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Home / Equine Research Bank / Invest Ophthalmol Vis Sci / Congenital stationary night blindness: an animal model.
Investigative ophthalmology & visual science1978; 17(8); 788-795;

Congenital stationary night blindness: an animal model.

Abstract: Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave implict time. The dark-adapted ERG's consisted of a simple negative potential; the scotopic b-wave was nonrecordable. However, a normal c-wave was present in the dark-adapted response. Histologic studies demonstrated no structural abnormalities that could explain the functional defect.
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Publication Date: 1978-08-01 PubMed ID: 308060
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  • Journal Article
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates night blindness in horses, using Appaloosa horses with myctalopia as a model. It was found that their photopic and scotopic abnormalities were similar to those seen in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type, yet no structural abnormalities were found that could explain the functional defect.

Understanding Night Blindness in Horses

  • The researchers focused on Electroretinographic (ERG) studies of Appaloosa horses afflicted with myctalopia, a condition that impairs night vision, popularly known as night blindness.
  • Through ERG, the researchers studied the horse’s response to light, investigating both photopic (light adapted) and scotopic (dark adapted) conditions.
  • The study focused on two types of waves in the Electroretinography: the b-wave, which evaluates the functionality of the inner retina, and the c-wave, which assesses the integrity of the outer retina.

Comparison to Human Night Blindness

  • Interestingly, the studies revealed photopic and scotopic abnormalities in these horses similar to those found in humans suffering from a specific type of congenital stationary night blindness (CSNB) – the Schubert-Bornschein type.
  • In both humans and these horses, the phototopic abnormalities manifest as reduced b-wave amplitudes and slower than normal b-wave implicit time, implicating the diminished functionality of the inner retina.
  • Similarly, in dark-adapted conditions, the scotopic b-wave was nonrecordable, further showcasing the disrupted retinal function in the presence of night blindness.

Notable Findings and Limitations

  • However, a study found that a normal c-wave was present in the dark-adapted response, suggesting that the outer retina’s integrity is maintained in the face of night blindness.
  • This was surprising as the c-wave generally declines in retinal degenerative conditions, but in this case it was preserved despite the vision defect.
  • Moreover, histologic studies, which involve the study of the microscopic structure of tissues, found no structural abnormalities that could explain the functional defect, suggesting that the disturbances are likely arising at a functional or physiological level rather than a gross structural one.

Cite This Article

APA
Witzel DA, Smith EL, Wilson RD, Aguirre GD. (1978). Congenital stationary night blindness: an animal model. Invest Ophthalmol Vis Sci, 17(8), 788-795.

Publication

Investigative ophthalmology & visual science
ISSN: 0146-0404
NlmUniqueID: 7703701
Country: United States
Language: English
Volume: 17
Issue: 8
Pages: 788-795

Researcher Affiliations

Witzel, D A
    Smith, E L
      Wilson, R D
        Aguirre, G D

          MeSH Terms

          • Adaptation, Physiological
          • Animals
          • Dark Adaptation
          • Disease Models, Animal
          • Electroretinography
          • Female
          • Horse Diseases / congenital
          • Horses
          • Light
          • Male
          • Night Blindness / congenital
          • Night Blindness / veterinary
          • Retina / pathology
          • Retina / physiopathology
          • Retina / ultrastructure

