Critical tests with oxibendazole against gastrointestinal parasites of ponies.
Abstract: Twenty ponies were allotted to 4 groups of 5 ponies each, and oxibendazole was orally administered at dose levels of 5, 10, 15, and 20 mg/kg. In the 3 groups of ponies given the largest doses, efficacy against 3 species of Strongylus was between 92 and 100% and that against small strongylids of the genera Cyathostomum, Cylicocyclus, Cylicodontophorus, and Cylicostephanus was more than 99%. All adults and 95 to 100% of larvae of the pinworm Oxyuris equi were removed. In the group of ponies given 5 mg/kg, 86 to 100% of the large strongylids and 84 to 100% of the small strongylids were removed, as were all larval and adult pinworms. Trichostrongylus axei was found only in 4 of the 5 ponies given 5 mg/kg; results were encouraging, but not consistent. Almost all of the Parascaris equorum were found in this group of ponies; no anthelmintic activity was detected at this dose level. Oxibendazole removed approximately 99% of small strongylid 4th-stage larvae. No efficacy against the larval stages of Gasterophilus intestinalis and against Habronema spp and Setaria equina was observed.
Publication Date: 1976-04-01 PubMed ID: 1267243
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- Journal Article
Summary
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This research study tested the effectiveness of oxibendazole, an anthelmintic drug, in eradicating various species of gastrointestinal parasites in ponies. The results varied based on the dosage administered and the type of parasite, but overall the drug was highly effective against several species of strongylids and pinworms.
Research Methodology
- Twenty ponies were randomly allocated into four groups, each containing five ponies.
- Oxibendazole was administered orally at different dosage levels: 5, 10, 15, and 20 mg/kg.
- The effectiveness of each dose was measured by the percentage of different types of parasites removed.
Results for Large and Small Strongylids
- For the three groups of ponies given the largest doses of oxibendazole, effectiveness rates against three species of Strongylus parasites ranged from 92 to 100%.
- Moreover, the same dosage was more than 99% effective against small strongylids of the genera Cyathostomum, Cylicocyclus, Cylicodontophorus, and Cylicostephanus.
- In the group of ponies given the smallest dose (5 mg/kg), the removal rates of large strongylids and small strongylids ranged from 86 to 100% and 84 to 100% respectively.
Results for Pinworms and Trichostrongylus axei
- Oxibendazole effectively removed all adult pinworms (Oxyuris equi) and between 95 to 100% of larvae across all groups.
- Trichostrongylus axei was found only in four of the five ponies that were administered the smallest dose. The findings were promising but inconsistent.
Results for Parascaris equorum and Small Strongylid 4th-stage Larvae
- Almost all of the Parascaris equorum were found in the group of ponies administered 5 mg/kg; no anthelmintic activity was detected at this dose level.
- Oxibendazole was capable of removing approximately 99% of small strongylid 4th-stage larvae.
Results for Gasterophilus intestinalis, Habronema spp, and Setaria equina
- However, the drug showed no efficacy against the larval stages of Gasterophilus intestinalis
- Similarly, no anthelminthic activity was observed against Habronema spp and Setaria equina.
In summary, the study establishes the high efficiency of oxibendazole against several species of gastrointestinal parasites in ponies, with the degree of efficacy varying with the dose level and the type of parasite. Some parasites showed resistance to the drug, highlighting the need for additional research.
Cite This Article
APA
Nawalinski T, Theodorides VJ.
(1976).
Critical tests with oxibendazole against gastrointestinal parasites of ponies.
Am J Vet Res, 37(4), 469-471.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Benzimidazoles / therapeutic use
- Carbamates / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Intestinal Diseases, Parasitic / drug therapy
- Intestinal Diseases, Parasitic / veterinary
- Male
- Nematode Infections / drug therapy
- Nematode Infections / veterinary
- Oxyuriasis / drug therapy
- Oxyuriasis / veterinary
- Stomach Diseases / drug therapy
- Stomach Diseases / veterinary
- Strongyle Infections, Equine / drug therapy
Citations
This article has been cited 1 times.- Slocombe JO, Cote JF, McMillan I. Effectiveness of oxibendazole against benzimidazole-resistant strongyles in horses. Can Vet J 1989 Aug;30(8):663-5.
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