Matrix Scaffold and Bone Marrow Aspirate Concentrate.. Arthrosc Tech 2020 Sep;9(9):e1241-e1247.
                    doi: 10.1016/j.eats.2020.05.001pubmed: 33024662google scholar: lookup
                  16. Ryu DJ, Jeon YS, Park JS, Bae GC, Kim JS, Kim MK. Comparison of Bone Marrow Aspirate Concentrate and Allogenic Human Umbilical Cord Blood Derived Mesenchymal Stem Cell Implantation on Chondral Defect of Knee: Assessment of Clinical and Magnetic Resonance Imaging Outcomes at 2-Year Follow-Up.. Cell Transplant 2020 Jan-Dec;29:963689720943581.
                    doi: 10.1177/0963689720943581pubmed: 32713192google scholar: lookup
                  17. Shah SS, Mithoefer K. Current Applications of Growth Factors for Knee Cartilage Repair and Osteoarthritis Treatment.. Curr Rev Musculoskelet Med 2020 Dec;13(6):641-650.
                    doi: 10.1007/s12178-020-09664-6pubmed: 32710292google scholar: lookup
                  18. Cavallo C, Boffa A, Andriolo L, Silva S, Grigolo B, Zaffagnini S, Filardo G. Bone marrow concentrate injections for the treatment of osteoarthritis: evidence from preclinical findings to the clinical application.. Int Orthop 2021 Feb;45(2):525-538.
                    doi: 10.1007/s00264-020-04703-wpubmed: 32661635google scholar: lookup
                  19. Kim GB, Seo MS, Park WT, Lee GW. Bone Marrow Aspirate Concentrate: Its Uses in Osteoarthritis.. Int J Mol Sci 2020 May 2;21(9).
                    doi: 10.3390/ijms21093224pubmed: 32370163google scholar: lookup
                  20. Chen YR, Yan X, Yuan FZ, Ye J, Xu BB, Zhou ZX, Mao ZM, Guan J, Song YF, Sun ZW, Wang XJ, Chen ZY, Wang DY, Fan BS, Yang M, Song ST, Jiang D, Yu JK. The Use of Peripheral Blood-Derived Stem Cells for Cartilage Repair and Regeneration In Vivo: A Review.. Front Pharmacol 2020;11:404.
                    doi: 10.3389/fphar.2020.00404pubmed: 32308625google scholar: lookup
                  21. Commins J, Irwin R, Matuska A, Goodale M, Delco M, Fortier L. Biological Mechanisms for Cartilage Repair Using a BioCartilage Scaffold: Cellular Adhesion/Migration and Bioactive Proteins.. Cartilage 2021 Dec;13(1_suppl):984S-992S.
                    doi: 10.1177/1947603519900803pubmed: 31965816google scholar: lookup
                  22. Fugazzola MC, van Weeren PR. Surgical osteochondral defect repair in the horse-a matter of form or function?. Equine Vet J 2020 Jul;52(4):489-499.
                    doi: 10.1111/evj.13231pubmed: 31958175google scholar: lookup
                  23. Toale J, Shimozono Y, Mulvin C, Dahmen J, Kerkhoffs GMMJ, Kennedy JG. Midterm Outcomes of Bone Marrow Stimulation for Primary Osteochondral Lesions of the Talus: A Systematic Review.. Orthop J Sports Med 2019 Oct;7(10):2325967119879127.
                    doi: 10.1177/2325967119879127pubmed: 31696137google scholar: lookup
                  24. Abdelrazik H, Giordano E, Barbanti Brodano G, Griffoni C, De Falco E, Pelagalli A. Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine.. Int J Mol Sci 2019 Oct 29;20(21).
                    doi: 10.3390/ijms20215386pubmed: 31671788google scholar: lookup
                  25. Magri C, Schramme M, Febre M, Cauvin E, Labadie F, Saulnier N, François I, Lechartier A, Aebischer D, Moncelet AS, Maddens S. Comparison of efficacy and safety of single versus repeated intra-articular injection of allogeneic neonatal mesenchymal stem cells for treatment of osteoarthritis of the metacarpophalangeal/metatarsophalangeal joint in horses: A clinical pilot study.. PLoS One 2019;14(8):e0221317.
                    doi: 10.1371/journal.pone.0221317pubmed: 31465445google scholar: lookup
                  26. Hu CH, Tseng YW, Chiou CY, Lan KC, Chou CH, Tai CS, Huang HD, Hu CW, Liao KH, Chuang SS, Yang JY, Lee OK. Bone marrow concentrate-induced mesenchymal stem cell conditioned medium facilitates wound healing and prevents hypertrophic scar formation in a rabbit ear model.. Stem Cell Res Ther 2019 Aug 28;10(1):275.