          Citations

          This article has been cited 21 times.
          1. Petersen-Jones SM, Pasmanter N, Occelli LM, Gervais KJ, Mowat FM, Querubin J, Winkler PA. An unusual inherited electroretinogram feature with an exaggerated negative component in dogs. Vet Ophthalmol 2022 Sep;25(5):385-397.
            doi: 10.1111/vop.12998pubmed: 35713167google scholar: lookup
          2. Varin J, Bouzidi N, Gauvain G, Joffrois C, Desrosiers M, Robert C, De Sousa Dias MM, Neuillé M, Michiels C, Nassisi M, Sahel JA, Picaud S, Audo I, Dalkara D, Zeitz C. Substantial restoration of night vision in adult mice with congenital stationary night blindness. Mol Ther Methods Clin Dev 2021 Sep 10;22:15-25.
            doi: 10.1016/j.omtm.2021.05.008pubmed: 34401402google scholar: lookup
          3. Winkler PA, Occelli LM, Petersen-Jones SM. Large Animal Models of Inherited Retinal Degenerations: A Review. Cells 2020 Apr 3;9(4).
            doi: 10.3390/cells9040882pubmed: 32260251google scholar: lookup
          4. Das RG, Becker D, Jagannathan V, Goldstein O, Santana E, Carlin K, Sudharsan R, Leeb T, Nishizawa Y, Kondo M, Aguirre GD, Miyadera K. Genome-wide association study and whole-genome sequencing identify a deletion in LRIT3 associated with canine congenital stationary night blindness. Sci Rep 2019 Oct 2;9(1):14166.
            doi: 10.1038/s41598-019-50573-7pubmed: 31578364google scholar: lookup
          5. Miraldi Utz V, Pfeifer W, Longmuir SQ, Olson RJ, Wang K, Drack AV. Presentation of TRPM1-Associated Congenital Stationary Night Blindness in Children. JAMA Ophthalmol 2018 Apr 1;136(4):389-398.
            doi: 10.1001/jamaophthalmol.2018.0185pubmed: 29522070google scholar: lookup
          6. Kondo M, Das G, Imai R, Santana E, Nakashita T, Imawaka M, Ueda K, Ohtsuka H, Sakai K, Aihara T, Kato K, Sugimoto M, Ueno S, Nishizawa Y, Aguirre GD, Miyadera K. A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. PLoS One 2015;10(9):e0137072.
            doi: 10.1371/journal.pone.0137072pubmed: 26368928google scholar: lookup
          7. Bellone RR, Holl H, Setaluri V, Devi S, Maddodi N, Archer S, Sandmeyer L, Ludwig A, Foerster D, Pruvost M, Reissmann M, Bortfeldt R, Adelson DL, Lim SL, Nelson J, Haase B, Engensteiner M, Leeb T, Forsyth G, Mienaltowski MJ, Mahadevan P, Hofreiter M, Paijmans JL, Gonzalez-Fortes G, Grahn B, Brooks SA. Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse. PLoS One 2013;8(10):e78280.
            doi: 10.1371/journal.pone.0078280pubmed: 24167615google scholar: lookup
          8. Peachey NS, Pearring JN, Bojang P Jr, Hirschtritt ME, Sturgill-Short G, Ray TA, Furukawa T, Koike C, Goldberg AF, Shen Y, McCall MA, Nawy S, Nishina PM, Gregg RG. Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. J Neurophysiol 2012 Nov;108(9):2442-51.
            doi: 10.1152/jn.00137.2012pubmed: 22896717google scholar: lookup
          9. Brosnahan MM, Brooks SA, Antczak DF. Equine clinical genomics: A clinician's primer. Equine Vet J 2010 Oct;42(7):658-70.
            doi: 10.1111/j.2042-3306.2010.00166.xpubmed: 20840582google scholar: lookup
          10. Webb AA, Cullen CL. Coat color and coat color pattern-related neurologic and neuro-ophthalmic diseases. Can Vet J 2010 Jun;51(6):653-7.
            pubmed: 20808581
          11. Audo I, Kohl S, Leroy BP, Munier FL, Guillonneau X, Mohand-Saïd S, Bujakowska K, Nandrot EF, Lorenz B, Preising M, Kellner U, Renner AB, Bernd A, Antonio A, Moskova-Doumanova V, Lancelot ME, Poloschek CM, Drumare I, Defoort-Dhellemmes S, Wissinger B, Léveillard T, Hamel CP, Schorderet DF, De Baere E, Berger W, Jacobson SG, Zrenner E, Sahel JA, Bhattacharya SS, Zeitz C. TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 2009 Nov;85(5):720-9.
            doi: 10.1016/j.ajhg.2009.10.013pubmed: 19896113google scholar: lookup
          12. Shen Y, Heimel JA, Kamermans M, Peachey NS, Gregg RG, Nawy S. A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci 2009 May 13;29(19):6088-93.
            doi: 10.1523/JNEUROSCI.0132-09.2009pubmed: 19439586google scholar: lookup
          13. Bellone RR, Brooks SA, Sandmeyer L, Murphy BA, Forsyth G, Archer S, Bailey E, Grahn B. Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics 2008 Aug;179(4):1861-70.
            doi: 10.1534/genetics.108.088807pubmed: 18660533google scholar: lookup
          14. Sandmeyer LS, Grahn BH, Breaux CB. Diagnostic ophthalmology. Congenital stationary night blindness (CSNB). Can Vet J 2006 Nov;47(11):1131, 1133.
            pubmed: 17147148
          15. Rigaudière F, Roux C, Lachapelle P, Rosolen SG, Bitoun P, Gay-Duval A, Le Gargasson JF. ERGs in female carriers of incomplete congenital stationary night blindness (I-CSNB). A family report. Doc Ophthalmol 2003 Sep;107(2):203-12.
            doi: 10.1023/a:1026212318245pubmed: 14661912google scholar: lookup
          16. Racine J, Behn D, Simard E, Lachapelle P. Spontaneous occurrence of a potentially night blinding disorder in guinea pigs. Doc Ophthalmol 2003 Jul;107(1):59-69.
            doi: 10.1023/a:1024435911882pubmed: 12906123google scholar: lookup
          17. Ofri R. Clinical electrophysiology in veterinary ophthalmology--the past, present and future. Doc Ophthalmol 2002 Jan;104(1):5-16.
            doi: 10.1023/a:1014463514302pubmed: 11949808google scholar: lookup
          18. Alexander KR, Fishman GA. Rod-cone interaction in flicker perimetry: evidence for a distal retinal locus. Doc Ophthalmol 1985 Aug 15;60(1):3-36.
            doi: 10.1007/BF00164567pubmed: 3930192google scholar: lookup
          19. Siegel IM, Greenstein VC, Seiple WH, Carr RE. Cone function in congenital nyctalopia. Doc Ophthalmol 1987 Mar;65(3):307-18.
            doi: 10.1007/BF00149937pubmed: 3500024google scholar: lookup
          20. Watanabe I, Taniguchi Y, Morioka K, Kato M. Congenital stationary night blindness with myopia: a clinico-pathologic study. Doc Ophthalmol 1986 Jun 16;63(1):55-62.
            doi: 10.1007/BF00153012pubmed: 3488187google scholar: lookup
          21. Narfström K, Wrigstad A, Nilsson SE. The Briard dog: a new animal model of congenital stationary night blindness. Br J Ophthalmol 1989 Sep;73(9):750-6.
            doi: 10.1136/bjo.73.9.750pubmed: 2804031google scholar: lookup
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