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Home / Equine Research Bank / Front Immunol / Early allergen introduction overrides allergy predisposition...
Frontiers in immunology2025; 16; 1654693; doi: 10.3389/fimmu.2025.1654693

Early allergen introduction overrides allergy predisposition in offspring of horses with Culicoides hypersensitivity.

Abstract: The origins of allergy are both genetic and environmental. We performed a full-sibling study to determine the role of early-in-life or delayed allergen introduction on hypersensitivity development in a cohort with history of an allergic phenotype and Culicoides hypersensitivity. IgE-mediated allergies naturally develop in many mammalian species, and we used a horse model of allergy called hypersensitivity. hypersensitivity is a seasonal, recurrent, IgE-mediated allergy caused by the salivary proteins of biting midges. Unassigned: The study included four cohorts that lived together in the same environment, only differing in the timing of allergen exposure and the transfer of allergen-specific maternal antibodies. The parent cohort was first exposed to allergens in adulthood, and each full-sibling cohort was first exposed to allergen either in puberty or at birth. All full-siblings had at least one allergic parent with an allergic phenotype, suggesting a predisposition to develop allergy. Allergen-specific IgE and IgG isotypes were measured before and after exposure to to determine whether maternal-acquired allergen-specific antibodies influenced the rate of hypersensitivity development. All four cohorts were followed for at least nine years of allergen exposure. Unassigned: The rate of allergy development was inversely related to the timing of allergen exposure where introduction in adulthood led to the highest rate of allergy development (62.5%), a moderate allergy rate was found for introduction during adolescence (21.4%), and no individuals exposed at birth developed hypersensitivity. In addition, exposure to maternally-acquired allergen-specific IgE and IgG did not influence the rate of allergy development in the cohorts exposed to allergen at birth. Unassigned: We provide strong evidence in a full-sibling study that early-in-life allergen exposure, independent of maternal allergen-specific immunoglobulin, prevents hypersensitivity development in individuals born to parents with an allergic phenotype.
Copyright © 2025 Simonin, Torsteinsdóttir, Svansson, Björnsdóttir, Freer, Tarsillo and Wagner.
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Publication Date: 2025-10-21 PubMed ID: 41194920PubMed Central: PMC12583015DOI: 10.3389/fimmu.2025.1654693Google Scholar: Lookup
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APA
Simonin EM, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Freer H, Tarsillo J, Wagner B. (2025). Early allergen introduction overrides allergy predisposition in offspring of horses with Culicoides hypersensitivity. Front Immunol, 16, 1654693. https://doi.org/10.3389/fimmu.2025.1654693

Publication

Frontiers in immunology
ISSN: 1664-3224
NlmUniqueID: 101560960
Country: Switzerland
Language: English
Volume: 16
Pages: 1654693
PII: 1654693

Researcher Affiliations

Simonin, Elisabeth M
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Torsteinsdóttir, Sigurbjorg
  • The Institute for Experimental Pathology, at Keldur, University of Iceland, Reykjavik, Iceland.
Svansson, Vilhjálmur
  • The Institute for Experimental Pathology, at Keldur, University of Iceland, Reykjavik, Iceland.
Björnsdóttir, Sigríður
  • Office of Animal Health and Welfare, Icelandic Food, and Veterinary Authority, MAST (MAST), Selfoss, Iceland.
Freer, Heather
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Tarsillo, Justine
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Wagner, Bettina
  • Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.

MeSH Terms

  • Animals
  • Ceratopogonidae / immunology
  • Horses / immunology
  • Allergens / immunology
  • Female
  • Immunoglobulin E / immunology
  • Immunoglobulin E / blood
  • Hypersensitivity / immunology
  • Hypersensitivity / veterinary
  • Male
  • Horse Diseases / immunology
  • Immunoglobulin G / immunology
  • Immunoglobulin G / blood
  • Insect Proteins / immunology
  • Disease Susceptibility
  • Immunity, Maternally-Acquired