                    doi: 10.1186/s13287-019-1383-xpubmed: 31462299google scholar: lookup
                  27. Olesen ML, Christensen BB, Foldager CB, Hede KC, Jørgensen NL, Lind M. No Effect of Platelet-Rich Plasma Injections as an Adjuvant to Autologous Cartilage Chips Implantation for the Treatment of Chondral Defects.. Cartilage 2021 Dec;13(2_suppl):277S-284S.
                    doi: 10.1177/1947603519865318pubmed: 31327251google scholar: lookup
                  28. Gugjoo MB, Fazili MR, Gayas MA, Ahmad RA, Dhama K. Animal mesenchymal stem cell research in cartilage regenerative medicine - a review.. Vet Q 2019 Dec;39(1):95-120.
                    doi: 10.1080/01652176.2019.1643051pubmed: 31291836google scholar: lookup
                  29. Gale AL, Linardi RL, McClung G, Mammone RM, Ortved KF. Comparison of the Chondrogenic Differentiation Potential of Equine Synovial Membrane-Derived and Bone Marrow-Derived Mesenchymal Stem Cells.. Front Vet Sci 2019;6:178.
                    doi: 10.3389/fvets.2019.00178pubmed: 31245393google scholar: lookup
                  30. Stewart RC, Nelson BB, Kawcak CE, Freedman JD, Snyder BD, Goodrich LR, Grinstaff MW. Contrast-Enhanced Computed Tomography Scoring System for Distinguishing Early Osteoarthritis Disease States: A Feasibility Study.. J Orthop Res 2019 Oct;37(10):2138-2148.
                    doi: 10.1002/jor.24382pubmed: 31136003google scholar: lookup
                  31. Vayas R, Reyes R, Arnau MR, Évora C, Delgado A. Injectable Scaffold for Bone Marrow Stem Cells and Bone Morphogenetic Protein-2 to Repair Cartilage.. Cartilage 2021 Jul;12(3):293-306.
                    doi: 10.1177/1947603519841682pubmed: 30971092google scholar: lookup
                  32. Apostolakos JM, Lazaro L, Williams RJ. The Use of Bone Marrow Concentrate in the Treatment of Full-Thickness Chondral Defects.. HSS J 2019 Feb;15(1):96-99.
                    doi: 10.1007/s11420-018-9647-zpubmed: 30863240google scholar: lookup
                  33. de Girolamo L, Ragni E, Cucchiarini M, van Bergen CJA, Hunziker EB, Chubinskaya S. Cells, soluble factors and matrix harmonically play the concert of allograft integration.. Knee Surg Sports Traumatol Arthrosc 2019 Jun;27(6):1717-1725.
                    doi: 10.1007/s00167-018-5182-1pubmed: 30291395google scholar: lookup
                  34. Shieh AK, Singh SG, Nathe C, Lian E, Haudenschild DR, Nolta JA, Lee CA, Giza E, Kreulen CD. Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus.. Cartilage 2020 Jul;11(3):316-322.
                    doi: 10.1177/1947603518796125pubmed: 30156865google scholar: lookup
                  35. Imam MA, Mahmoud SSS, Holton J, Abouelmaati D, Elsherbini Y, Snow M. A systematic review of the concept and clinical applications of Bone Marrow Aspirate Concentrate in Orthopaedics.. SICOT J 2017;3:17.
                    doi: 10.1051/sicotj/2017007pubmed: 29792397google scholar: lookup
                  36. Bogers SH. Cell-Based Therapies for Joint Disease in Veterinary Medicine: What We Have Learned and What We Need to Know.. Front Vet Sci 2018;5:70.
                    doi: 10.3389/fvets.2018.00070pubmed: 29713634google scholar: lookup
                  37. Barboni B, Russo V, Berardinelli P, Mauro A, Valbonetti L, Sanyal H, Canciello A, Greco L, Muttini A, Gatta V, Stuppia L, Mattioli M. Placental Stem Cells from Domestic Animals: Translational Potential and Clinical Relevance.. Cell Transplant 2018 Jan;27(1):93-116.
                    doi: 10.1177/0963689717724797pubmed: 29562773google scholar: lookup
                  38. Hussein H, Boyaka P, Dulin J, Russell D, Smanik L, Azab M, Bertone AL. Cathepsin K Localizes to Equine Bone In Vivo and Inhibits Bone Marrow Stem and Progenitor Cells Differentiation In Vitro.. J Stem Cells Regen Med 2017;13(2):45-53.
