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Frontiers in cellular and infection microbiology2021; 11; 622735; doi: 10.3389/fcimb.2021.622735

Dynamic Changes in Microbiome Composition Following Mare’s Milk Intake for Prevention of Collateral Antibiotic Effect.

Abstract: Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High antibiotic usage is especially common in children with developing microbiome. We hypothesized that dry Mare's milk, which is rich in biologically active substances without containing live bacteria, could be used as a prebiotic in promoting microbial diversity following antibiotic treatment in children. The present pilot study aims to determine the impacts of dry Mare's milk on the diversity of gut bacterial communities when administered during antibiotic treatment and throughout the subsequent recovery phase. Six children aged 4 to 5 years and diagnosed with bilateral bronchopneumonia were prescribed cephalosporin antibiotics. During the 60 days of the study, three children consumed dry Mare's milk whereas the other three did not. Fecal samples were collected daily during antibiotic therapy and every 5 days after antibiotic therapy. Total DNA was isolated and taxonomic composition of gut microbiota was analyzed by 16S rRNA amplicon sequencing. To assess the immune status of the gut, stool samples were analyzed by bead-based multiplex assays. Mare's milk treatment seems to prevent the bloom of Mollicutes, while preventing the loss of Coriobacteriales. Immunological analysis of the stool reveals an effect of Mare's milk on local immune parameters under the present conditions.
Copyright © 2021 Kushugulova, Löber, Akpanova, Rysbekov, Kozhakhmetov, Khassenbekova, Essex, Nurgozhina, Nurgaziyev, Babenko, Markó and Forslund.
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Publication Date: 2021-04-21 PubMed ID: 33968795PubMed Central: PMC8097163DOI: 10.3389/fcimb.2021.622735Google Scholar: Lookup
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the beneficial effects of dry mare’s milk on the diversity of gut bacteria in children undergoing antibiotic treatment. The study suggests that mare’s milk can prevent the harmful bacterial bloom while preserving the beneficial ones, hence curtailing the negative impacts of antibiotics on the gut microbiome.

Study Aim and Hypothesis

The study is a pilot test aimed to understand the impacts of dry Mare’s milk on gut bacterial diversity during antibiotic treatment and the recovery phase. The researchers hypothesized that dry Mare’s milk, a substance rich in biological nutrients but devoid of any live bacteria, could function as a prebiotic. It could promote microbial diversity in the guts of children undergoing antibiotic therapy.

Research Methodology

  • The study looked at six children aged between 4 to 5 years, each diagnosed with bilateral bronchopneumonia. They were prescribed cephalosporin antibiotics, and for the duration of the 60-day study, three of these children were given dry Mare’s milk, while the remaining three weren’t.
  • Fecal samples from these children were collected each day during antibiotic therapy, and then every five days post-therapy. Total DNA was isolated from these samples, and the composition of the gut microbiota was analyzed via 16S rRNA amplicon sequencing.
  • To ascertain the local immune status of the gut, the stool samples were scrutinized through bead-based multiplex assays.

Study Findings

Mare’s milk treatment appeared to halt the proliferation of certain harmful bacteria (Mollicutes) while preventing the loss of beneficial bacterial orders (Coriobacteriales). The research indicates that the Mare’s milk treatment impacts the local immune parameters. However, the details of these immunological effects are not explicitly explained in the abstract. Overall, the findings suggest that Mare’s milk has potential as a prebiotic in preserving and promoting gut microbial diversity during antibiotic treatment.

Cite This Article

APA
Kushugulova A, Löber U, Akpanova S, Rysbekov K, Kozhakhmetov S, Khassenbekova Z, Essex M, Nurgozhina A, Nurgaziyev M, Babenko D, Markó L, Forslund SK. (2021). Dynamic Changes in Microbiome Composition Following Mare’s Milk Intake for Prevention of Collateral Antibiotic Effect. Front Cell Infect Microbiol, 11, 622735. https://doi.org/10.3389/fcimb.2021.622735

Publication

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
NlmUniqueID: 101585359
Country: Switzerland
Language: English
Volume: 11
Pages: 622735
PII: 622735

Researcher Affiliations

Kushugulova, Almagul
  • Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.
  • Kazakhstan Society of Human Microbiome Researchers, Nur-Sultan, Kazakhstan.
  • SaumalBioTech, Nur-Sultan, Kazakhstan.
Löber, Ulrike
  • Experimental and Clinical Research Center, a Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Akpanova, Saniya
  • Department of Pediatric Diseases with Courses in Cardio-Rheumatology and Gastroenterology, Nur-sultan (Astana) Medical University, Nur-Sultan, Kazakhstan.
Rysbekov, Kairat
  • Department of Pediatric Diseases with Courses in Cardio-Rheumatology and Gastroenterology, Nur-sultan (Astana) Medical University, Nur-Sultan, Kazakhstan.
Kozhakhmetov, Samat
  • Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.
  • Kazakhstan Society of Human Microbiome Researchers, Nur-Sultan, Kazakhstan.
  • SaumalBioTech, Nur-Sultan, Kazakhstan.
Khassenbekova, Zhanagul
  • Kazakhstan Society of Human Microbiome Researchers, Nur-Sultan, Kazakhstan.
Essex, Morgan
  • Experimental and Clinical Research Center, a Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin, Berlin, Germany.
Nurgozhina, Ayaulym
  • Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.
  • Kazakhstan Society of Human Microbiome Researchers, Nur-Sultan, Kazakhstan.
Nurgaziyev, Madiyar
  • Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, Kazakhstan.
  • Kazakhstan Society of Human Microbiome Researchers, Nur-Sultan, Kazakhstan.
Babenko, Dmitriy
  • Research Center Karaganda Medical University, Karagandy, Kazakhstan.
Markó, Lajos
  • Experimental and Clinical Research Center, a Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Forslund, Sofia K
  • Experimental and Clinical Research Center, a Cooperation of Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.
  • Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
  • Structural and Computational Biology Unit, The European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

MeSH Terms

  • Animals
  • Anti-Bacterial Agents
  • Child
  • Female
  • Horses
  • Humans
  • Microbiota
  • Milk
  • Pilot Projects
  • RNA, Ribosomal, 16S / genetics

Conflict of Interest Statement

Authors AK and SK were employed by the company SaumalBioTech LLP, which activity is in the area of the scientific research of mare’s milk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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Citations

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