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The Canadian veterinary journal = La revue veterinaire canadienne2006; 47(7); 689-691;

Diagnostic and epidemiological features of Lawsonia intracellularis enteropathy in 2 foals.

Abstract: Two clinical cases of equine proliferative enteropathy are described. Both foals had a positive fecal polymerase chain reaction, but shedding of the bacterium stopped <4 days after therapy was initiated. One foal was serologically positive 3 days after onset of clinical signs and remained positive for more than 6 months. Diagnostic et aspects épidémiologiques d’une entéropathie à Lawsonia intracellularis chez 2 poulains. L’article décrit 2 cas cliniques d’entéropathie proliférative équine. Les 2 poulains étaient positifs à un test fécal d’amplification en chaîne par polymérase mais l’élimination s’est arrêtée < 4 jour après le début du traitement. Un poulain était sérologiquement positif 3 jours après le début des signes cliniques et est demeuré positif pour plus de 6 mois. (Traduit par Docteur André Blouin)
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Publication Date: 2006-08-11 PubMed ID: 16898113PubMed Central: PMC1482453
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study focuses on the diagnostic and epidemiological features of Lawsonia intracellularis enteropathy, a bacterial infection, in two cases involving foals. Using fecal polymerase chain reaction testing, they found that the bacteria stopped shedding in less than four days following the initiation of therapy. One of the treated foals demonstrated a serological response three days post-disease onset and remained positive for over six months.

Objective and Methodology of the Study

  • The main concern of the study stands to explore the diagnostic and epidemiological features of a bacterial infection, Lawsonia intracellularis, in young horses.
  • The study headquartered on two foals exhibiting symptoms pertaining to equine proliferative enteropathy.
  • The researchers employed fecal polymerase chain reaction tests to identify presence of the bacterium in the subjects.

Key Findings

  • Following the detection of the bacteria, appropriate therapeutic measures were implemented.
  • After the initiation of treatment, both foals ceased to shed the bacterium in less than four days, indicating a positive response to the treatment.
  • In the follow-up study, blood tests revealed that one foal demonstrated a positive serological response just three-day post the onset of clinical signs.
  • This positive serological response was persistent for a period extending over six months, showcasing the effectiveness of the treatment.

Conclusion

  • The study successfully amplifies the understanding of Lawsonia intracellularis enteropathy and its epidemiological and diagnostic features in foals.
  • Through fecal polymerase chain reaction testing, efficient detection and monitoring of the bacterium were feasible.
  • The results of the study suggest the potential efficacy of the treatment used in eliminating the bacteria, hinting towards promising therapeutic strategies for managing this particular enteropathy in future.

Cite This Article

APA
Dauvillier J, Picandet V, Harel J, Gottschalk M, Desrosiers R, Jean D, Lavoie JP. (2006). Diagnostic and epidemiological features of Lawsonia intracellularis enteropathy in 2 foals. Can Vet J, 47(7), 689-691.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 47
Issue: 7
Pages: 689-691

Researcher Affiliations

Dauvillier, Julie
  • Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Sicotte, Saint-Hyacinthe, Québec.
Picandet, Valérie
    Harel, Josée
      Gottschalk, Marcelo
        Desrosiers, Robert
          Jean, Daniel
            Lavoie, Jean-Pierre

              MeSH Terms

              • Animals
              • Animals, Newborn
              • Anti-Bacterial Agents / therapeutic use
              • Desulfovibrionaceae Infections / diagnosis
              • Desulfovibrionaceae Infections / drug therapy
              • Desulfovibrionaceae Infections / epidemiology
              • Desulfovibrionaceae Infections / veterinary
              • Feces / microbiology
              • Horse Diseases / diagnosis
              • Horse Diseases / drug therapy
              • Horse Diseases / epidemiology
              • Horses
              • Lawsonia Bacteria / isolation & purification
              • Lawsonia Bacteria / pathogenicity
              • Male
              • Polymerase Chain Reaction / methods
              • Polymerase Chain Reaction / veterinary
              • Treatment Outcome

              References

              This article includes 15 references
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              Citations

              This article has been cited 6 times.
              1. Engiles JB, Uzal FA, Navarro MA, Reef VB, Bender SJ. Phlegmonous gastritis in 2 yearling horses. J Vet Diagn Invest 2022 May;34(3):429-438.
                doi: 10.1177/10406387211065044pubmed: 35000510google scholar: lookup
              2. Pusterla N, Gebhart C. Equine proliferative enteropathy caused by Lawsonia intracellularis. Equine Vet Educ 2009 Aug;21(8):415-419.
                doi: 10.2746/095777309X453119pubmed: 32313386google scholar: lookup
              3. Ueno Y, Uemura R, Niwa H, Higuchi T, Sekiguchi S, Sasaki Y, Sueyoshi M. Total serum protein reference value as a clinical diagnostic index of equine proliferative enteropathy. J Equine Sci 2019 Sep;30(3):63-67.
                doi: 10.1294/jes.30.63pubmed: 31592224google scholar: lookup
              4. Bohlin AM, Olsen SN, Laursen SH, Öhman A, van Galen G. Lawsonia intracellularis associated equine proliferative enteropathy in Danish weanling foals. Acta Vet Scand 2019 Mar 8;61(1):12.
                doi: 10.1186/s13028-019-0447-3pubmed: 30850006google scholar: lookup
              5. Pusterla N, Gebhart C. Lawsonia intracellularis infection and proliferative enteropathy in foals. Vet Microbiol 2013 Nov 29;167(1-2):34-41.
                doi: 10.1016/j.vetmic.2013.06.017pubmed: 23871678google scholar: lookup
              6. Pusterla N, Gebhart CJ. Equine proliferative enteropathy--a review of recent developments. Equine Vet J 2013 Jul;45(4):403-9.
                doi: 10.1111/evj.12075pubmed: 23662705google scholar: lookup
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