                    doi: 10.46582/jsrm.1302008pubmed: 29391749google scholar: lookup
                  39. Chu CR, Fortier LA, Williams A, Payne KA, McCarrel TM, Bowers ME, Jaramillo D. Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A One-Year Study in an Equine Model.. J Bone Joint Surg Am 2018 Jan 17;100(2):138-146.
                    doi: 10.2106/JBJS.17.00132pubmed: 29342064google scholar: lookup
                  40. Arshi A, Fabricant PD, Go DE, Williams RJ, McAllister DR, Jones KJ. Can Biologic Augmentation Improve Clinical Outcomes Following Microfracture for Symptomatic Cartilage Defects of the Knee? A Systematic Review.. Cartilage 2018 Apr;9(2):146-155.
                    doi: 10.1177/1947603517746722pubmed: 29241343google scholar: lookup
                  41. Cotter EJ, Wang KC, Yanke AB, Chubinskaya S. Bone Marrow Aspirate Concentrate for Cartilage Defects of the Knee: From Bench to Bedside Evidence.. Cartilage 2018 Apr;9(2):161-170.
                    doi: 10.1177/1947603517741169pubmed: 29126349google scholar: lookup
                  42. Imam MA, Holton J, Horriat S, Negida AS, Grubhofer F, Gupta R, Narvani A, Snow M. A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology.. SICOT J 2017;3:58.
                    doi: 10.1051/sicotj/2017039pubmed: 28990575google scholar: lookup
                  43. McCarrel TM, Pownder SL, Gilbert S, Koff MF, Castiglione E, Saska RA, Bradica G, Fortier LA. Two-Year Evaluation of Osteochondral Repair with a Novel Biphasic Graft Saturated in Bone Marrow in an Equine Model.. Cartilage 2017 Oct;8(4):406-416.
                    doi: 10.1177/1947603516675913pubmed: 28934879google scholar: lookup
                  44. Oliver K, Awan T, Bayes M. Single- Versus Multiple-Site Harvesting Techniques for Bone Marrow Concentrate: Evaluation of Aspirate Quality and Pain.. Orthop J Sports Med 2017 Aug;5(8):2325967117724398.
                    doi: 10.1177/2325967117724398pubmed: 28890905google scholar: lookup
                  45. Moatshe G, Morris ER, Cinque ME, Pascual-Garrido C, Chahla J, Engebretsen L, Laprade RF. Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates.. Acta Orthop 2017 Dec;88(6):670-674.
                    doi: 10.1080/17453674.2017.1368899pubmed: 28831830google scholar: lookup
                  46. Gianakos AL, Sun L, Patel JN, Adams DM, Liporace FA. Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review.. World J Orthop 2017 Jun 18;8(6):491-506.
                    doi: 10.5312/wjo.v8.i6.491pubmed: 28660142google scholar: lookup
                  47. Madry H, Gao L, Eichler H, Orth P, Cucchiarini M. Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects.. Stem Cells Int 2017;2017:1609685.
                    doi: 10.1155/2017/1609685pubmed: 28607559google scholar: lookup
                  48. Hayashi D, Li X, Murakami AM, Roemer FW, Trattnig S, Guermazi A. Understanding Magnetic Resonance Imaging of Knee Cartilage Repair: A Focus on Clinical Relevance.. Cartilage 2018 Jul;9(3):223-236.
                    doi: 10.1177/1947603517710309pubmed: 28580842google scholar: lookup
                  49. Chahla J, Mannava S, Cinque ME, Geeslin AG, Codina D, LaPrade RF. Bone Marrow Aspirate Concentrate Harvesting and Processing Technique.. Arthrosc Tech 2017 Apr;6(2):e441-e445.
                    doi: 10.1016/j.eats.2016.10.024pubmed: 28580265google scholar: lookup
                  50. McDaniel JS, Antebi B, Pilia M, Hurtgen BJ, Belenkiy S, Necsoiu C, Cancio LC, Rathbone CR, Batchinsky AI. Quantitative Assessment of Optimal Bone Marrow Site for the Isolation of Porcine Mesenchymal Stem Cells.. Stem Cells Int 2017;2017:1836960.
                    doi: 10.1155/2017/1836960pubmed: 28539939google scholar: lookup
                  51. Gao F, Chen N, Sun W, Wang B, Shi Z, Cheng L, Li Z, Guo W. Combined Therapy with Shock Wave and Retrograde Bone Marrow-Derived Cell Transplantation for Osteochondral Lesions of the Talus.. Sci Rep 2017 May 18;7(1):2106.
                    doi: 10.1038/s41598-017-02378-9pubmed: 28522857google scholar: lookup
                  52. Dorcemus DL, George EO, Dealy CN, Nukavarapu SP. (*) Harnessing External Cues: Development and Evaluation of an In Vitro Culture System for Osteochondral Tissue Engineering.. Tissue Eng Part A 2017 Aug;23(15-16):719-737.