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

This article includes 71 references
  1. Pyrhönen K, Hiltunen L, Kaila M, Näyhä S, Läärä E. Heredity of food allergies in an unselected child population: an epidemiological survey from Finland. Pediatr Allergy Immunol. (2011) 22:e124–132. doi:  10.1111/j.1399-3038.2010.01095.x, PMID:
    doi: 10.1111/j.1399-3038.2010.01095.xpubmed: 20961338google scholar: lookup
  2. Johansson E, Mersha TB. Genetics of food allergy. Immunol Allergy Clin North Am. (2021) 41:301–19. doi:  10.1016/j.iac.2021.01.010, PMID:
    doi: 10.1016/j.iac.2021.01.010pmc: PMC8053212pubmed: 33863485google scholar: lookup
  3. Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai H-J, Liu X, et al. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. (2015) 6:6304. doi:  10.1038/ncomms7304, PMID:
    doi: 10.1038/ncomms7304pmc: PMC4340086pubmed: 25710614google scholar: lookup
  4. Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, et al. The MALT1 locus and peanut avoidance in the risk for peanut allergy. J Allergy Clin Immunol. (2019) 143:2326–9. doi:  10.1016/j.jaci.2019.02.016, PMID:
    doi: 10.1016/j.jaci.2019.02.016pmc: PMC6556406pubmed: 30825465google scholar: lookup
  5. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. (2015) 372:803–13. doi:  10.1056/NEJMoa1414850, PMID:
    doi: 10.1056/NEJMoa1414850pmc: PMC4416404pubmed: 25705822google scholar: lookup
  6. Tsai H-J, Kumar R, Pongracic J, Liu X, Story R, Yu Y, et al. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy. (2009) 39:101–9. doi:  10.1111/j.1365-2222.2008.03111.x, PMID:
    doi: 10.1111/j.1365-2222.2008.03111.xpmc: PMC2729087pubmed: 19016802google scholar: lookup
  7. Keet C, Pistiner M, Plesa M, Szelag D, Shreffler W, Wood R, et al. Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy. J Allergy Clin Immunol. (2021) 147:984–991.e5. doi:  10.1016/j.jaci.2020.11.033, PMID:
    doi: 10.1016/j.jaci.2020.11.033pmc: PMC8462937pubmed: 33483153google scholar: lookup
  8. Wei-Liang Tan J, Valerio C, Barnes EH, Turner PJ, Van Asperen PA, Kakakios AM, et al. A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy. J Allergy Clin Immunol. (2017) 139:1621–1628.e8. doi:  10.1016/j.jaci.2016.08.035, PMID:
    doi: 10.1016/j.jaci.2016.08.035pubmed: 27742394google scholar: lookup
  9. Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, et al. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet. (2017) 389:276–86. doi:  10.1016/S0140-6736(16)31418-0, PMID:
    doi: 10.1016/S0140-6736(16)31418-0pubmed: 27939035google scholar: lookup
  10. Bellach J, Schwarz V, Ahrens B, Trendelenburg V, Aksünger Ö, Kalb B, et al. Randomized placebo-controlled trial of hen’s egg consumption for primary prevention in infants. J Allergy Clin Immunol. (2017) 139:1591–1599.e2. doi:  10.1016/j.jaci.2016.06.045, PMID:
    doi: 10.1016/j.jaci.2016.06.045pubmed: 27523961google scholar: lookup
  11. Palmer DJ, Sullivan TR, Gold MS, Prescott SL, Makrides M. Randomized controlled trial of early regular egg intake to prevent egg allergy. J Allergy Clin Immunol. (2017) 139:1600–1607.e2. doi:  10.1016/j.jaci.2016.06.052, PMID:
    doi: 10.1016/j.jaci.2016.06.052pubmed: 27554812google scholar: lookup
