FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
The Canadian veterinary journal = La revue veterinaire canadienne2019; 60(6); 625-629;

Do plasma protein:fibrinogen ratios in horses provide additional information compared with fibrinogen concentration alone?

Abstract: The plasma protein:fibrinogen (PP:F) ratio was introduced to aid interpretation of hyperfibrinogenemia by accounting for dehydration. However, this ratio is inconsistently assessed in practice and its clinical value remains unknown. Our objective was to determine whether the PP:F ratio provides additional information in adult horses beyond fibrinogen concentration alone. Two databases were reviewed to identify 412 hyperfibrinogenemic horses. Plasma protein:fibrinogen ratios were calculated and their interpretation compared to the fibrinogen concentration. Ratios < 15 were supportive of inflammation. Albumin and total protein concentrations were evaluated when ratios were ≥ 15 to determine if inflammation was supported. Very good agreement (86%) was found on the presence of inflammation when PP:F ratios were compared to fibrinogen concentration. In 72% of cases in which PP:F ratios did not support inflammation, inflammation was considered likely based on albumin and total protein. These findings suggest that PP:F ratios do not provide additional information in horses over fibrinogen concentrations alone. Le ratio plasma protéine: fibrinogène (PP:F) a été introduit pour aider à l’interprétation de l’hyperfibrinogénémie lors d’hémoconcentration. Toutefois, la valeur clinique de ce ratio est inconnue. Notre objectif était de déterminer si le ratio amène une information additionnelle comparé au fibrinogène. Deux bases de données ont été revues pour identifier 412 chevaux hyperfibrinogénémiques. Le ratio a été calculé et son interprétation comparée à celle du fibrinogène. Les ratios < 15 suggèrent l’inflammation. Pour les cas présentant un ratio ≥ 15, la concentration en albumine et protéines totales a été revue pour voir si l’inflammation était possible. Nos résultats indiquent que dans 86 % des cas, le ratio et le fibrinogène suggèrent la présence d’inflammation. Pour 72 % des cas où le ratio ne suggère pas l’inflammation, cette dernière est considérée probable étant donné la concentration en protéines totales et albumine. Ces résultats suggèrent que le ratio PP:F n’apporte pas d’information supplémentaire comparé au fibrinogène.(Traduit par les auteurs).
Get Full Text
Publication Date: 2019-06-04 PubMed ID: 31156263PubMed Central: PMC6515800
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores whether the plasma protein:fibrinogen ratio in horses imparts additional data beyond fibrinogen concentration alone. The study found that this ratio generally doesn’t provide any extra information beyond fibrinogen concentrations.

Research Objective

  • The primary goal of this research was to discern if the plasma protein:fibrinogen (PP:F) ratio offers more information than the fibrinogen concentration alone in adult horses. This ratio is typically utilized to interpret hyperfibrinogenemia, a condition characterized by elevated levels of fibrinogen in the blood, in conjunction with dehydration. The clinical relevance of the PP:F ratio, however, remains unknown.

Methods Used

  • Two databases were reviewed to identify 412 hyperfibrinogenemic horses. PP:F ratios were calculated and their interpretation compared to the fibrinogen concentration.
  • If the PP:F ratio was less than 15, it was generally assumed to indicate inflammation. However, when the ratio was equal to or above 15, the albumin and total protein concentrations were further analyzed to determine the likelihood of inflammation.

Findings

  • When comparing the PP:F ratios with fibrinogen concentration, 86% agreement was identified in diagnosing the presence of inflammation.
  • In instances where the PP:F ratios did not support the presence of inflammation (around 72% of cases), inflammation was still deemed likely based on observations of the total albumin and protein concentrations.
  • Ultimately, it was concluded that the PP:F ratios do not generally provide additional information in horses beyond the simple measurements of fibrinogen concentrations.

Cite This Article

APA
Fernandez NJ, Roy MF. (2019). Do plasma protein:fibrinogen ratios in horses provide additional information compared with fibrinogen concentration alone? Can Vet J, 60(6), 625-629.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 60
Issue: 6
Pages: 625-629

Researcher Affiliations

Fernandez, Nicole J
  • Department of Veterinary Pathology, Western College of Veterinary Medicine, 1642-52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Fernandez); Veterinary Clinical and Diagnostic Sciences, University of Calgary Faculty of Veterinary Medicine, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Roy).
Roy, Marie-France
  • Department of Veterinary Pathology, Western College of Veterinary Medicine, 1642-52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Fernandez); Veterinary Clinical and Diagnostic Sciences, University of Calgary Faculty of Veterinary Medicine, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Roy).

