Copper metabolism and requirement in mature ponies.
Abstract: The effects of copper intake on stable copper and 64Cu metabolism and on the excretory pathways of absorbed copper were examined in ponies. Bile and feces collected from two bile duct-cannulated ponies following an intravenous dose of 64Cu showed that bile was the main route of endogenous copper excretion. Stable copper and 64Cu metabolism were examined in three intact ponies fed dietary copper to provide 5.6, 16.6 and 25.7 mg Cu/100 kg body weight/day. The amount of copper excreted in urine was not influenced by dietary treatment. Stable copper absorption and 64Cu retention significantly increased when ponies were fed the low copper ration. A direct linear relationship was observed between 64Cu excretion in feces and copper intake. Isotope dilution methods and regression analyses of data from balance studies were used to estimate an obligatory copper loss in ponies of approximately 3.5 mg Cu/100 kg body weight per day. The estimated dietary copper requirement for maintenance of mature ponies was 3.5 ppm.
Publication Date: 1981-01-01 PubMed ID: 7452377DOI: 10.1093/jn/111.1.87Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study assesses the effects of copper intake on copper metabolism and excretion in mature ponies. The research found that copper absorption and retention are impacted significantly by dietary modification and that the principal pathway of copper excretion is through bile. Based on the findings, the researchers suggest an estimated dietary copper requirement of 3.5 ppm for the maintenance of mature ponies.
Research Methodology
- The study explored the impacts of copper intake on stable copper and 64Cu metabolism and the excretion pathways of absorbed copper in ponies.
- Bile and feces were collected from two ponies with cannulated bile ducts after being given an intravenous dose of 64Cu.
- Three different intact ponies were fed dietary copper to provide 5.6, 16.6 and 25.7 mg Cu/100 kg body weight/day to examine stable copper and 64Cu metabolism.
- Isotope dilution methods and regression analyses were used to analyze data from balance studies.
Findings
- The researchers found no influence on the amount of copper excreted in urine by the dietary treatment.
- However, a significant increase was observed in stable copper absorption and 64Cu retention when the ponies were fed a low copper ration.
- Bile was identified as the primary route of endogenous copper excretion.
- A direct linear relationship was discovered between 64Cu excretion in feces and copper intake.
Conclusion
- Based on this research, an obligatory copper loss of around 3.5 mg Cu/100 kg body weight per day was estimated in ponies.
- Therefore, the scientists concluded that the estimated dietary copper requirement for the maintenance of mature ponies is 3.5 ppm.
Cite This Article
APA
Cymbaluk NF, Schryver HF, Hintz HF.
(1981).
Copper metabolism and requirement in mature ponies.
J Nutr, 111(1), 87-95.
https://doi.org/10.1093/jn/111.1.87 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Bile / metabolism
- Bile Ducts
- Catheterization
- Ceruloplasmin / metabolism
- Copper / administration & dosage
- Copper / metabolism
- Dose-Response Relationship, Drug
- Feces / analysis
- Horses / metabolism
- Nutritional Requirements
Citations
This article has been cited 2 times.- Rueda-Carrillo G, Rosiles-Martínez R, Corona-Gochi L, Hernández-García A, López-Navarro G, Trigo-Tavera F. Comparison of the Mineral Profile of Two Types of Horse Diet, Silage and Commercial Concentrate, and Their Impacts on Hoof Tensile Strength. Animals (Basel) 2022 Nov 18;12(22).
- Hill GM, Shannon MC. Copper and Zinc Nutritional Issues for Agricultural Animal Production. Biol Trace Elem Res 2019 Mar;188(1):148-159.
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