Critical tests of thiabendazole, oxibendazole, and oxfendazole for drug resistance of population-B equine small strongyles (1989 and 1990).
Abstract: Critical tests were conducted in horses (n = 11) with naturally acquired infections of benzimidazole (BZ)-resistant population-B small strongyles in 1989 and 1990. Anthelmintics administered were thiabendazole (44 mg/kg of body weight, n = 4), oxibendazole (10 mg/kg, n = 3), and oxfendazole (OFZ, 10 mg/kg; n = 4). All compounds were paste formulations administered orally except for 1 of the OFZ treatments, which was a suspension formulation given by stomach tube. Aggregate mean efficacy was calculated for all species of small strongyles, drug-resistant and non-resistant. The highest efficacy was for oxibendazole (98%) and OFZ (94%); efficacy for thiabendazole was 63%. Five genera and 16 species of small strongyles were recovered from the 11 horses, ranging from 7 to 13 species (mean, 11). Of these, 7 species were found to have resistance in variable degrees to most of the anthelmintics. These strongyles were Cyathostomum catinatum, Cyathostomum coronatum, Cylicocyclus nassatus, Cylicostephanus calicatus, Cylicostephanus goldi, Cylicostephanus longibursatus, and Cylicostephanus minutus. The large strongyle, Strongylus vulgaris, was present in all 11 test horses, and efficacy was 100% for all drugs. Seven of the BZ-treated foals (at least 1 horse from each BZ-treatment group), were infected with S edentatus; removal was 100%.
Publication Date: 1993-06-01 PubMed ID: 8323061
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- Journal Article
Summary
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The research investigates the efficacy of three drugs – thiabendazole, oxibendazole, and oxfendazole – in dealing with the drug-resistant population-B small strongyles in horses. It was found that oxibendazole and oxfendazole had the highest efficacy rates, and a number of the small strongyles were found to vary in their resistance to the drugs.
Overview of the Research
- The study was conducted on 11 horses that had naturally acquired infections of small strongyles, which were of the benzimidazole (BZ) resistant population-B type.
- In terms of the anthelmintics (anti-parasitic drugs) administered, the research used three medicine – thiabendazole (4 horses), oxibendazole (3 horses), and oxfendazole (OFZ, 4 horses).
- All the formulations were given orally, except for one of the oxfendazole treatments that was administered as a suspension via a stomach tube.
Findings from the Study
- The study tabulated an aggregate mean efficacy for all species of small strongyles, comprising both the drug resistant and non-resistant types.
- It was found that oxibendazole (98%) and oxfendazole (94%) had the highest efficacy; while thiabendazole recorded an efficacy rate of 63%.
- A total of five genera and 16 species of small strongyles were found from the 11 horses, with the horses showing a range of 7 to 13 species each (average 11).
- Seven out of these sixteen species exhibited varying degrees of resistance to a majority of the anthelmintics used.
- The large strongyle, Strongylus vulgaris, was present in all the horses and responded at a 100% efficacy rate for all the three drugs.
- Furthermore, seven of the foals that were treated with benzimidazole were infected with S edentatus, and all of them observed a 100% removal rate.
Cite This Article
APA
Tolliver SC, Lyons ET, Drudge JH, Stamper S, Granstrom DE.
(1993).
Critical tests of thiabendazole, oxibendazole, and oxfendazole for drug resistance of population-B equine small strongyles (1989 and 1990).
Am J Vet Res, 54(6), 908-913.
Publication
Researcher Affiliations
- Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington 40546-0099.
MeSH Terms
- Animals
- Anthelmintics / therapeutic use
- Benzimidazoles / therapeutic use
- Drug Resistance
- Female
- Horses
- Male
- Strongyle Infections, Equine / drug therapy
- Strongylus / drug effects
- Thiabendazole / therapeutic use
Citations
This article has been cited 6 times.- Garge RK, Cha HJ, Lee C, Gollihar JD, Kachroo AH, Wallingford JB, Marcotte EM. Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. Genetics 2021 Aug 26;219(1).
- Lyons ET, Kuzmina TA, Tolliver SC, Collins SS. Observations on development of natural infection and species composition of small strongyles in young equids in Kentucky. Parasitol Res 2011 Dec;109(6):1529-35.
- Lyons ET, Tolliver SC, Collins SS. Study (1991 to 2001) of drug-resistant Population B small strongyles in critical tests in horses in Kentucky at the termination of a 40-year investigation. Parasitol Res 2007 Aug;101(3):689-701.
- Lyons ET, Tolliver SC, Collins SS. Prevalence of large endoparasites at necropsy in horses infected with Population B small strongyles in a herd established in Kentucky in 1966. Parasitol Res 2006 Jul;99(2):114-8.
- Kuzmina TA, Königová A, Antipov A, Kuzmin Y, Kharchenko V, Syrota Y. Changes in equine strongylid communities after two decades of annual anthelmintic treatments at the farm level. Parasitol Res 2024 Nov 25;123(11):394.
- Kuzmina TA, Königová A, Burcáková L, Babjak M, Syrota Y. Strongylids of Domestic Horses in Eastern Slovakia: Species Diversity and Evaluation of Particular Factors Affecting Strongylid Communities. Acta Parasitol 2024 Jun;69(2):1284-1294.
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