FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Acta Vet Scand / Concentration of serum prealbumin (PR) protein in sick horse...
Acta veterinaria Scandinavica1980; 21(4); 482-497; doi: 10.1186/BF03546836

Concentration of serum prealbumin (PR) protein in sick horses and its correlation to blood leucocyte count and albumin content in serum.

Abstract: Studies of Pr protein concentrations in sera of sick horses were carried out using ’s (1965) immunodiffusion technique. Relative values against a chosen standard of 100 were determined for a total of 102 horses. Horses with acute infections had Pr protein values significantly above the normal. The highest individual Pr protein value recorded in this group was 202. Horses suffering from acute laminitis and malignant tumours also had increased Pr protein values. There was a positive correlation between the Pr protein value and the blood leucocyte count and a negative correlation between the Pr protein value and the albumin content in serum. Det ble foretatt en undersøkelse av Pr protein-konsentrasjonene i sera fra syke hester ved hjelp av (1965) immundiffusjons-teknikk. Relative verdier i forhold til en valgt standard p 100 % ble besternt p et totalantall p 102 hester. Hester med akutte infeksjoner hadde Pr protein verdier som var signifikant høyere enn normale dyr. Den høyeste individuelle verdi som ble registrert i denne gruppen var 202. Hester med akutt forfangenhet og maligne svulster hadde også forhøyede Pr protein verdier i forhold til normale dyr. Det var en positiv korrelasjon mellom Pr protein verdien i serum og antallet leucocyter i blodet og en negativ korrelasjon mellom Pr protein verdien og albumininnholdet i serum.
Get Full Text
Publication Date: 1980-01-01 PubMed ID: 6784457PubMed Central: PMC8317751DOI: 10.1186/BF03546836Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the levels of prealbumin (PR) protein in the blood of horses and how these levels correlate with white blood cell count and albumin serum content, especially in horses suffering from acute infections, laminitis, and tumors.

Research Methodology

  • The research was conducted using immunodiffusion technique, a method established in 1965 which allows tracking and measuring of specific protein levels in blood.
  • The study was performed on a total of 102 horses. The values of Pr protein in the horses’ blood were measured and compared to a chosen standard value of 100.

Findings

  • The study found that horses with acute infections displayed significantly higher Pr protein levels than what is considered normal. The highest recorded Pr protein value in a horse from this group reached 202.
  • A similar trend of increased Pr protein levels was observed in horses suffering from acute laminitis (a painful condition affecting horses’ feet) and malignant tumors.

Correlations

  • The study also noted a positive correlation between Pr protein values and the blood leucocyte (white blood cell) count. This suggests that when the Pr protein level increases, the leucocyte count also generally increases.
  • On the other hand, a negative correlation was observed between Pr protein values and the albumin content in serum. This means an increase in Pr protein levels usually corresponds to a decrease in albumin serum content.

Conclusions and Implications

  • The results imply that Pr protein levels could potentially be used as an indicator of disease in horses – particularly acute infections, laminitis or malignant tumors.
  • The correlations found between Pr protein, leucocyte count, and albumin serum content could help measure and evaluate the severity of such conditions.

Cite This Article

APA
Ek N. (1980). Concentration of serum prealbumin (PR) protein in sick horses and its correlation to blood leucocyte count and albumin content in serum. Acta Vet Scand, 21(4), 482-497. https://doi.org/10.1186/BF03546836

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 21
Issue: 4
Pages: 482-497

Researcher Affiliations

Ek, N

    MeSH Terms

    • Animals
    • Horse Diseases / blood
    • Horses
    • Immunodiffusion / veterinary
    • Leukocyte Count / veterinary
    • Prealbumin / analysis
    • Serum Albumin / analysis

    References

    This article includes 14 references
    1. Breeze EG, Nicholls JM, Veitch J, Seltnem GE, Mc Pherson EA, Lawson GKH. Serum antitrypsin activity in horses with chronic pulmonary disease. Vet. Rec. 1977;101:146–149.
      doi: 10.1136/vr.101.7.130google scholar: lookup
    2. Braend M. Genetics of horse acidic prealbumins.. Genetics 1970 Jul;65(3):495-503.
      doi: 10.1093/genetics/65.3.495pmc: PMC1212461pubmed: 5519647google scholar: lookup
    3. Corbella E. First results of quantitative protease-inhibitors evaluation in equine pathology. Atti Soc. Ital. Sci. vet. 1975;29:315–318.
    4. Dimopoullos GT. Plasma proteins. In Clinical Biochemistry of Domestic Animals. 2nd Ed., J. J. Kaneko & C.. E. Cornelius, eds. Acad. Press, New York and London 1970.
    5. Ek N. Studies of electrophoresis on cellulose acetate membrane of serum proteins from normal horses, sheep and pigs.. Acta Vet Scand 1970;11(2):295-304.
      doi: 10.1186/BF03547989pmc: PMC8561507pubmed: 5449104google scholar: lookup
    6. Ek N, Braend M. Quantitative comparisons of acidic prealbumin (PR) phenotypes in horses.. Acta Vet Scand 1980;21(3):380-8.
      doi: 10.1186/BF03546870pmc: PMC8317704pubmed: 7446321google scholar: lookup
    7. Ganrot PO, Laurell CB, Eriksson S. Obstructive lung disease and trypsin inhibitors in alpha-1-antitrypsin deficiency.. Scand J Clin Lab Invest 1967;19(3):205-8.
      doi: 10.3109/00365516709090627pubmed: 6048625google scholar: lookup
    8. Harris CC, Primack A, Cohen MH. Elevated alpha1-Antitrypsin serum levels in lung cancer patients.. Cancer 1974 Aug;34(2):280-1.
      pubmed: 4211977doi: 10.1002/1097-0142(197408)34:2<280::aid-cncr2820340210>3.0.co;2-4google scholar: lookup
    9. Kueppers F. Genetically determined differences in the response of alpha-antitrypsin levels in human serum to typhoid vaccine.. Humangenetik 1968;6(3):207-14.
      doi: 10.1007/BF00291864pubmed: 5709080google scholar: lookup
    10. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion.. Immunochemistry 1965 Sep;2(3):235-54.
      doi: 10.1016/0019-2791(65)90004-2pubmed: 4956917google scholar: lookup
    11. Ohlsson K. Neutral leucocyte proteases and elastase inhibited by plasma alpha 1 -antitrypsin.. Scand J Clin Lab Invest 1971 Nov;28(3):251-3.
      doi: 10.3109/00365517109095696pubmed: 4109213google scholar: lookup
    12. Schalm OW. Veterinary Hematology. Lea & Febiger, Philadelphia 1967.
    13. Snedecor GW, Cochran WG. Statistical Methods. Iowa State Univ. Press, Ames, Iowa, USA 1967.
    14. Thorèn-Tolling K. Serum protein variations with pathologic conditions by horses and dogs. Svensk Vet.-Tidn. 1977, 20, 917–927.

    Citations

    This article has been cited 1 times.
    1. Ek N. Concentration of serum transferrin in sick horses and its relationship to serum albumin content.. Acta Vet Scand 1981;22(2):260-71.
      doi: 10.1186/BF03547515pubmed: 7304366google scholar: lookup
    Subscribe to our newsletter
    Join 99,359 horse owners like you who receive our email updates on horse health and nutrition.