MeSH Terms

  • Animals
  • Biomarkers
  • Fibrinogen / analysis
  • Horse Diseases
  • Horses
  • Inflammation / veterinary

References

This article includes 20 references
  1. Mackie IJ, Kitchen S, Machin SJ, Lowe GD. Guidelines on fibrinogen assays.. Br J Haematol 2003 May;121(3):396-404.
    pubmed: 12716361doi: 10.1046/j.1365-2141.2003.04256.xgoogle scholar: lookup
  2. Crisman MV, Scarratt WK, Zimmerman KL. Blood proteins and inflammation in the horse.. Vet Clin North Am Equine Pract 2008 Aug;24(2):285-97, vi.
    pubmed: 18652956doi: 10.1016/j.cveq.2008.03.004google scholar: lookup
  3. Schalm OW, Smith R, Kaneko JJ. Plasma protein:fibrinogen ratios in dogs, cattle and horses. Part 1. Influence of age on normal values and explanation of use in disease.. California Vet 1970 Feb;:9–11.
  4. Schalm OW. Plasma protein:fibrinogen ratios in disease in the dog and horse — Part II.. California Vet 1970 Apr;:19–22.
  5. Stockham SL, Scott MA. Fundamentals of Veterinary Clinical Pathology. .
  6. Wallace K. Proteins. .
  7. Thrall MA, Weiser G, Allison R, Campbell T. Veterinary Hematology and Clinical Chemistry. .
  8. Latimer KS. Duncan and Prasse’s Veterinary Laboratory Medicine: Clinical Pathology. .
  9. Feldman BF, Joseph GZ, Jain NC. Schalm’s Veterinary Hematology. .
  10. Hodgson J. Protein, hyperfibrinogenemia. .
  11. eClinPathcom Online Textbook. Cornell University; [Last accessed April 9, 2019]. Available from: http://www.eclinpath.com/hemostasis/tests/fibrinogen/
  12. Reed SM, Bayly WM, Sellon DC. Equine Internal Medicine. .
  13. Smith BP. Large Animal Internal Medicine. .
  14. Constable PD, Hinchcliff KW, Done SH, Grünberg W. Veterinary Medicine. .
  15. Schalm OW. Equine hematology. III. Significance of plasma fibrinogen concentration in clinical disorders in horses.. Equine Pract 1979;1:22–28.
  16. Campbell MD, Bellamy JE, Searcy GP. Determination of plasma fibrinogen concentration in the horse.. Am J Vet Res 1981 Jan;42(1):100-4.
    pubmed: 7224302
  17. Roy MF, Kwong GP, Lambert J, Massie S, Lockhart S. Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome.. J Vet Intern Med 2017 Mar;31(2):582-592.
    pmc: PMC5354005pubmed: 28207163doi: 10.1111/jvim.14670google scholar: lookup
  18. Schalm OW. Plasma protein:fibrinogen ratios in routine clinical material from cats, dogs, horses, and cattle — Part III.. California Vet 1970 Jun;:6–10.
  19. Andrews DA, Reagan WJ, DeNicola DB. Plasma-fibrinogen in recognizing equine inflammatory disease.. Compend Contin Educ Pract Vet 1994;16:1349–1356.
  20. Belgrave RL, Dickey MM, Arheart KL, Cray C. Assessment of serum amyloid A testing of horses and its clinical application in a specialized equine practice.. J Am Vet Med Assoc 2013 Jul 1;243(1):113-9.
    pubmed: 23786199doi: 10.2460/javma.243.1.113google scholar: lookup

Citations

This article has been cited 1 times.
  1. Arifianto D, Esfandiari A, Wibawan IWT, Amrozi A, Maharani M, Darsono D, Setiadi H, Setiyono A. Assessment of health impacts in retired antisera-producing horses: Blood biochemistry and serum amyloid A analysis. Vet World 2024 Sep;17(9):2136-2143.
    doi: 10.14202/vetworld.2024.2136-2143pubmed: 39507779google scholar: lookup
Subscribe to our newsletter
Join 99,850 horse owners like you who receive our email updates on horse health and nutrition.