                    doi: 10.1089/ten.tea.2016.0439pubmed: 28346796google scholar: lookup
                  53. Gao L, Orth P, Müller-Brandt K, Goebel LK, Cucchiarini M, Madry H. Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair.. Sci Rep 2017 Mar 27;7:45189.
                    doi: 10.1038/srep45189pubmed: 28345610google scholar: lookup
                  54. Bertone AL, Reisbig NA, Kilborne AH, Kaido M, Salmanzadeh N, Lovasz R, Sizemore JL, Scheuermann L, Kopp RJ, Zekas LJ, Brokken MT. Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial.. Front Vet Sci 2017;4:31.
                    doi: 10.3389/fvets.2017.00031pubmed: 28344975google scholar: lookup
                  55. Zhang K, Jiang Y, Du J, Tao T, Li W, Li Y, Gui J. Comparison of distraction arthroplasty alone versus combined with arthroscopic microfracture in treatment of post-traumatic ankle arthritis.. J Orthop Surg Res 2017 Mar 17;12(1):45.
                    doi: 10.1186/s13018-017-0546-7pubmed: 28302130google scholar: lookup
                  56. Goldberg A, Mitchell K, Soans J, Kim L, Zaidi R. The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review.. J Orthop Surg Res 2017 Mar 9;12(1):39.
                    doi: 10.1186/s13018-017-0534-ypubmed: 28279182google scholar: lookup
                  57. Shimozono Y, Yasui Y, Ross AW, Kennedy JG. Osteochondral lesions of the talus in the athlete: up to date review.. Curr Rev Musculoskelet Med 2017 Mar;10(1):131-140.
                    doi: 10.1007/s12178-017-9393-8pubmed: 28188546google scholar: lookup
                  58. Gianakos AL, Yasui Y, Hannon CP, Kennedy JG. Current management of talar osteochondral lesions.. World J Orthop 2017 Jan 18;8(1):12-20.
                    doi: 10.5312/wjo.v8.i1.12pubmed: 28144574google scholar: lookup
                  59. Desando G, Bartolotti I, Vannini F, Cavallo C, Castagnini F, Buda R, Giannini S, Mosca M, Mariani E, Grigolo B. Repair Potential of Matrix-Induced Bone Marrow Aspirate Concentrate and Matrix-Induced Autologous Chondrocyte Implantation for Talar Osteochondral Repair: Patterns of Some Catabolic, Inflammatory, and Pain Mediators.. Cartilage 2017 Jan;8(1):50-60.
                    doi: 10.1177/1947603516642573pubmed: 27994720google scholar: lookup
                  60. Yasui Y, Wollstein A, Murawski CD, Kennedy JG. Operative Treatment for Osteochondral Lesions of the Talus: Biologics and Scaffold-Based Therapy.. Cartilage 2017 Jan;8(1):42-49.
                    doi: 10.1177/1947603516644298pubmed: 27994719google scholar: lookup
                  61. Looze CA, Capo J, Ryan MK, Begly JP, Chapman C, Swanson D, Singh BC, Strauss EJ. Evaluation and Management of Osteochondral Lesions of the Talus.. Cartilage 2017 Jan;8(1):19-30.
                    doi: 10.1177/1947603516670708pubmed: 27994717google scholar: lookup
                  62. Prado MP, Kennedy JG, Raduan F, Nery C. Diagnosis and treatment of osteochondral lesions of the ankle: current concepts.. Rev Bras Ortop 2016 Sep-Oct;51(5):489-500.
                    doi: 10.1016/j.rboe.2016.08.007pubmed: 27818968google scholar: lookup
                  63. Chahla J, Cinque ME, Shon JM, Liechti DJ, Matheny LM, LaPrade RF, Clanton TO. Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes.. J Exp Orthop 2016 Dec;3(1):33.
                    doi: 10.1186/s40634-016-0069-xpubmed: 27813021google scholar: lookup
                  64. Maumus M, Roussignol G, Toupet K, Penarier G, Bentz I, Teixeira S, Oustric D, Jung M, Lepage O, Steinberg R, Jorgensen C, Noel D. Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFNγ-Primed Equine Mesenchymal Stem Cells.. Front Immunol 2016;7:392.
                    doi: 10.3389/fimmu.2016.00392pubmed: 27729913google scholar: lookup
                  65. Huh SW, Shetty AA, Ahmed S, Lee DH, Kim SJ. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC).. J Clin Orthop Trauma 2016 Jul-Sep;7(3):153-6.
