Herpetic corneal epithelial disease.
Abstract: The clinical differentiation of corneal epithelial lesions due to herpes simplex or herpes zoster may be confusing. Practical clinical tests, including the use of topical ocular stains, are useful to differentiate corneal epithelial lesions caused by these two viruses. Two distinctive types of zoster corneal epithelial disease may be seen; an early dendritic form, and a delayed form characterized by corneal mucus plaques that may take a dendriform pattern. These plaques are composed of mucus that is adherent to swollen, degenerating epithelial cells. The clinical differentiation between these two viruses is essential since topically applied corticosteroids are contraindicated in epithelial herpes simplex and often are indicated in the management of epithelial herpes zoster.
Publication Date: 1976-11-01 PubMed ID: 62568DOI: 10.1001/archopht.1976.03910040609004Google Scholar: Lookup
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- Journal Article
Summary
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This research article discusses various diseases that mainly affect the corneal epithelium, separating them from corneal stromal diseases. It includes an array of epithelial conditions, uninfected superficial ulcerations, corneal neoplasia, eosinophilic keratitis, and an uncommon form of epithelial infection known as fungal plaque. The paper highlights the challenges in diagnosing these conditions and discusses contemporary therapies and surgical strategies.
Corneal Epithelial Diseases
- The primary focus of this research paper is on conditions affecting the corneal epithelium – the outermost layer of the eye’s cornea. These diseases are distinct from corneal stromal diseases, which affect a different layer of the cornea and are discussed separately.
- These conditions encompass a range of subtle epithelial diseases that can be collectively termed epitheliopathies, emphasizing their specificity to the epithelial tissue of the cornea. The exact nature and causes of these epitheliopathies vary, posing a unique challenge for medical professionals.
Uninfected Superficial Ulcerations and Other Conditions
- Additionally, the article delves into various other conditions impacting the cornea’s epithelial layer, such as uninfected superficial ulcerations. These are described as shallow open sores on the cornea that are not accompanied by any infection.
- The research discusses corneal neoplasia, a condition marked by an abnormal growth in the cornea, and eosinophilic keratitis, an inflammation of the cornea caused by an increase in eosinophils, a type of white blood cell.
Fungal Plaque and Diagnostic Challenges
- The researchers also ponder upon an unusual form of epithelial infection called a fungal plaque. It is described as somewhat chronic and is less common than corneal ulcers.
- One significant aspect highlighted by the study is the challenge in diagnosing these diverse conditions affecting the cornea’s epithelial layer due to their unique presentations and pathologies.
New Therapies and Surgical Strategies
- The article concludes by addressing newer therapeutic methods for managing these conditions, signifying a departure from more traditional means of treatment.
- Novel surgical strategies have been discussed, pushing forward the understanding and the potential for improved patient care in managing corneal epithelial diseases.
Cite This Article
APA
Marsh RJ, Fraunfelder FT, McGill JI.
(1976).
Herpetic corneal epithelial disease.
Arch Ophthalmol, 94(11), 1899-1902.
https://doi.org/10.1001/archopht.1976.03910040609004 Publication
Researcher Affiliations
MeSH Terms
- Adrenal Cortex Hormones / therapeutic use
- Alcian Blue
- Cornea / pathology
- Diagnosis, Differential
- Fluoresceins
- Herpes Zoster Ophthalmicus / diagnosis
- Herpes Zoster Ophthalmicus / drug therapy
- Herpes Zoster Ophthalmicus / pathology
- Humans
- Keratitis, Dendritic / diagnosis
- Keratitis, Dendritic / pathology
- Rose Bengal
- Staining and Labeling
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