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Journal of veterinary internal medicine2007; 21(2); 293-301; doi: 10.1892/0891-6640(2007)21[293:dolcib]2.0.co;2

Determination of lactate concentrations in blood plasma and peritoneal fluid in horses with colic by an Accusport analyzer.

Abstract: Intestinal hypoperfusion can lead to increased lactate concentrations in plasma and peritoneal fluid of horses with colic. Objective: The purposes of this study were to (1) evaluate the reliability of the Accusport analyzer to assess peritoneal fluid lactate (PFL) concentrations in healthy horses and those with colic, (2) identify clinical features associated with abnormal blood plasma lactate (BPL) and PFL concentrations, and (3) evaluate the prognostic value of BPL and PFL. Methods: BPL and PFL were determined in 20 healthy horses and in 106 horses with colic. Results: The Accusport was reliable for determining BPL concentrations < 13 mM and PFL concentrations < 20 mM. Multivariate analysis indicated that PCV and the need for intestinal resection were independently associated with the BPL; pulse, PCV, venous pO2, the presence of necrotic intestine, an increased amount of peritoneal fluid, and fluid total protein content were independently associated with PFL. With a 1 mM increase in BPL or PFL, the respective odds ratios for required abdominal surgery increase to 1.23 (BPL) and 1.58 (PFL), odds ratios for a required intestinal resection increase to 1.20 (BPL) and 1.41 (PFL), and odds ratios for developing ileus increase by 1.33 (BPL) and 1.36 (PFL). PFL concentrations of 1, 6, 12, and 16 mM correspond to a probability of death of 11, 29, 63, and 82%, respectively, in horses without strangulating obstruction and of 25, 52, 82, and 92%, respectively, in horses with strangulating obstruction. Conclusions: PFL is more useful and sensitive than BPL for prognostic purposes in horses with colic.
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Publication Date: 2007-04-13 PubMed ID: 17427391DOI: 10.1892/0891-6640(2007)21[293:dolcib]2.0.co;2Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research studied the reliability of the Accusport analyzer in measuring lactate concentrations in blood and peritoneal fluid in healthy horses versus those with colic. It also identified clinical features connected to abnormal lactate concentrations and evaluated the prognostic value of these measurements. The Accusport analyzer was found to be reliable and pointed to increased chances of needed surgery and death with growing lactate concentrations, particularly in the peritoneal fluid.

Reliability of Accusport Analyzer

  • The study first focused on determining the reliability of the Accusport analyzer for measuring lactate concentrations in the blood plasma and peritoneal fluid of horses.
  • The experiment was first conducted on 20 healthy horses, and then on 106 horses suffering from colic.
  • Findings indicated that the analyzer could reliably determine blood plasma lactate (BPL) concentrations less than 13 mM and peritoneal fluid lactate (PFL) concentrations less than 20 mM.

Identifying Clinical Associations

  • The study next turned to identifying clinical features associated with abnormal BPL and PFL concentrations in horses.
  • Through multivariate analysis, it was identified that PCV (Packed Cell Volume) and the need for intestinal resection were independently linked to BPL. Conversely, pulse, PCV, venous pO2 (partial pressure of Oxygen), the presence of necrotic intestine, increased amount of peritoneal fluid, and fluid total protein content were associated with PFL.

Evaluating Prognostic Value

  • The research further evaluated the prognostic value of BPL and PFL in determining the outcome for horses with colic.
  • Findings indicated that every 1 mM increase in BPL or PFL significantly increased the odds ratios for required abdominal surgery, intestinal resection, and the development of ileus (a disruption of the normal propulsive ability of the gastrointestinal tract).
  • Increased PFL concentrations, especially, were associated with a high probability of death in horses with colic, a higher value signifying a higher risk. The study concluded that PFL proves more sensitive than BPL for prognostic purposes in horses with colic.

Cite This Article

APA
Delesalle C, Dewulf J, Lefebvre RA, Schuurkes JA, Proot J, Lefere L, Deprez P. (2007). Determination of lactate concentrations in blood plasma and peritoneal fluid in horses with colic by an Accusport analyzer. J Vet Intern Med, 21(2), 293-301. https://doi.org/10.1892/0891-6640(2007)21[293:dolcib]2.0.co;2

Publication

Journal of veterinary internal medicine
ISSN: 0891-6640
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 21
Issue: 2
Pages: 293-301

Researcher Affiliations

Delesalle, Cathérine
  • Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Catherine.Delesalle@UGent.be
Dewulf, Jeroen
    Lefebvre, Romain A
      Schuurkes, Jan A J
        Proot, Joachim
          Lefere, Laurence
            Deprez, Piet

              MeSH Terms

              • Animals
              • Ascitic Fluid / chemistry
              • Biomarkers / analysis
              • Biomarkers / blood
              • Blood Chemical Analysis / instrumentation
              • Blood Chemical Analysis / veterinary
              • Colic / metabolism
              • Colic / veterinary
              • Female
              • Horse Diseases / metabolism
              • Horses
              • Lactates / analysis
              • Lactates / blood
              • Male

              Citations

              This article has been cited 15 times.
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