                    doi: 10.1016/j.jcot.2016.05.004pubmed: 27489409google scholar: lookup
                  66. Holton J, Imam MA, Snow M. Bone Marrow Aspirate in the Treatment of Chondral Injuries.. Front Surg 2016;3:33.
                    doi: 10.3389/fsurg.2016.00033pubmed: 27379241google scholar: lookup
                  67. Chu CR. The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair.. Cartilage 2015 Apr;6(2 Suppl):36S-45S.
                    doi: 10.1177/1947603515574839pubmed: 27340515google scholar: lookup
                  68. Kim YS, Lee M, Koh YG. Additional mesenchymal stem cell injection improves the outcomes of marrow stimulation combined with supramalleolar osteotomy in varus ankle osteoarthritis: short-term clinical results with second-look arthroscopic evaluation.. J Exp Orthop 2016 Dec;3(1):12.
                    doi: 10.1186/s40634-016-0048-2pubmed: 27206975google scholar: lookup
                  69. Chen C, Bang S, Cho Y, Lee S, Lee I, Zhang S, Noh I. Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone.. Biomater Res 2016;20:10.
                    doi: 10.1186/s40824-016-0057-3pubmed: 27148455google scholar: lookup
                  70. Zlotnicki JP, Geeslin AG, Murray IR, Petrigliano FA, LaPrade RF, Mann BJ, Musahl V. Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 3: Articular Cartilage.. Orthop J Sports Med 2016 Apr;4(4):2325967116642433.
                    doi: 10.1177/2325967116642433pubmed: 27123466google scholar: lookup
                  71. Peters AE, Watts AE. Biopsy Needle Advancement during Bone Marrow Aspiration Increases Mesenchymal Stem Cell Concentration.. Front Vet Sci 2016;3:23.
                    doi: 10.3389/fvets.2016.00023pubmed: 27014705google scholar: lookup
                  72. Cassano JM, Kennedy JG, Ross KA, Fraser EJ, Goodale MB, Fortier LA. Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration.. Knee Surg Sports Traumatol Arthrosc 2018 Jan;26(1):333-342.
                    doi: 10.1007/s00167-016-3981-9pubmed: 26831858google scholar: lookup
                  73. Walls RJ, Ross KA, Fraser EJ, Hodgkins CW, Smyth NA, Egan CJ, Calder J, Kennedy JG. Football injuries of the ankle: A review of injury mechanisms, diagnosis and management.. World J Orthop 2016 Jan 18;7(1):8-19.
                    doi: 10.5312/wjo.v7.i1.8pubmed: 26807351google scholar: lookup
                  74. Chahla J, Dean CS, Moatshe G, Pascual-Garrido C, Serra Cruz R, LaPrade RF. Concentrated Bone Marrow Aspirate for the Treatment of Chondral Injuries and Osteoarthritis of the Knee: A Systematic Review of Outcomes.. Orthop J Sports Med 2016 Jan;4(1):2325967115625481.
                    doi: 10.1177/2325967115625481pubmed: 26798765google scholar: lookup
                  75. Goodrich LR, Chen AC, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR. Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair?. J Bone Joint Surg Am 2016 Jan 6;98(1):23-34.
                    doi: 10.2106/JBJS.O.00407pubmed: 26738900google scholar: lookup
                  76. Siebold R, Karidakis G, Feil S, Fernandez F. Second-look assessment after all-arthroscopic autologous chondrocyte implantation with spheroides at the knee joint.. Knee Surg Sports Traumatol Arthrosc 2016 May;24(5):1678-85.
                    doi: 10.1007/s00167-015-3822-2pubmed: 26704798google scholar: lookup
                  77. Luangphakdy V, Boehm C, Pan H, Herrick J, Zaveri P, Muschler GF. Assessment of Methods for Rapid Intraoperative Concentration and Selection of Marrow-Derived Connective Tissue Progenitors for Bone Regeneration Using the Canine Femoral Multidefect Model.. Tissue Eng Part A 2016 Jan;22(1-2):17-30.
                    doi: 10.1089/ten.TEA.2014.0663pubmed: 26538088google scholar: lookup
                  78. Veronesi F, Cadossi M, Giavaresi G, Martini L, Setti S, Buda R, Giannini S, Fini M. Pulsed electromagnetic fields combined with a collagenous scaffold and bone marrow concentrate enhance osteochondral regeneration: an in vivo study.. BMC Musculoskelet Disord 2015 Sep 2;16:233.
                    doi: 10.1186/s12891-015-0683-2pubmed: 26328626google scholar: lookup
                  79. Santos AL, Demange MK, Prado MP, Fernandes TD, Giglio PN, Hintermann B. Cartilage lesions and ankle osteoarthrosis: review of the literature and treatment algorithm.. Rev Bras Ortop 2014 Nov-Dec;49(6):565-72.
