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Clinical and vaccine immunology : CVI2006; 13(2); 297-300; doi: 10.1128/CVI.13.2.297-300.2006

Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection.

Abstract: In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas IgG(T) was detected only after resolution of acute parasitemia. The same IgG isotype profile induced during acute infection was obtained by equi merozoite antigen 1/saponin immunization.
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Publication Date: 2006-02-10 PubMed ID: 16467341PubMed Central: PMC1391941DOI: 10.1128/CVI.13.2.297-300.2006Google Scholar: Lookup
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  • Journal Article
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  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the relationship between the development of specific antibodies and the control of parasitic infection in horses. It was observed that the presence of certain immunoglobulins corresponded with resolution of acute parasitemia associated with Babesia equi infection.

Introduction

The study focuses on understanding the changes in immunoglobulin G (IgG) types in horses during an infection by Babesia equi, a parasitic organism. The investigation is centered around two specific variants of IgG (IgGa and IgGb), and their emergence during the acute phase of the infection, and IgG(T) which made its appearance after the acute parasitemia was resolved.

Methodology

  • The researchers studied the temporal characteristics of IgG isotype in horses infected with Babesia equi.
  • Detailed attention was given to IgGa and IgGb antibodies during the acute phase and IgG(T) post the resolution of acute parasitemia.
  • They also analyzed the IgG subtypes generated for equi merozoite antigen 1/saponin immunization, which mirrored the pattern seen during acute infection.

Results

  • The study found that the development of IgGa and IgGb antibodies were prominent during the acute phase of Babesia equi infection in horses.
  • Interestingly, the occurrence of IgG(T) was only seen post the resolution of acute parasitemia; thus, their appearance signals control over the infection.
  • The same pattern of IgG isotype profile observed during acute infection was also produced by equi merozoite antigen 1/saponin immunization, suggesting the immunization can effectively mimic the natural immune response to infection.

Conclusion

The research concluded that the
development of IgGa and IgGb antibodies correlates with the onset of acute parasitemia in Babesia equi infection while the presence of IgG(T) indicates the resolution of acute parasitemia. The study also found the isotype profile generated by the equi merozoite antigen 1/saponin immunization to be identical to the one produced during the acute infection. These findings can pave the way for developing targeted therapeutic strategies for Babesia equi infections.

Cite This Article

APA
Cunha CW, McGuire TC, Kappmeyer LS, Hines SA, Lopez AM, Dellagostin OA, Knowles DP. (2006). Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection. Clin Vaccine Immunol, 13(2), 297-300. https://doi.org/10.1128/CVI.13.2.297-300.2006

Publication

Clinical and vaccine immunology : CVI
ISSN: 1556-6811
NlmUniqueID: 101252125
Country: United States
Language: English
Volume: 13
Issue: 2
Pages: 297-300

Researcher Affiliations

Cunha, Cristina W
  • Washington State University, Department of Veterinary Microbiology and Pathology, Pullman, WA 99164-7040, USA. cwcunha@vetmed.wsu.edu
McGuire, Travis C
    Kappmeyer, Lowell S
      Hines, Stephen A
        Lopez, A Marianela
          Dellagostin, Odir A
            Knowles, Donald P

              MeSH Terms

              • Animals
              • Antibodies, Protozoan / biosynthesis
              • Babesia / immunology
              • Babesiosis / immunology
              • Babesiosis / parasitology
              • Babesiosis / veterinary
              • Enzyme-Linked Immunosorbent Assay
              • Horse Diseases / immunology
              • Horse Diseases / parasitology
              • Horses
              • Immunoglobulin G / biosynthesis
              • Immunoglobulin G / classification
              • Immunoglobulin Isotypes / biosynthesis
              • Parasitemia / immunology
              • Parasitemia / parasitology
              • Parasitemia / veterinary
              • Time Factors

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              Citations

              This article has been cited 7 times.
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