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Mediators of inflammation2013; 2013; 420186; doi: 10.1155/2013/420186

Cytokines and angiogenesis in the corpus luteum.

Abstract: In adults, physiological angiogenesis is a rare event, with few exceptions as the vasculogenesis needed for tissue growth and function in female reproductive organs. Particularly in the corpus luteum (CL), regulation of angiogenic process seems to be tightly controlled by opposite actions resultant from the balance between pro- and antiangiogenic factors. It is the extremely rapid sequence of events that determines the dramatic changes on vascular and nonvascular structures, qualifying the CL as a great model for angiogenesis studies. Using the mare CL as a model, reports on locally produced cytokines, such as tumor necrosis factor α (TNF), interferon gamma (IFNG), or Fas ligand (FASL), pointed out their role on angiogenic activity modulation throughout the luteal phase. Thus, the main purpose of this review is to highlight the interaction between immune, endothelial, and luteal steroidogenic cells, regarding vascular dynamics/changes during establishment and regression of the equine CL.
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Publication Date: 2013-06-11 PubMed ID: 23840095PubMed Central: PMC3693155DOI: 10.1155/2013/420186Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research focuses on the role of cytokines in the angiogenesis process, particularly in the corpus luteum of the female reproductive system. The study uses the mare corpus luteum as a model to investigate the interaction between immune, endothelial, and luteal steroidogenic cells, considering how these interactions contribute to vascular changes during the equine corpus luteum’s development and regression.

Background on Angiogenesis and the Corpus Luteum

  • The study notes that physiological angiogenesis, or the formation of new blood vessels, is uncommon in adults, except for specific instances such as the growth and function of tissue in female reproductive organs.
  • Particularly, the corpus luteum (CL), a temporary endocrine structure in female mammals, has a tightly regulated angiogenesis process, which is balanced by both pro- and antiangiogenic factors.
  • Within the CL, the quick sequence of events results in significant changes in both vascular and nonvascular structures, making it a fruitful area for angiogenesis studies.

Role of Cytokines in Angiogenesis

  • The research focuses on cytokines produced locally, including tumor necrosis factor α (TNF), interferon gamma (IFNG), or Fas ligand (FASL), which are believed to modulate angiogenic activity throughout the luteal phase.
  • The interaction between immune cells, endothelial cells (cells that line the inner surface of blood vessels), and steroidogenic cells (cells that produce steroids) plays a key role in vascular dynamics and changes.

Objective of the Study

  • The primary objective of this review is to underline the interaction between these cells and how it affects vascular changes when establishing and regressing the equine corpus luteum.
  • Understanding this interaction can provide valuable insights into reproductive biology and could potentially inform treatments for conditions related to vascular growth and regression.

Cite This Article

APA
Galvão AM, Ferreira-Dias G, Skarzynski DJ. (2013). Cytokines and angiogenesis in the corpus luteum. Mediators Inflamm, 2013, 420186. https://doi.org/10.1155/2013/420186

Publication

Mediators of inflammation
ISSN: 1466-1861
NlmUniqueID: 9209001
Country: United States
Language: English
Volume: 2013
Pages: 420186
PII: 420186

Researcher Affiliations

Galvão, António M
  • CIISA, Department of Morphology and Function, Faculty of Veterinary Medicine, Technical University of Lisbon, Lisboa, Portugal. agalvao@fmv.utl.pt
Ferreira-Dias, Graça
    Skarzynski, Dariusz J

      MeSH Terms

      • Animals
      • Corpus Luteum / metabolism
      • Cytokines / metabolism
      • Fas Ligand Protein / metabolism
      • Female
      • Horses
      • Interferon-gamma / metabolism
      • Neovascularization, Physiologic / physiology
      • Tumor Necrosis Factor-alpha / metabolism

      References

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