                    doi: 10.1016/j.rboe.2014.11.003pubmed: 26229863google scholar: lookup
                  80. O'Brien MP, Penmatsa M, Palukuru U, West P, Yang X, Bostrom MP, Freeman T, Pleshko N. Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy.. Cartilage 2015 Jul;6(3):174-84.
                    doi: 10.1177/1947603515572874pubmed: 26175863google scholar: lookup
                  81. Gobbi A, Chaurasia S, Karnatzikos G, Nakamura N. Matrix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the Treatment of Large Patellofemoral Chondral Lesions: A Nonrandomized Prospective Trial.. Cartilage 2015 Apr;6(2):82-97.
                    doi: 10.1177/1947603514563597pubmed: 26069711google scholar: lookup
                  82. Shive MS, Stanish WD, McCormack R, Forriol F, Mohtadi N, Pelet S, Desnoyers J, Méthot S, Vehik K, Restrepo A. BST-CarGel® Treatment Maintains Cartilage Repair Superiority over Microfracture at 5 Years in a Multicenter Randomized Controlled Trial.. Cartilage 2015 Apr;6(2):62-72.
                    doi: 10.1177/1947603514562064pubmed: 26069709google scholar: lookup
                  83. Lee YH, Suzer F, Thermann H. Autologous Matrix-Induced Chondrogenesis in the Knee: A Review.. Cartilage 2014 Jul;5(3):145-53.
                    doi: 10.1177/1947603514529445pubmed: 26069694google scholar: lookup
                  84. Grande DA, Schwartz JA, Brandel E, Chahine NO, Sgaglione N. Articular Cartilage Repair: Where We Have Been, Where We Are Now, and Where We Are Headed.. Cartilage 2013 Oct;4(4):281-5.
                    doi: 10.1177/1947603513494402pubmed: 26069673google scholar: lookup
                  85. Getgood A, Henson F, Skelton C, Herrera E, Brooks R, Fortier LA, Rushton N. The Augmentation of a Collagen/Glycosaminoglycan Biphasic Osteochondral Scaffold with Platelet-Rich Plasma and Concentrated Bone Marrow Aspirate for Osteochondral Defect Repair in Sheep: A Pilot Study.. Cartilage 2012 Oct;3(4):351-63.
                    doi: 10.1177/1947603512444597pubmed: 26069645google scholar: lookup
                  86. McIlwraith CW, Fortier LA, Frisbie DD, Nixon AJ. Equine Models of Articular Cartilage Repair.. Cartilage 2011 Oct;2(4):317-26.
                    doi: 10.1177/1947603511406531pubmed: 26069590google scholar: lookup
                  87. Hoemann C, Kandel R, Roberts S, Saris DB, Creemers L, Mainil-Varlet P, Méthot S, Hollander AP, Buschmann MD. International Cartilage Repair Society (ICRS) Recommended Guidelines for Histological Endpoints for Cartilage Repair Studies in Animal Models and Clinical Trials.. Cartilage 2011 Apr;2(2):153-72.
                    doi: 10.1177/1947603510397535pubmed: 26069577google scholar: lookup
                  88. Hurtig MB, Buschmann MD, Fortier LA, Hoemann CD, Hunziker EB, Jurvelin JS, Mainil-Varlet P, McIlwraith CW, Sah RL, Whiteside RA. Preclinical Studies for Cartilage Repair: Recommendations from the International Cartilage Repair Society.. Cartilage 2011 Apr;2(2):137-52.
                    doi: 10.1177/1947603511401905pubmed: 26069576google scholar: lookup
                  89. Trattnig S, Winalski CS, Marlovits S, Jurvelin JS, Welsch GH, Potter HG. Magnetic Resonance Imaging of Cartilage Repair: A Review.. Cartilage 2011 Jan;2(1):5-26.
                    doi: 10.1177/1947603509360209pubmed: 26069565google scholar: lookup
                  90. Smith B, Goldstein T, Ekstein C. Biologic adjuvants and bone: current use in orthopedic surgery.. Curr Rev Musculoskelet Med 2015 Jun;8(2):193-9.
                    doi: 10.1007/s12178-015-9265-zpubmed: 25804684google scholar: lookup
                  91. Murray IR, Benke MT, Mandelbaum BR. Management of knee articular cartilage injuries in athletes: chondroprotection, chondrofacilitation, and resurfacing.. Knee Surg Sports Traumatol Arthrosc 2016 May;24(5):1617-26.
