Concentration of methylprednisolone in the centrodistal joint after administration of methylprednisolone acetate in the tarsometatarsal joint.
Abstract: The centrodistal (CD) and tarsometatarsal (TMT) joints are often injected individually with a corticosteroid to resolve lameness caused by osteoarthritis (OA). There are no data available regarding diffusion of methylprednisolone (MP) from the TMT joint to the CD joint. Objective: A therapeutic concentration of MP diffuses into the CD joint after methylprednisolone acetate (MPA) is administered into the TMT joint. Objective: To measure the concentration of MP in the CD joint after MPA was administered into the TMT joint. Methods: MPA was administered into a TMT joint of 16 horses. At different times, the ipsilateral CD joint of these horses was injected with a small amount of saline and recovered saline was measured for concentration of MP using high performance liquid chromatography. Results: Six hours after administration of MPA into the TMT joint, a therapeutic concentration of MP was found in all 10 CD joints sampled at this time. Conclusions: Horses with pain arising from the distal 2 joints of the hock can be treated by administering MPA into the TMT joint alone. Conclusions: Administering MPA into the TMT joint only, to treat OA of the distal 2 hock joints, reduces the difficulties and risks associated with centesis of the CD joint.
Publication Date: 2005-03-23 PubMed ID: 15779632DOI: 10.2746/0425164054223778Google Scholar: Lookup
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- Journal Article
- Arthrocentesis
- Clinical Study
- Corticosteroids
- Diagnosis
- Disease Diagnosis
- Disease Treatment
- Drug
- Equine Health
- High-performance Liquid Chromatography (HPLC)
- Horses
- Intra-Articular Injection
- Joint Health
- Lameness
- Metatarsal Bones
- Osteoarthritis
- Pain Management
- Pharmacokinetics
- Tarsal Joint
- Veterinary Care
- Veterinary Medicine
Summary
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This research article investigates how a corticosteroid, methylprednisolone (MP), used to treat lameness in horses, diffuses from the tarsometatarsal (TMT) joint to the centrodistal (CD) joint. The results suggest that a therapeutic concentration of MP can reach the CD joint when administered into the TMT joint, which could simplify treatment and reduce risks associated with direct CD joint injection.
Research Concept And Aim
- The research revolves around the understanding of corticosteroid administration in horses suffering from lameness due to osteoarthritis (OA).
- The aim of the study was to measure the diffusion and concentration of MP (a corticosteroid) in the CD joint following administration in the TMT joint.
Methodology
- The study was conducted on 16 horses. Methylprednisolone acetate (MPA), an injectable form of MP, was delivered into the TMT joint of each horse.
- At different time points, a small amount of saline was injected into the CD joint on the same side (ipsilateral) and was later recovered to measure the concentration of MP.
- High-performance liquid chromatography, a technique in analytical chemistry, was used to measure the MP concentration.
Results
- 6 hours after administering MPA into the TMT joint, a therapeutic concentration of MP was found in all ten CD joint samples taken at that time.
Conclusions and Scientific Impact
- The findings offer a simpler and safer method for treating OA of the hock (a joint in the rear leg of the horse equivalent to the human ankle) by injecting MPA into the TMT joint only, rather than directly into the CD joint.
- Direct CD joint injection is more complex and carries risks (a procedure known as centesis), hence this indirect method reduces these challenges.
- This study provides valuable data on the diffusion of MP from one joint to another, which can inform better administration strategies for corticosteroids in veterinary medicine.
Cite This Article
APA
Serena A, Schumacher J, Schramme MC, Degraves F, Bell E, Ravis W.
(2005).
Concentration of methylprednisolone in the centrodistal joint after administration of methylprednisolone acetate in the tarsometatarsal joint.
Equine Vet J, 37(2), 172-174.
https://doi.org/10.2746/0425164054223778 Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
MeSH Terms
- Animals
- Anti-Inflammatory Agents / administration & dosage
- Anti-Inflammatory Agents / pharmacokinetics
- Cadaver
- Chromatography, High Pressure Liquid / veterinary
- Horse Diseases / drug therapy
- Horses
- Injections, Intra-Articular / veterinary
- Joints / chemistry
- Joints / metabolism
- Methylprednisolone / administration & dosage
- Methylprednisolone / analogs & derivatives
- Methylprednisolone / analysis
- Methylprednisolone / pharmacokinetics
- Methylprednisolone Acetate
- Osteoarthritis / drug therapy
- Osteoarthritis / veterinary
- Synovial Fluid / chemistry
- Synovial Fluid / metabolism
Citations
This article has been cited 2 times.- Pimentel KL, Carmalt JL. The Frequency of Communication Between the Synovial Compartments of the Equine Temporomandibular Joint: A Contrast-Enhanced Computed Tomographic Assessment.. Front Vet Sci 2021;8:753983.
- Al-Sobayil F, Sadan MA, El-Shafaey EA, Allouch J. Intra-articular injection in the hind limb joints of dromedary camels (Camelus dromedarius) using anatomical and arthrographic-guided landmarks.. Vet World 2021 Aug;14(8):2055-2063.
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