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Archives of ophthalmology (Chicago, Ill. : 1960)1976; 94(11); 1899-1902; doi: 10.1001/archopht.1976.03910040609004

Herpetic corneal epithelial disease.

Abstract: The clinical differentiation of corneal epithelial lesions due to herpes simplex or herpes zoster may be confusing. Practical clinical tests, including the use of topical ocular stains, are useful to differentiate corneal epithelial lesions caused by these two viruses. Two distinctive types of zoster corneal epithelial disease may be seen; an early dendritic form, and a delayed form characterized by corneal mucus plaques that may take a dendriform pattern. These plaques are composed of mucus that is adherent to swollen, degenerating epithelial cells. The clinical differentiation between these two viruses is essential since topically applied corticosteroids are contraindicated in epithelial herpes simplex and often are indicated in the management of epithelial herpes zoster.
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Publication Date: 1976-11-01 PubMed ID: 62568DOI: 10.1001/archopht.1976.03910040609004Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses various diseases that mainly affect the corneal epithelium, separating them from corneal stromal diseases. It includes an array of epithelial conditions, uninfected superficial ulcerations, corneal neoplasia, eosinophilic keratitis, and an uncommon form of epithelial infection known as fungal plaque. The paper highlights the challenges in diagnosing these conditions and discusses contemporary therapies and surgical strategies.

Corneal Epithelial Diseases

  • The primary focus of this research paper is on conditions affecting the corneal epithelium – the outermost layer of the eye’s cornea. These diseases are distinct from corneal stromal diseases, which affect a different layer of the cornea and are discussed separately.
  • These conditions encompass a range of subtle epithelial diseases that can be collectively termed epitheliopathies, emphasizing their specificity to the epithelial tissue of the cornea. The exact nature and causes of these epitheliopathies vary, posing a unique challenge for medical professionals.

Uninfected Superficial Ulcerations and Other Conditions

  • Additionally, the article delves into various other conditions impacting the cornea’s epithelial layer, such as uninfected superficial ulcerations. These are described as shallow open sores on the cornea that are not accompanied by any infection.
  • The research discusses corneal neoplasia, a condition marked by an abnormal growth in the cornea, and eosinophilic keratitis, an inflammation of the cornea caused by an increase in eosinophils, a type of white blood cell.

Fungal Plaque and Diagnostic Challenges

  • The researchers also ponder upon an unusual form of epithelial infection called a fungal plaque. It is described as somewhat chronic and is less common than corneal ulcers.
  • One significant aspect highlighted by the study is the challenge in diagnosing these diverse conditions affecting the cornea’s epithelial layer due to their unique presentations and pathologies.

New Therapies and Surgical Strategies

  • The article concludes by addressing newer therapeutic methods for managing these conditions, signifying a departure from more traditional means of treatment.
  • Novel surgical strategies have been discussed, pushing forward the understanding and the potential for improved patient care in managing corneal epithelial diseases.

Cite This Article

APA
Marsh RJ, Fraunfelder FT, McGill JI. (1976). Herpetic corneal epithelial disease. Arch Ophthalmol, 94(11), 1899-1902. https://doi.org/10.1001/archopht.1976.03910040609004

Publication

Archives of ophthalmology (Chicago, Ill. : 1960)
ISSN: 0003-9950
NlmUniqueID: 7706534
Country: United States
Language: English
Volume: 94
Issue: 11
Pages: 1899-1902

Researcher Affiliations

Marsh, R J
    Fraunfelder, F T
      McGill, J I

        MeSH Terms

        • Adrenal Cortex Hormones / therapeutic use
        • Alcian Blue
        • Cornea / pathology
        • Diagnosis, Differential
        • Fluoresceins
        • Herpes Zoster Ophthalmicus / diagnosis
        • Herpes Zoster Ophthalmicus / drug therapy
        • Herpes Zoster Ophthalmicus / pathology
        • Humans
        • Keratitis, Dendritic / diagnosis
        • Keratitis, Dendritic / pathology
        • Rose Bengal
        • Staining and Labeling

        Citations

        This article has been cited 15 times.
        1. Daryabari SH, Mosavi SA, Moghtaderi M. Cytomegalovirus keratitis in acute myeloblastic leukemia. Oman J Ophthalmol 2023 May-Aug;16(2):370-372.
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          doi: 10.1038/cddis.2016.473pubmed: 28151483google scholar: lookup
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          doi: 10.1186/s40164-016-0054-1pubmed: 27508107google scholar: lookup
        6. Maker AV, Prabhakar B, Pardiwala K. The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses. J Clin Cell Immunol 2015 Aug;6(4).
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        7. Thompson JF, Agarwala SS, Smithers BM, Ross MI, Scoggins CR, Coventry BJ, Neuhaus SJ, Minor DR, Singer JM, Wachter EA. Phase 2 Study of Intralesional PV-10 in Refractory Metastatic Melanoma. Ann Surg Oncol 2015 Jul;22(7):2135-42.
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        8. Sy A, McLeod SD, Cohen EJ, Margolis TP, Mannis MJ, Lietman TM, Acharya NR. Practice patterns and opinions in the management of recurrent or chronic herpes zoster ophthalmicus. Cornea 2012 Jul;31(7):786-90.
          doi: 10.1097/ICO.0b013e31823cbe6apubmed: 22269677google scholar: lookup
        9. Hu AY, Strauss EC, Holland GN, Chan MF, Yu F, Margolis TP. Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol 2010 Feb;149(2):214-220.e3.
          doi: 10.1016/j.ajo.2009.08.030pubmed: 19909942google scholar: lookup
        10. Bielory L. Ocular allergy treatments. Clin Rev Allergy Immunol 2001 Apr;20(2):201-13.
          doi: 10.1385/CRIAI:20:2:201pubmed: 11349610google scholar: lookup
        11. McGill J. Topical acyclovir in herpes zoster ocular involvement. Br J Ophthalmol 1981 Aug;65(8):542-5.
          doi: 10.1136/bjo.65.8.542pubmed: 7028083google scholar: lookup
        12. McGill J, Chapman C. A comparison of topical acyclovir with steroids in the treatment of herpes zoster keratouveitis. Br J Ophthalmol 1983 Nov;67(11):746-50.
          doi: 10.1136/bjo.67.11.746pubmed: 6357273google scholar: lookup
        13. McGill J. The enigma of herpes stromal disease. Br J Ophthalmol 1987 Feb;71(2):118-25.
          doi: 10.1136/bjo.71.2.118pubmed: 3548807google scholar: lookup
        14. Marsh RJ, Cooper M. Ophthalmic zoster: mucous plaque keratitis. Br J Ophthalmol 1987 Oct;71(10):725-8.
          doi: 10.1136/bjo.71.10.725pubmed: 3499932google scholar: lookup
        15. Mondino BJ, Farley MK, Aizuss DH. Sectorial corneal infiltrates and pannus in herpes zoster ophthalmicus. Graefes Arch Clin Exp Ophthalmol 1986;224(3):313-6.
          doi: 10.1007/BF02143077pubmed: 2423418google scholar: lookup
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