                    doi: 10.1007/s00167-015-3509-8pubmed: 25661676google scholar: lookup
                  92. Yanke AB, Chubinskaya S. The state of cartilage regeneration: current and future technologies.. Curr Rev Musculoskelet Med 2015 Mar;8(1):1-8.
                    doi: 10.1007/s12178-014-9254-7pubmed: 25591739google scholar: lookup
                  93. Grissom MJ, Temple-Wong MM, Adams MS, Tom M, Schumacher BL, McIlwraith CW, Goodrich LR, Chu CR, Sah RL. Synovial Fluid Lubricant Properties are Transiently Deficient after Arthroscopic Articular Cartilage Defect Repair with Platelet-Enriched Fibrin Alone and with Mesenchymal Stem Cells.. Orthop J Sports Med 2014 Jul;2(7).
                    doi: 10.1177/2325967114542580pubmed: 25530978google scholar: lookup
                  94. Jang Y, Koh YG, Choi YJ, Kim SH, Yoon DS, Lee M, Lee JW. Characterization of adipose tissue-derived stromal vascular fraction for clinical application to cartilage regeneration.. In Vitro Cell Dev Biol Anim 2015 Feb;51(2):142-50.
                    doi: 10.1007/s11626-014-9814-6pubmed: 25361717google scholar: lookup
                  95. Miller RE, Grodzinsky AJ, Barrett MF, Hung HH, Frank EH, Werpy NM, McIlwraith CW, Frisbie DD. Effects of the combination of microfracture and self-assembling Peptide filling on the repair of a clinically relevant trochlear defect in an equine model.. J Bone Joint Surg Am 2014 Oct 1;96(19):1601-9.
                    doi: 10.2106/JBJS.M.01408pubmed: 25274785google scholar: lookup
                  96. Baums MH, Schultz W, Kostuj T, Klinger HM. Cartilage repair techniques of the talus: An update.. World J Orthop 2014 Jul 18;5(3):171-9.
                    doi: 10.5312/wjo.v5.i3.171pubmed: 25035819google scholar: lookup
                  97. Steinwachs MR, Waibl B, Wopperer S, Mumme M. Matrix-associated chondroplasty: a novel platelet-rich plasma and concentrated nucleated bone marrow cell-enhanced cartilage restoration technique.. Arthrosc Tech 2014 Apr;3(2):e279-82.
                    doi: 10.1016/j.eats.2014.01.002pubmed: 24904777google scholar: lookup
                  98. Betsch M, Thelen S, Santak L, Herten M, Jungbluth P, Miersch D, Hakimi M, Wild M. The role of erythropoietin and bone marrow concentrate in the treatment of osteochondral defects in mini-pigs.. PLoS One 2014;9(3):e92766.
                    doi: 10.1371/journal.pone.0092766pubmed: 24676029google scholar: lookup
                  99. Anderson JA, Little D, Toth AP, Moorman CT 3rd, Tucker BS, Ciccotti MG, Guilak F. Stem cell therapies for knee cartilage repair: the current status of preclinical and clinical studies.. Am J Sports Med 2014 Sep;42(9):2253-61.
                    doi: 10.1177/0363546513508744pubmed: 24220016google scholar: lookup
                  100. Tsuzuki N, Seo JP, Yamada K, Haneda S, Furuoka H, Tabata Y, Sasaki N. The effect of a gelatin β-tricalcium phosphate sponge loaded with mesenchymal stem cells (MSC), bone morphogenic protein-2, and platelet-rich plasma (PRP) on equine articular cartilage defect.. Can Vet J 2013 Jun;54(6):573-80.
                    pubmed: 24155448
                  101. Myers KR, Sgaglione NA, Grande DA. Trends in biological joint resurfacing.. Bone Joint Res 2013;2(9):193-9.
                    doi: 10.1302/2046-3758.29.2000189pubmed: 24043640google scholar: lookup
                  102. Gigante A, Cecconi S, Calcagno S, Busilacchi A, Enea D. Arthroscopic knee cartilage repair with covered microfracture and bone marrow concentrate.. Arthrosc Tech 2012 Dec;1(2):e175-80.
                    doi: 10.1016/j.eats.2012.07.001pubmed: 23766992google scholar: lookup
                  103. Tetta C, Consiglio AL, Bruno S, Tetta E, Gatti E, Dobreva M, Cremonesi F, Camussi G. The role of microvesicles derived from mesenchymal stem cells in tissue regeneration; a dream for tendon repair?. Muscles Ligaments Tendons J 2012 Jul;2(3):212-21.
                    pubmed: 23738299
                  104. Watts AE, Ackerman-Yost JC, Nixon AJ. A comparison of three-dimensional culture systems to evaluate in vitro chondrogenesis of equine bone marrow-derived mesenchymal stem cells.. Tissue Eng Part A 2013 Oct;19(19-20):2275-83.
