Deficiency of interferon-gamma but not interferon-beta in Arabian foals with severe combined immunodeficiency.
Abstract: The results of a study on the induction of IFN-alpha, IFN-beta, and IFN-gamma in normal and SCID foals showed a deficiency of IFN-gamma but not IFN-beta in SCID foals. The ability of SCID mononuclear cells to produce IFN-alpha in response to poly I:C but not to NDV may indicate a partial deficiency of IFN-alpha in SCID foals. The deficiency of IFN-gamma and presence of IFN-beta in SCID foals supports the classification of IFN-gamma and IFN-beta as immune and nonimmune interferons, respectively. Furthermore, the deficiency of IFN-gamma in SCID foals may in part explain the high susceptibility to infections observed in SCID foals.
Publication Date: 1982-09-01 PubMed ID: 6180003
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The study reveals that Arabian foals suffering from severe combined immunodeficiency (SCID) display a lack of interferon-gamma (IFN-gamma), but not Interferon-beta (IFN-beta), which may partially explain their increased vulnerability to infections.
Understanding SCID in Arabian Foals
- This research focused on Arabian foals suffering from Severe Combined Immunodeficiency (SCID), a prevalent disorder in Arabian horse breeds that leads to an increased frequency and severity of infections due to a dysfunctional immune system.
Interferons and Their Role
- The study delved into three specific interferons (IFN-alpha, IFN-beta, and IFN-gamma) and their induction levels. Interferons are proteins released by host cells in response to pathogens, including viruses, bacteria, parasites, and tumor cells, playing critical roles in the immune system’s defense mechanism.
- Specifically, IFN-gamma is an immune interferon, while IFN-beta is a nonimmune interferon, meaning that the former plays an essential role in immunity, while the latter does not bear direct responsibility for immune reactions.
Findings From the Research
- The researchers observed that foals with SCID displayed a deficiency of IFN-gamma. The lack of this important immune interferon could in part elucidate the high susceptibility to infections seen in SCID foals.
- On the other hand, no deficiency was observed in IFN-beta, reinforcing its classification as a nonimmune interferon; this absence signifies that its presence does not directly impact immunity, thus, having no direct effect on the susceptibility to infections.
- The research also showed partial deficiency of IFN-alpha in response to specific pathogens, indicating it might play a role in combating certain infections.
- The results strengthen the understanding of interferons’ roles and their deficiencies in SCID affected foals.
Implications of the Study
- The research findings could potentially aid in finding a better understanding and treatments for SCID in Arabian foals in particular and immunodeficiency disorders in general.
- Furthermore, a detailed understanding of the differential roles of interferons may offer targeted therapeutic options
Cite This Article
APA
Yilma T, Perryman LE, McGuire TC.
(1982).
Deficiency of interferon-gamma but not interferon-beta in Arabian foals with severe combined immunodeficiency.
J Immunol, 129(3), 931-933.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cells, Cultured
- Concanavalin A / pharmacology
- Female
- Horse Diseases / immunology
- Horses
- Immunologic Deficiency Syndromes / immunology
- Immunologic Deficiency Syndromes / veterinary
- Interferons / biosynthesis
- Interferons / deficiency
- Monocytes / immunology
Grant Funding
- HD08886 / NICHD NIH HHS
- RR05465-19 / NCRR NIH HHS
Citations
This article has been cited 1 times.- Heagy W, Kelley VE, Strom TB, Mayer K, Shapiro HM, Mandel R, Finberg R. Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-gamma. J Clin Invest 1984 Dec;74(6):2089-96.
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