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Determination of physiological dead space in anaesthetized horses: a method-comparison study.
Abstract: To compare two methods of Bohr-Enghoff physiological dead space to tidal volume ratio (Vd/Vt) determination using a mixing chamber and an E-CAiOVX metabolic monitor. Methods: Prospective, clinical, method-comparison study. Methods: Twenty horses anaesthetized for elective orthopaedic procedures. Methods: Horses were anaesthetized with isoflurane in oxygen and the lungs were mechanically ventilated (Vt 15±2 mL kg). Arterial blood was sampled to provide arterial partial pressure of carbon dioxide (PaCO) for dead space calculation using a metabolic monitor. Mixed expired partial pressure of carbon dioxide (PēCO) obtained from the custom-made mixing chamber was recorded at the time of arterial blood sampling. Dead space fraction was calculated using the Enghoff modification of the Bohr equation. Agreement between the methods was assessed by Bland-Altman test. A clinically acceptable error was defined to be ≤ 10%. Results: Forty-nine simultaneous Vd/Vt results were obtained. There was no clinically significant bias between the mixing chamber and E-CAiOVX. The limits of agreement were within a priori defined error (bias±95% limits of agreement: -0.022±0.078). Conclusions: Acceptable agreement was found between the two methods. The E-CAiOVX metabolic monitor might be a suitable device for measuring Vd/Vt in anaesthetized horses.
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2017-04-18 PubMed ID: 29246713DOI: 10.1016/j.vaa.2017.04.003Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
Summary
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The research evaluates the accuracy of two methods for calculating physiological dead space to tidal volume ratio (Vd/Vt) in anaesthetized horses. The researchers found both methods to be comparably reliable, suggesting the E-CAiOVX metabolic monitor can be used successfully in this scenario.
Objective and Methodology
- The study aimed to compare two methods for determining Bohr-Enghoff physiological dead space to tidal volume ratio (Vd/Vt) in anaesthetized horses. The two methods being compared were a mixing chamber and an E-CAiOVX metabolic monitor.
- This was a prospective, clinical, method-comparison study that involved twenty horses who were anaesthetized for elective orthopaedic procedures.
- The horses were anaesthetized with isoflurane in oxygen, and their lungs were mechanically ventilated. Arterial blood was sampled to provide the arterial partial pressure of carbon dioxide (PaCO) needed for dead space calculations using a metabolic monitor.
Data Collection and Analysis
- The mixed expired partial pressure of carbon dioxide (PēCO) was obtained from a custom-made mixing chamber at the time of arterial blood sampling. The dead space fraction was calculated using the Enghoff modification of the Bohr equation.
- The researchers compared the results from both methods by applying the Bland-Altman test.
- A clinically acceptable error was defined as being less than or equal to 10%.
Results
- The researchers obtained 49 simultaneous Vd/Vt results and found no clinically significant bias between the results from the mixing chamber and the E-CAiOVX metabolic monitor.
- The limits of agreement were within previously defined error margins, further validating the reliability of both methods.
Conclusions
- The study concludes that both methods demonstrated acceptable agreement and the E-CAiOVX metabolic monitor is a suitable device for measuring Vd/Vt in anaesthetized horses.
- This finding could contribute to the improved health management of horses, particularly those undergoing anaesthesia for orthopaedic procedures.
Cite This Article
APA
Drábková Z, Schramel JP, Kabeš R.
(2017).
Determination of physiological dead space in anaesthetized horses: a method-comparison study.
Vet Anaesth Analg, 45(1), 73-77.
https://doi.org/10.1016/j.vaa.2017.04.003 Publication
Researcher Affiliations
- Equine Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic. Electronic address: drabkovaz@vfu.cz.
- Anaesthesiology and Perioperative Intensive Care Medicine, University of Veterinary Medicine Vienna, Vienna, Austria.
- Equine Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
MeSH Terms
- Anesthesia, Inhalation / adverse effects
- Anesthesia, Inhalation / methods
- Anesthesia, Inhalation / veterinary
- Animals
- Blood Gas Analysis / veterinary
- Female
- Horses / physiology
- Male
- Respiratory Dead Space / physiology
- Tidal Volume
Citations
This article has been cited 1 times.- Stefanik E, Drewnowska O, Lisowska B, Turek B. Causes, Effects and Methods of Monitoring Gas Exchange Disturbances during Equine General Anaesthesia. Animals (Basel) 2021 Jul 9;11(7).
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