Control of FSH, follicular development and estrus synchronization in the mare with steroid-free follicular fluid.
Abstract: Twenty-two pony mares were used in a project designed to determine the effectiveness of different treatments in controlling FSH, follicular development and synchronization of estrus and ovulation. Mares in Group 1 (n=8) received daily oral altrenogest (0.044 mg/kg); those in Group 2 (n=7) received daily altrenogest (0.044 g/kg) and, during the last 4 days of treatment they received steroid-free follicular fluid, (15 cc) intravenously (I.V.) two times a day; Mares in Group 3 (n=7) received daily intramuscular (I.M.) injections of progesterone (80 mg) and estradiol valerate (7 mg). All treatments lasted for 10 days, at the end of which prostaglandin (PgF(2)alpha, 10 mg) was administered. Sexual behavior, follicular development and FSH concentrations were monitor daily. Concentrations of FSH in Group 2 mares, were not significantly different (P>0.05) from those of Group 1 until the mares in Group 2 were treated with follicular fluid (P<0.05). Concentrations of FSH in Group 3 mares, were significantly lower than those of Groups 1 and 2 (P0.05). Steroid-free follicular fluid appears to induce atresia in larger follicles (>11 mm), and the initiation of new follicular wave. The combination of progesterone and estradiol valerate appears to delay follicular growth and not to induce atresia, since larger follicles (>11 mm) continued to grow after treatment. Both treatments (groups 2 and 3) resulted in ovulations within 5 days period. The treatment in Group 1 did not have any effect on FSH or follicular development and ovulations were dispersed through a 9-day period. We concluded that steroid-free follicular fluid offers a new possibility to synchronize ovulation in the mare by controlling FSH and follicular development.
Publication Date: 1992-04-01 PubMed ID: 16727082DOI: 10.1016/0093-691x(92)90044-rGoogle Scholar: Lookup
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Summary
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The study investigates various treatments to control follicular stimulation hormone (FSH), follicular development, and synchronization of estrus and ovulation in pony mares, with findings leaning towards steroid-free follicular fluid as a new possibility to synchronize ovulation by controlling FSH and follicular development.
Objective and Methodology
- The objective was to determine the effectiveness of different treatments in controlling FSH, follicular development, and the synchronization of estrus and ovulation in pony mares.
- A total of twenty-two pony mares were divided into three groups, each receiving different types of treatment.
- Group 1 (8 mares) received daily oral altrenogest, Group 2 (7 mares) received daily altrenogest and steroid-free follicular fluid during the last 4 days of treatment twice a day, and Group 3 (7 mares) was given daily intramuscular injections of progesterone and estradiol valerate.
- All treatments lasted for 10 days and a dose of prostaglandin was administered at the end of the treatments. The sexual behavior, follicular development, and FSH concentrations of the mares were closely monitored daily.
Findings
- After the initial 10 days of treatment, the concentration of FSH in Group 2 and Group 3 mares was significantly lower than in Group 1 until Group 2 mares were treated with follicular fluid. However, when Group 2 mares were introduced to the steroid-free follicular fluid, no significant difference was observed in FSH concentration between Group 2 and 3.
- The steroid-free follicular fluid seemed to induce atresia in larger follicles (greater than 11 mm), and initiate a new follicular wave, whereas the combination of progesterone and estradiol valerate seemed to delay follicular growth without inducing atresia, as larger follicles continued to grow after treatment.
- Both treatments (Group 2 and Group 3) resulted in ovulations within a 5-day period. Meanwhile, the treatment in Group 1 did not have any perceivable effect on FSH or follicular development and ovulations were dispersed through a 9-day period.
Conclusion
- The study concluded that steroid-free follicular fluid offers a promising potential to synchronize the ovulation in pony mares by controlling the follicular stimulatory hormone and the development of the follicle.
- This research opens doors to understanding the effect of hormonal modification and control on horse reproduction and could be seminal in advancing targeted veterinary and breeding techniques.
Cite This Article
APA
Plata-Madrid H, Loch WE, Youngquist RS, Thompson DL, Bennett-Wimbush KG, Wilkerson C, Bouchard G, Smith MF, Braun WF, Aveiro JJ.
(1992).
Control of FSH, follicular development and estrus synchronization in the mare with steroid-free follicular fluid.
Theriogenology, 37(4), 817-838.
https://doi.org/10.1016/0093-691x(92)90044-r Publication
Researcher Affiliations
- Department of Veterinary Medicine and Surgery University of Missouri, Columbia, MO 65211 USA.
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