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Home / Equine Research Bank / J Vet Intern Med / Correlation between l-lactate and glucose concentrations and...
Journal of veterinary internal medicine2019; 33(5); 2267-2271; doi: 10.1111/jvim.15587

Correlation between l-lactate and glucose concentrations and body condition score in healthy horses and ponies.

Abstract: Blood l-lactate and glucose concentrations were higher in ponies with gastrointestinal disease than in horses, possibly because of differences in body condition (BC). Objective: To investigate whether l-lactate and glucose concentrations correlate with BC and differ between healthy horses and ponies. Methods: Systemically healthy client-owned ponies (n = 101) and horses (n = 51). Methods: Prospective observational study. Breed, weight, height, and subjective and objective measures of BC were recorded and l-lactate and glucose concentrations were measured. Correlations between l-lactate and glucose concentrations and BC were established. The association between l-lactate concentrations, equid type (pony or horse), BC, age, and glucose concentrations was investigated using a multivariable model. Results: Weak but significant (P = .001) negative correlations were detected between l-lactate concentration and average BC score (r = -0.29), heart girth:height ratio (r = -0.27), and age (r = -0.27). Glucose concentrations were significantly (P < .001) positively correlated with neck length:heart girth ratio (r = 0.37) and heart girth:height ratio (r = 0.31). l-lactate and glucose concentrations were weakly correlated (r = 0.15; P = .04). In the final multivariable model, age (-0.02 ± 0.006; P = .001) and heart girth:height ratio (-1.74 ± 0.53; P = .001) were significantly associated with the natural logarithm of l-lactate concentration (Lnl-Lactate). This represents a 2% decrease in l-lactate concentration per year increase in age and 10% decrease in l-lactate concentration per 0.06 unit increase in heart girth:height ratio. Conclusions: In healthy horses and ponies, age and BC significantly influence l-lactate concentrations.
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2019-08-07 PubMed ID: 31390098PubMed Central: PMC6766520DOI: 10.1111/jvim.15587Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

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The research study examines the relationship between l-lactate and glucose concentrations in the blood with body condition scores in healthy horses and ponies, indicating that both age and body condition have significant impacts on l-lactate concentrations.

Study Methodology

  • The study observed systemically healthy, client-owned ponies (101 in number) and horses (51 in number). This large sample helped ensure the accuracy and reliability of the results.
  • Various factors were recorded for each animal, including breed, weight, height, and both subjective and objective measurements of body condition. These variables were considered as they may have potential influences on l-lactate and glucose concentrations.
  • The researchers measured the l-lactate and glucose concentrations in the blood of the horses and ponies to determine any correlational relationship with measurement factors and body condition score.
  • A multivariable model was used to investigate the relationship between l-lactate concentrations, the species of equid (horse or pony), body condition, age, and glucose concentrations.

Results

  • The results showed weak yet significant correlations between various factors. l-lactate concentration was found to negatively correlate with body condition score, heart girth to height ratio, and age. This means as these values go up, l-lactate concentration tends to decrease and vice versa.
  • Glucose concentration was found to positively correlate with neck length to heart girth ratio and heart girth to height ratio. This suggests that as these ratios increase, the glucose concentration tends to increase as well.
  • A weak correlation was also observed between l-lactate and glucose concentrations.
  • In the final multivariable model, both age and the heart girth to height ratio were found to have a significantly associated with the natural logarithm of l-lactate concentration. This indicated a 2% decrease in l-lactate concentration per year increase in age and a 10% decrease in l-lactate concentration per 0.06 unit increase in heart girth to height ratio. These results further highlight the influence of both age and body condition on l-lactate concentration.

Conclusions

  • The study concludes that in healthy horses and ponies, there is a significant influence of age and body condition on l-lactate concentrations. This suggests that as the animals age and their body condition changes, it can intimately impact their blood l-lactate levels.

Cite This Article

APA
Dunkel B, Knowles EJ, Chang YM, Menzies-Gow NJ. (2019). Correlation between l-lactate and glucose concentrations and body condition score in healthy horses and ponies. J Vet Intern Med, 33(5), 2267-2271. https://doi.org/10.1111/jvim.15587

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 33
Issue: 5
Pages: 2267-2271

Researcher Affiliations

Dunkel, Bettina
  • Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.
Knowles, Edward J
  • Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.
Chang, Yu-Mei
  • Research Support Office, The Royal Veterinary College, North Mymms, United Kingdom.
Menzies-Gow, Nicola J
  • Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, United Kingdom.

MeSH Terms

  • Age Factors
  • Animals
  • Blood Glucose
  • Body Size
  • Body Weight
  • Female
  • Horses / blood
  • Horses / physiology
  • Lactic Acid / blood
  • Male
  • Prospective Studies

Conflict of Interest Statement

Authors declare no conflict of interest.

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Citations

This article has been cited 3 times.
  1. Yu Q, Guo M, Zeng W, Zeng M, Zhang X, Zhang Y, Zhang W, Jiang X, Yu B. Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis. Immun Inflamm Dis 2022 Mar;10(3):e581.
    doi: 10.1002/iid3.581pubmed: 34904398google scholar: lookup
  2. Dunkel B, Knowles EJ, Chang YM, Menzies-Gow NJ. Influence of endocrine disease on l-lactate concentrations in blood of ponies. J Vet Intern Med 2021 May;35(3):1582-1588.
    doi: 10.1111/jvim.16079pubmed: 34043845google scholar: lookup
  3. Witkowska-Piłaszewicz O, Cywińska A, Michlik-Połczyńska K, Czopowicz M, Strzelec K, Biazik A, Parzeniecka-Jaworska M, Crisman M, Witkowski L. Variations in haematological and biochemical parameters in healthy ponies. BMC Vet Res 2021 Jan 19;17(1):38.
    doi: 10.1186/s12917-020-02741-5pubmed: 33468115google scholar: lookup
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