Critical test evaluations of oxfendazole and trichlorfon: effectiveness of a paste formulation in the horse.

This research study investigates the effectiveness of a paste formulation combining oxfendazole and trichlorfon as a treatment for horse parasites. The findings suggest that the treatment is highly effective in eradicating various forms of parasites, with no negative side effects observed in the trial horses.

Research Methodology

• The researchers performed critical tests on six horses to assess the performance of the anti-parasitic paste. The paste in question combined two active ingredients, oxfendazole and trichlorfon, administered at 2.5 and 40 mg/kg of body weight, respectively.
• The paste was delivered orally as a single dose, offering a practical and non-invasive treatment method.

Findings and Results

• The dual anti-parasitic activity of oxfendazole and trichlorfon proved to be 100% effective in removing several adult parasites, including Strongylus vulgaris, S edentatus, Oxyuris equi, Parascaris equorum, the 4th stage of O equi, and the 2nd and 3rd instars of Gasterophilus nasalis.
• The combined paste also demonstrated notable effectiveness against the 2nd and 3rd stage instars of G intestinalis, with removal rates of 98.1% and 98.8% respectively.
• Nematodes categorized as “small strongyle” were removed at a combined rate of 97.0%.
• The paste formulation also showed significant larvicidal effects, as established through the cultivation of fecal nematode eggs during the trial. This indicates the treatment’s potential in disrupting the lifecycle of the parasites and preventing reinfection.
• Importantly, no adverse effects were observed in any of the six horses tested, suggesting the treatment is safe and well-tolerated.

Conclusion

• This study provides strong support for the effectiveness of the investigated paste formulation of oxfendazole and trichlorfon as a comprehensive antiparasitic treatment for horses.
• The results suggest its potential as a viable, safe, and highly effective solution for managing a variety of equine parasites, contributing valuable insights to veterinary pharmacology.