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Home / Equine Research Bank / J Vet Intern Med / Diagnostic value of noninvasive pulse pressure measurements ...
Journal of veterinary internal medicine2019; 33(3); 1446-1455; doi: 10.1111/jvim.15494

Diagnostic value of noninvasive pulse pressure measurements in Warmblood horses with aortic regurgitation.

Abstract: Noninvasive blood pressures (NIBP) and pulse pressures (PP) have not been published in horses with aortic and mitral regurgitation (AR or MR). Objective: To investigate NIBP and PP in healthy Warmblood horses and horses with AR and MR and propose PP cutoffs to identify and stage AR severity. Methods: Seventy-three Warmblood horses (healthy, 10; AR, 31; MR, 32). Methods: Retrospective study. All horses had NIBP and an echocardiogram recorded. Cases were categorized based on severity of regurgitation. Pulse pressures were compared among healthy, MR, and AR groups and among AR severity groups. Cutoffs were determined by receiver operating characteristic curve analyses. Results: Horses with AR had higher PP than horses with MR (mean difference [95% confidence interval (CI)], +17 [9-26] mm Hg, P < .001) and controls (+17 [5-30] mm Hg; P =.004). Horses with severe AR had higher PP compared those with mild (+38 [20-54] mm Hg; P < 0.001) and moderate AR (+33 [18-47] mm Hg; P < .001). The PP cutoffs to distinguish AR from MR and controls were 38 mm Hg (sensitivity [Sn], 100%; specificity [Sp], 19%) for maximal Sn and 61 mm Hg (Sn, 43%; Sp, 100%) for maximal Sp. The PP cutoffs to distinguish severe AR from mild and moderate AR were 57 mm Hg (Sn, 100%; Sp, 70%) for maximal Sn and 77 mm Hg (Sn, 75%; Sp, 100%) for maximal Sp. Conclusions: Horses with AR have increased PP. Noninvasive PP measurements interpreted with provided cutoffs may aid clinicians in diagnosing and staging severity of AR in horses.
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2019-04-02 PubMed ID: 30938891PubMed Central: PMC6524107DOI: 10.1111/jvim.15494Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study which explores the use of noninvasive pulse pressure measurements to diagnose aortic regurgitation in Warmblood horses.

Objective and Methodology

  • The aim of this research is to investigate noninvasive blood pressures (NIBP) and pulse pressures (PP) in healthy Warmblood horses and those with aortic and mitral regurgitation (AR or MR).
  • The researchers proposed PP cut-offs that could serve as indicators to identify and assess the severity of AR.
  • For the purpose of this study, a total of seventy-three Warmblood horses were used. The participants included healthy horses, horses with AR, and horses with MR.
  • Pulse pressures in the horses were measured noninvasively and echocardiograms were recorded.
  • The horses were categorized based on the severity of their regurgitation, and the pulse pressures were compared among the groups with different health conditions and varying levels of AR severity.

Results

  • The study found that horses with aortic regurgitation (AR) had higher pulse pressure (PP) compared to horses with mitral regurgitation (MR) and healthy horses.
  • Additionally, horses with severe AR had notably higher PP compared to those with mild and moderate AR.
  • Cutoffs for pulse pressure were determined to distinguish between AR and MR, and between different severity levels of AR. For instance, a PP cutoff of 38 mm Hg was determined for maximal sensitivity and 61mm Hg for maximal specificity to distinguish AR from MR and healthy controls. Similarly, to distinguish severe AR from mild and moderate AR, PP cut-offs were determined as 57 mm Hg for maximal sensitivity and 77 mm Hg for maximal specificity.

Conclusion

  • The research concluded that Warmblood horses with aortic regurgitation show an increase in pulse pressure.
  • The results of noninvasive pulse pressure measurements, when interpreted with the provided cut-offs, could help in the diagnosis and assessment of severity of aortic regurgitation in horses.

Cite This Article

APA
Boegli J, Schwarzwald CC, Mitchell KJ. (2019). Diagnostic value of noninvasive pulse pressure measurements in Warmblood horses with aortic regurgitation. J Vet Intern Med, 33(3), 1446-1455. https://doi.org/10.1111/jvim.15494

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 33
Issue: 3
Pages: 1446-1455

Researcher Affiliations

Boegli, Julia
  • Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Schwarzwald, Colin C
  • Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Mitchell, Katharyn J
  • Equine Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

MeSH Terms

  • Animals
  • Aortic Valve Insufficiency / diagnosis
  • Aortic Valve Insufficiency / diagnostic imaging
  • Aortic Valve Insufficiency / veterinary
  • Blood Pressure / physiology
  • Echocardiography / veterinary
  • Female
  • Horse Diseases / diagnosis
  • Horse Diseases / diagnostic imaging
  • Horses
  • Male
  • Mitral Valve Insufficiency / diagnosis
  • Mitral Valve Insufficiency / diagnostic imaging
  • Mitral Valve Insufficiency / veterinary
  • Retrospective Studies

Conflict of Interest Statement

Colin Schwarzwald serves as Associate Editor for the Journal of Veterinary Internal Medicine. He was not involved in review of this manuscript.

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Citations

This article has been cited 2 times.
  1. Vera L, De Clercq D, Van Steenkiste G, Decloedt A, Chiers K, van Loon G. Differences in ultrasound-derived arterial wall stiffness parameters and noninvasive blood pressure between Friesian horses and Warmblood horses.. J Vet Intern Med 2020 Mar;34(2):893-901.
    doi: 10.1111/jvim.15705pubmed: 32032455google scholar: lookup
  2. Vera L, Campos Arias D, Muylle S, Stergiopulos N, Segers P, van Loon G. A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions.. PLoS One 2019;14(8):e0221425.
    doi: 10.1371/journal.pone.0221425pubmed: 31433827google scholar: lookup
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