Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study.
Abstract: Injuries penetrating synovial structures are common in equine practice and often result in septic synovitis. Significantly increased plasma levels of serum amyloid A (SAA) have been found in various infectious conditions in horses including wounds and septic arthritis. Plasma SAA levels were found to decrease rapidly once the infectious stimulus was eliminated. The purpose of the current study was to investigate the usefulness of serial measurements of plasma SAA as a monitoring tool for the response to treatment of horses presented with injuries penetrating synovial structures. In the current study plasma SAA concentrations were measured every 48 hours (h) during the course of treatment. Results: A total of 19 horses with a wound penetrating a synovial structure were included in the current study. Horses in Group 1 (n = 12) (injuries older than 24 h) only needed one surgical intervention. Patients in this group had significantly lower median plasma SAA levels (P = 0.001) between 48 h (median 776 mg/L) and 96 h (median 202 mg/L) after surgery. A significant decrease (P = 0.004) in plasma SAA levels was also observed between 96 h after surgery (median 270 mg/L) and 6 days (d) after surgery (median 3 mg/L). Four horses (Group 2) required more than one surgical intervention. In contrast to Group 1 patients in Group 2 had either very high initial plasma concentrations (3378 mg/L), an increase or persistently high concentrations of plasma SAA after the first surgery (median 2525 mg/L). A small group of patients (n = 3) (Group 3) were admitted less than 24 h after sustaining a wound. In this group low SAA values at admission (median 23 mg/L) and peak concentrations at 48 h after surgery (median 1016 mg/L) were observed followed by a decrease in plasma SAA concentration over time. Conclusions: A decrease in plasma SAA concentrations between two consecutive time points could be associated with positive response to treatment in the current study. Therefore, serial measurements of plasma SAA could potentially be used as an additional inexpensive, quick and easy tool for monitoring the treatment response in otherwise healthy horses presented with injuries penetrating synovial structures. However further studies will be necessary to ascertain its clinical utility.
Publication Date: 2017-05-22 PubMed ID: 28532514PubMed Central: PMC5441074DOI: 10.1186/s12917-017-1057-9Google Scholar: Lookup
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- Journal Article
- Observational Study
Summary
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This research aimed to evaluate the usefulness of measuring the concentration of serum amyloid A (SAA) in plasma as a method to monitor the treatment response in horses with injuries penetrating synovial structures. The study concluded that declines in plasma SAA concentrations could indicate positive treatment response, suggesting its potential as a rapid, affordable, and simple monitoring tool.
Objective of the Study
- The primary goal was to explore the potential utility of repeated measurements of plasma SAA as a monitoring tool for evaluating the treatment response in horses with injuries penetrating their synovial structures.
Methodology of the Study
- Researchers measured the plasma concentrations of SAA in 19 horses with injuries penetrating a synovial structure every 48 hours throughout the treatment course.
- The horses were grouped based on the time of injury prior to admission and the number of surgical interventions required. Group 1 consisted of horses with injuries 24 hours old, needing only one surgical intervention, Group 2 consisted of horses requiring more than one surgical intervention, and Group 3 consisted of horses admitted less than 24 hours after sustaining a wound.
Results of the Study
- Significant decreases in median plasma SAA levels were observed in Group 1 horses between 48 hours and 96 hours post-surgery, and between 96 hours post-surgery and six days post-surgery.
- For Group 2 horses, initial plasma SAA concentrations were very high, and they remained high or increased after the first surgical intervention.
- In Group 3 horses, low SAA values were recorded at admission, with peak concentrations at 48 hours post-surgery, followed by a gradual decrease in plasma SAA concentration over time.
Conclusion of the Study
- The researchers concluded that a reduction in plasma SAA levels between two successive measurements could indicate a positive response to treatment.
- This suggests that serial SAA measurements could serve as a rapid, inexpensive, and straightforward tool for monitoring treatment response in otherwise healthy horses with injuries penetrating synovial structures.
- The researchers, however, noted that more research is needed to confirm the clinical utility of this monitoring method.
Cite This Article
APA
Haltmayer E, Schwendenwein I, Licka TF.
(2017).
Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study.
BMC Vet Res, 13(1), 137.
https://doi.org/10.1186/s12917-017-1057-9 Publication
Researcher Affiliations
- Department of Small Animals and Horses, Clinic for Horses, Equine Surgery, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210, Vienna, Austria. Eva.Haltmayer@vetmeduni.ac.at.
- Department of Pathobiology, Clinical Pathology, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210, Vienna, Austria.
- Department of Small Animals and Horses, Clinic for Horses, Equine Surgery, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210, Vienna, Austria.
- Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, Scotland.
MeSH Terms
- Animals
- Biomarkers
- Female
- Horses / blood
- Horses / injuries
- Horses / surgery
- Male
- Serum Amyloid A Protein / analysis
- Synovial Membrane / injuries
- Treatment Outcome
- Wounds, Penetrating / blood
- Wounds, Penetrating / surgery
- Wounds, Penetrating / veterinary
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