Does Intravenous Ondansetron Affect the Intestinal Motility Pattern in Healthy Donkeys (Equus asinus)?
Abstract: The current study was undertaken to investigate the effect of intravenous administration of ondansetron on the small and large intestinal motility in donkeys (Equus asinus) using non-invasive transabdominal ultrasonography. The current prospective, randomized, placebo-controlled, crossover study was conducted on thirty healthy donkeys (15 males and 15 females). The selected donkeys underwent two trials; the first was performed by intravenous administration of saline solution as a placebo, while the second was carried out by intravenous administration of ondansetron hydrochloride. The contractility of selected portions of both the small intestine (duodenum and jejunum) and the large intestine (left colon, right colon, and cecum) was counted over a period of 3 minutes before administration (zero time) and at 15, 30, 60, 90, 120, 180, and 240 minutes after administration. The results of this study showed that ondansetron significantly altered the small and large intestinal contractility compared to normal saline. Intravenous administration of ondansetron induced a significant decrease in the duodenal, jejunal and cecal contractility compared to placebo at 30, 60, 90, and 120 minutes after administration. Likewise, ondansetron induced a significant decrease in the left colon and right colon contractility when compared with placebo at 30, 60, 90, 120, and 180 minutes following administration. Ondansetron can be used as a highly specific and selective serotonin 5-HT receptor antagonist for reducing the small and large intestinal motility in donkeys, and is therefore highly suggested for treating spasmodic colic in equine.
Copyright © 2021. Published by Elsevier Inc.
Publication Date: 2021-02-25 PubMed ID: 33993949DOI: 10.1016/j.jevs.2021.103427Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Randomized Controlled Trial
- Veterinary
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article investigates the impact of ondansetron, a type of medication, on the intestinal movements of healthy donkeys. Results revealed that the drug led to significant decreases in contractions across numerous sections of the intestine, supporting its potential use in treating spasmodic colic in equines.
Research Overview and Methodology
- The aim of this study was to examine the effects of ondansetron on small and large intestinal motility in donkeys using non-invasive transabdominal ultrasonography.
- The study was a prospective, randomized, placebo-controlled, crossover study that involved thirty healthy donkeys, gender balanced with 15 males and 15 females.
- The participating donkeys underwent two trials: they were administered saline solution (a placebo) in the first test, and then with ondansetron hydrochloride in the second.
- Contractility measurements for sections of the small (duodenum and jejunum) and large (left colon, right colon, and cecum) intestines were obtained prior to administration (zero time) and at several intervals post-administration (15, 30, 60, 90, 120, 180, and 240 minutes).
Results and Findings
- The findings indicate significant changes in the contractility of both small and large intestines when ondansetron was administered as opposed to the normal saline solution.
- Specifically, there was a noticeable reduction in duodenal, jejunal, and cecal activities between 30 and 120 minutes after ondansetron administration, compared to the placebo.
- Similarly, ondansetron administration caused significant declines in left colon and right colon contractility between 30 and 180 minutes post-administration when compared with the placebo.
Implications and Recommendations
Cite This Article
APA
Farag AMM, Ibrahim HMM.
(2021).
Does Intravenous Ondansetron Affect the Intestinal Motility Pattern in Healthy Donkeys (Equus asinus)?
J Equine Vet Sci, 101, 103427.
https://doi.org/10.1016/j.jevs.2021.103427 Publication
Researcher Affiliations
- Department of Internal Medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
- Department of Internal Medicine, Infectious and Fish Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. Electronic address: hussam-habosha@mans.edu.eg.
MeSH Terms
- Animals
- Cross-Over Studies
- Equidae
- Female
- Gastrointestinal Motility
- Horses
- Infusions, Intravenous / veterinary
- Male
- Ondansetron / pharmacology
Citations
This article has been cited 3 times.- Marzok M, Kandeel M, Alkhodair K, Abdel-Raheem S, Ismail H, Farag A, Ibrahim H, El-Ashkar M, Shousha S, El-Khodery S. Evaluation of cardiac indices using M-mode echocardiography after administration of metoclopramide and ondansetron in donkeys (Equus asinus): an experimental study. Front Vet Sci 2023;10:1189710.
- Abass M, Ibrahim H, Salci H, Hamed MA. Evaluation of the effect of different sedative doses of dexmedetomidine on the intestinal motility in clinically healthy donkeys (Equus asinus). BMC Vet Res 2022 Jul 14;18(1):274.
- Mansi S, Dorfman L, El-Chammas K, Santucci N, Graham K, Fei L, Wittkugel E, Levi S, Kaul A. Perioperative management protocol for pediatric endoluminal functional lumen imaging probe in esophageal motility disorders. J Pediatr Gastroenterol Nutr 2024 Sep;79(3):746-751.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