                    doi: 10.1089/ten.TEA.2012.0479pubmed: 23725547google scholar: lookup
                  105. Tuan RS, Chen AF, Klatt BA. Cartilage regeneration.. J Am Acad Orthop Surg 2013 May;21(5):303-11.
                    doi: 10.5435/JAAOS-21-05-303pubmed: 23637149google scholar: lookup
                  106. Cyranoski D. Stem cells boom in vet clinics.. Nature 2013 Apr 11;496(7444):148-9.
                    doi: 10.1038/496148apubmed: 23579655google scholar: lookup
                  107. Potter HG, Koff MF. MR Imaging Tools to Assess Cartilage and Joint Structures.. HSS J 2012 Feb;8(1):29-32.
                    doi: 10.1007/s11420-011-9241-0pubmed: 23372524google scholar: lookup
                  108. Filardo G, Madry H, Jelic M, Roffi A, Cucchiarini M, Kon E. Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.. Knee Surg Sports Traumatol Arthrosc 2013 Aug;21(8):1717-29.
                    doi: 10.1007/s00167-012-2329-3pubmed: 23306713google scholar: lookup
                  109. Zhao Q, Wang S, Tian J, Wang L, Dong S, Xia T, Wu Z. Combination of bone marrow concentrate and PGA scaffolds enhance bone marrow stimulation in rabbit articular cartilage repair.. J Mater Sci Mater Med 2013 Mar;24(3):793-801.
                    doi: 10.1007/s10856-012-4841-xpubmed: 23274630google scholar: lookup
                  110. Campbell KJ, Boykin RE, Wijdicks CA, Erik Giphart J, LaPrade RF, Philippon MJ. Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy.. Knee Surg Sports Traumatol Arthrosc 2013 Jul;21(7):1684-8.
                    doi: 10.1007/s00167-012-2232-ypubmed: 23052123google scholar: lookup
                  111. Dave LY, Nyland J, McKee PB, Caborn DN. Mesenchymal stem cell therapy in the sports knee: where are we in 2011?. Sports Health 2012 May;4(3):252-7.
                    doi: 10.1177/1941738111427250pubmed: 23016095google scholar: lookup
                  112. Breton A, Sharma R, Diaz AC, Parham AG, Graham A, Neil C, Whitelaw CB, Milne E, Donadeu FX. Derivation and characterization of induced pluripotent stem cells from equine fibroblasts.. Stem Cells Dev 2013 Feb 15;22(4):611-21.
                    doi: 10.1089/scd.2012.0052pubmed: 22897112google scholar: lookup
                  113. Smyth NA, Murawski CD, Haleem AM, Hannon CP, Savage-Elliott I, Kennedy JG. Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus.. World J Orthop 2012 Jul 18;3(7):101-8.
                    doi: 10.5312/wjo.v3.i7.101pubmed: 22816065google scholar: lookup
                  114. Allon AA, Ng KW, Hammoud S, Russell BH, Jones CM, Rivera JJ, Schwartz J, Hook M, Maher SA. Augmenting the articular cartilage-implant interface: Functionalizing with a collagen adhesion protein.. J Biomed Mater Res A 2012 Aug;100(8):2168-75.
                    doi: 10.1002/jbm.a.34144pubmed: 22615182google scholar: lookup
                  115. Lamb J, Murawski CD, Deyer TW, Kennedy JG. Chevron-type medial malleolar osteotomy: a functional, radiographic and quantitative T2-mapping MRI analysis.. Knee Surg Sports Traumatol Arthrosc 2013 Jun;21(6):1283-8.
                    doi: 10.1007/s00167-012-2050-2pubmed: 22588694google scholar: lookup
                  116. Fortier LA, Barker JU, Strauss EJ, McCarrel TM, Cole BJ. The role of growth factors in cartilage repair.. Clin Orthop Relat Res 2011 Oct;469(10):2706-15.
                    doi: 10.1007/s11999-011-1857-3pubmed: 21403984google scholar: lookup
                  117. Fortier LA, Travis AJ. Stem cells in veterinary medicine.. Stem Cell Res Ther 2011 Feb 23;2(1):9.
                    doi: 10.1186/scrt50pubmed: 21371354google scholar: lookup
                  118. Farr J, Cole B, Dhawan A, Kercher J, Sherman S. Clinical cartilage restoration: evolution and overview.. Clin Orthop Relat Res 2011 Oct;469(10):2696-705.
                    doi: 10.1007/s11999-010-1764-zpubmed: 21240578google scholar: lookup
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