Correction: The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models.
Abstract: Correction for 'The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models' by Johannes Heidenberger et al., Lab Chip, 2025, 25, 2256-2269, https://doi.org/10.1039/d4lc01078g.
Publication Date: 2025-05-28 PubMed ID: 40341852DOI: 10.1039/d5lc90048dGoogle Scholar: Lookup
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- Published Erratum
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article investigates the impact of cyclic fluid perfusion on the inflammatory state of osteoarthritis in horses, utilizing joint-on-a-chip models for the study.
Objective of the Research
This article focuses on a study by Johannes Heidenberger, which aims to understand the role and impact of cyclic fluid perfusion on the proinflammatory tissue environment associated with osteoarthritis. The study employs equine joint on-a-chip models, a relevant platform used to study joint diseases like osteoarthritis.
Role of Cyclic Fluid Perfusion
- Cyclic fluid perfusion describes the cycling or rhythmic flow of fluids within the body like blood flow within vessels, or synovial fluid within joints. This is a crucial part of the body’s homeostatic mechanisms.
- In the context of osteoarthritis, an inflammatory disease, the role of cyclic fluid perfusion is critical as it can either exacerbate or alleviate the inflammation. It is plausible that changes in fluid perfusion rates could influence the inflammatory process, hence the interest in studying its effects.
Using Equine Joint-on-a-Chip Models
- A joint-on-a-chip is a type of organ-on-a-chip, a multi-channel three-dimensional microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems.
- The chip models have been tuned to simulate equine (horse) joints for this study. Equine joints are an excellent choice for studying osteoarthritis as horses are one of the animal species that naturally suffer from this disease, hence their response could closely mirror the human condition.
Significance of the Correction
- Research paper corrections are typical and important aspects of scientific studies that ensure the accuracy and validity of the findings reported.
- This specific correction for the paper ‘The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models’ is necessary in order to maintain the integrity of this study.
Cite This Article
APA
Heidenberger J, Reihs EI, Strauss J, Frauenlob M, Gültekin S, Gerner I, Toegel S, Ertl P, Windhager R, Jenner F, Rothbauer M.
(2025).
Correction: The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models.
Lab Chip, 25(11), 2795-2796.
https://doi.org/10.1039/d5lc90048d Publication
Researcher Affiliations
- Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. mario.rothbauer@muv.ac.at.
- Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. mario.rothbauer@muv.ac.at.
- Faculty of Technical Chemistry, Technische Universität Wien, Getreidemarkt 9/163, 1060 Vienna, Austria. mario.rothbauer@tuwien.ac.at.
- Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. mario.rothbauer@muv.ac.at.
- Faculty of Technical Chemistry, Technische Universität Wien, Getreidemarkt 9/163, 1060 Vienna, Austria. mario.rothbauer@tuwien.ac.at.
- Faculty of Technical Chemistry, Technische Universität Wien, Getreidemarkt 9/163, 1060 Vienna, Austria. mario.rothbauer@tuwien.ac.at.
- Department for Small Animals and Horses, Centre for Equine Health and Research, Equine Surgery Unit, Veterinary Regenerative Medicine Laboratory, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
- Department for Small Animals and Horses, Centre for Equine Health and Research, Equine Surgery Unit, Veterinary Regenerative Medicine Laboratory, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
- Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. mario.rothbauer@muv.ac.at.
- Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria.
- Faculty of Technical Chemistry, Technische Universität Wien, Getreidemarkt 9/163, 1060 Vienna, Austria. mario.rothbauer@tuwien.ac.at.
- Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. mario.rothbauer@muv.ac.at.
- Department for Small Animals and Horses, Centre for Equine Health and Research, Equine Surgery Unit, Veterinary Regenerative Medicine Laboratory, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
- Department of Orthopedics and Trauma Surgery, Karl Chiari Lab for Orthopaedic Biology, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria. mario.rothbauer@muv.ac.at.
- Faculty of Technical Chemistry, Technische Universität Wien, Getreidemarkt 9/163, 1060 Vienna, Austria. mario.rothbauer@tuwien.ac.at.
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