  12. Schaffartzik A, Hamza E, Janda J, Crameri R, Marti E, Rhyner C. Equine insect bite hypersensitivity: what do we know? Vet Immunol Immunopathol. (2012) 147:113–26. doi:  10.1016/j.vetimm.2012.03.017, PMID:
    doi: 10.1016/j.vetimm.2012.03.017pubmed: 22575371google scholar: lookup
  13. Larson EM, Wagner B. Viral infection and allergy – What equine immune responses can tell us about disease severity and protection. Mol Immunol. (2021) 135:329–41. doi:  10.1016/j.molimm.2021.04.013, PMID:
    doi: 10.1016/j.molimm.2021.04.013pubmed: 33975251google scholar: lookup
  14. Wagner B, Miller WH, Erb HN, Lunn DP, Antczak DF. Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses. Vet Immunol Immunopathol. (2009) 132:53–61. doi:  10.1016/j.vetimm.2009.09.015, PMID:
    doi: 10.1016/j.vetimm.2009.09.015pubmed: 19836083google scholar: lookup
  15. Novotny EN, White SJ, Wilson AD, Stefánsdóttir SB, Tijhaar E, Jonsdóttir S, et al. Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity. Allergy. (2021) 76:1147–57. doi:  10.1111/all.14556, PMID:
    doi: 10.1111/all.14556pmc: PMC8246938pubmed: 32780483google scholar: lookup
  16. Raza F, Ivanek R, Freer H, Reiche D, Rose H, Torsteinsdóttir S, et al. Cul o 2 specific IgG3/5 antibodies predicted Culicoides hypersensitivity in a group imported Icelandic horses. BMC Vet Res. (2020) 16:283. doi:  10.1186/s12917-020-02499-w, PMID:
    doi: 10.1186/s12917-020-02499-wpmc: PMC7418374pubmed: 32778104google scholar: lookup
  17. Wagner B, Childs BA, Erb HN. A histamine release assay to identify sensitization to Culicoides allergens in horses with skin hypersensitivity. Vet Immunol Immunopathol. (2008) 126:302–8. doi:  10.1016/j.vetimm.2008.09.001, PMID:
    doi: 10.1016/j.vetimm.2008.09.001pubmed: 18926574google scholar: lookup
  18. Horohov DW. The equine immune responses to infectious and allergic disease: a model for humans? Mol Immunol. (2015) 66:89–96. doi:  10.1016/j.molimm.2014.09.020, PMID:
    doi: 10.1016/j.molimm.2014.09.020pubmed: 25457878google scholar: lookup
  19. Wagner B, Miller WH, Morgan EE, Hillegas JM, Erb HN, Leibold W, et al. IgE and IgG antibodies in skin allergy of the horse. Vet Res. (2006) 37:813–25. doi:  10.1051/vetres:2006039, PMID:
    doi: 10.1051/vetres:2006039pubmed: 16973120google scholar: lookup
  20. Andersson LS, Swinburne JE, Meadows JRS, Broström H, Eriksson S, Fikse WF, et al. The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations. Immunogenetics. (2012) 64:201–8. doi:  10.1007/s00251-011-0573-1, PMID:
    doi: 10.1007/s00251-011-0573-1pmc: PMC3276761pubmed: 21947540google scholar: lookup
  21. Klumplerova M, Vychodilova L, Bobrova O, Cvanova M, Futas J, Janova E, et al. Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses. Mol Biol Rep. (2013) 40:3333–40. doi:  10.1007/s11033-012-2408-z, PMID:
    doi: 10.1007/s11033-012-2408-zpubmed: 23275235google scholar: lookup
  22. Anderson GS, Belton P, Kleider N. Hypersensitivity of horses in British Columbia to extracts of native and exotic species of Culicoides (Diptera: Ceratopogonidae). J Med Entomol. (1993) 30:657–63. doi:  10.1093/jmedent/30.4.657, PMID:
    doi: 10.1093/jmedent/30.4.657pubmed: 8360890google scholar: lookup
  23. Braverman Y. Preferred landing sites of Culicoides species (Diptera: Ceratopogonidae) on a horse in Israel and its relevance to summer seasonal recurrent dermatitis (sweet itch). Equine Vet J. (1988) 20:426–9. doi:  10.1111/j.2042-3306.1988.tb01566.x, PMID:
    doi: 10.1111/j.2042-3306.1988.tb01566.xpubmed: 3215168google scholar: lookup
  24. Greiner EC, Fadok VA, Rabin EB. Equine Culicoides hypersensitivity in Florida: biting midges aspirated from horses. Med Vet Entomol. (1990) 4:375–81. doi:  10.1111/j.1365-2915.1990.tb00454.x, PMID:
    doi: 10.1111/j.1365-2915.1990.tb00454.xpubmed: 2133005google scholar: lookup
  25. Larsen HJ, Bakke SH, Mehl R. Intradermal challenge of Icelandic horses in Norway and Iceland with extracts of Culicoides spp. Acta Vet Scand. (1988) 29:311–4. doi:  10.1186/BF03548623, PMID:
    doi: 10.1186/BF03548623pmc: PMC8161629pubmed: 3256230google scholar: lookup
  26. Miller JE, Mann S, Fettelschoss-Gabriel A, Wagner B. Comparison of three clinical scoring systems for Culicoides hypersensitivity in a herd of Icelandic horses. Vet Dermatol. (2019) 30:536–e163. doi:  10.1111/vde.12784, PMID:
    doi: 10.1111/vde.12784pubmed: 31441172google scholar: lookup
  27. Schaffartzik A, Marti E, Crameri R, Rhyner C. Cloning, production and characterization of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity. Vet Immunol Immunopathol. (2010) 137:76–83. doi:  10.1016/j.vetimm.2010.04.012, PMID:
    doi: 10.1016/j.vetimm.2010.04.012pubmed: 20537727google scholar: lookup
  28. Schaffartzik A, Marti E, Torsteinsdottir S, Mellor PS, Crameri R, Rhyner C. Selective cloning, characterization, and production of the Culicoides nubeculosus salivary gland allergen repertoire associated with equine insect bite hypersensitivity. Vet Immunol Immunopathol. (2011) 139:200–9. doi:  10.1016/j.vetimm.2010.10.015, PMID:
    doi: 10.1016/j.vetimm.2010.10.015pubmed: 21071100google scholar: lookup
  29. Steinman A, Peer G, Klement E. Epidemiological study of Culicoides hypersensitivity in horses in Israel. Vet Rec. (2003) 152:748–51. doi:  10.1136/vr.152.24.748, PMID:
    doi: 10.1136/vr.152.24.748pubmed: 12833935google scholar: lookup
  30. van der Meide NMA, Roders N, Sloet van Oldruitenborgh-Oosterbaan MM, Schaap PJ, van Oers MM, Leibold W, et al. Cloning and expression of candidate allergens from Culicoides obsoletus for diagnosis of insect bite hypersensitivity in horses. . Vet Immunol Immunopathol. (2013) 153:227–39. doi:  10.1016/j.vetimm.2013.03.005, PMID:
    doi: 10.1016/j.vetimm.2013.03.005pubmed: 23561552google scholar: lookup
  31. Björnsdóttir S, Sigvaldadóttir J, Broström H, Langvad B, Sigurdsson A. Summer eczema in exported Icelandic horses: influence of environmental and genetic factors. Acta Vet Scand. (2006) 48:3. doi:  10.1186/1751-0147-48-3, PMID:
    doi: 10.1186/1751-0147-48-3pmc: PMC1513129pubmed: 16987399google scholar: lookup
  32. Sommer-Locher B, Endriss V, Fromm E. Various circumstances regarding initial allergen exposure and their influence on development of insect bite hypersensitivity in horses. J Equine Veterinary Sci. (2012) 32:158–63. doi:  10.1016/j.jevs.2011.08.013
    doi: 10.1016/j.jevs.2011.08.013google scholar: lookup
  33. Torsteinsdottir S, Scheidegger S, Baselgia S, Jonsdottir S, Svansson V, Björnsdottir S, et al. A prospective study on insect bite hypersensitivity in horses exported from Iceland into Switzerland. Acta Vet Scand. (2018) 60:69. doi:  10.1186/s13028-018-0425-1, PMID:
    doi: 10.1186/s13028-018-0425-1pmc: PMC6215642pubmed: 30390694google scholar: lookup
  34. Halldórdsóttir S, Larsen HJ. An epidemiological study of summer eczema in Icelandic horses in Norway. Equine Vet J. (1991) 23:296–9. doi:  10.1111/j.2042-3306.1991.tb03721.x, PMID:
    doi: 10.1111/j.2042-3306.1991.tb03721.xpubmed: 1915231google scholar: lookup
  35. Bundhoo A, Paveglio S, Rafti E, Dhongade A, Blumberg RS, Matson AP. Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes. Clin Exp Allergy. (2015) 45:1085–98. doi:  10.1111/cea.12508, PMID:
    doi: 10.1111/cea.12508pmc: PMC4437844pubmed: 25652137google scholar: lookup
  36. Wagner B, Flaminio JBF, Hillegas J, Leibold W, Erb HN, Antczak DF. Occurrence of IgE in foals: evidence for transfer of maternal IgE by the colostrum and late onset of endogenous IgE production in the horse. Vet Immunol Immunopathol. (2006) 110:269–78. doi:  10.1016/j.vetimm.2005.10.007, PMID:
    doi: 10.1016/j.vetimm.2005.10.007pubmed: 16343646google scholar: lookup
  37. Holmes CM, Violette N, Miller D, Wagner B, Svansson V, Antczak DF. MHC haplotype diversity in Icelandic horses determined by polymorphic microsatellites. Genes Immun. (2019) 20:660–70. doi:  10.1038/s41435-019-0075-y, PMID:
    doi: 10.1038/s41435-019-0075-ypubmed: 31068686google scholar: lookup
  38. Wagner B, Radbruch A, Rohwer J, Leibold W. Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE. Vet Immunol Immunopathol. (2003) 92:45–60. doi:  10.1016/s0165-2427(03)00007-2, PMID:
    doi: 10.1016/s0165-2427(03)00007-2pubmed: 12628763google scholar: lookup
  39. Wagner B. Monoclonal antibody development advances immunological research in horses. Veterinary Immunol Immunopathol. (2024) 272:110771. doi:  10.1016/j.vetimm.2024.110771, PMID:
    doi: 10.1016/j.vetimm.2024.110771pubmed: 38729028google scholar: lookup
  40. Wagner B, Freer H. Development of a bead-based multiplex assay for simultaneous quantification of cytokines in horses. Vet Immunol Immunopathol. (2009) 127:242–8. doi:  10.1016/j.vetimm.2008.10.313, PMID:
    doi: 10.1016/j.vetimm.2008.10.313pubmed: 19027964google scholar: lookup
  41. Sheoran AS, Lunn DP, Holmes MA. Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet Immunol Immunopathol. (1998) 62:153–65. doi:  10.1016/s0165-2427(97)00162-1, PMID:
    doi: 10.1016/s0165-2427(97)00162-1pubmed: 9638859google scholar: lookup
  42. Keggan A, Freer H, Rollins A, Wagner B. Production of seven monoclonal equine immunoglobulins isotyped by multiplex analysis. Vet Immunol Immunopathol. (2013) 153:187–93. doi:  10.1016/j.vetimm.2013.02.010, PMID:
    doi: 10.1016/j.vetimm.2013.02.010pmc: PMC10958203pubmed: 23541920google scholar: lookup
  43. Wagner B, Miller DC, Lear TL, Antczak DF. The complete map of the ig heavy chain constant gene region reveals evidence for seven igG isotypes and for igD in the horse12. J Immunol. (2004) 173:3230–42. doi:  10.4049/jimmunol.173.5.3230, PMID:
    doi: 10.4049/jimmunol.173.5.3230pubmed: 15322185google scholar: lookup
  44. Ziegler A, Hamza E, Jonsdottir S, Rhyner C, Wagner B, Schüpbach G, et al. Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Veterinary Dermatol. (2018) 29:51–e22. doi:  10.1111/vde.12493, PMID:
    doi: 10.1111/vde.12493pubmed: 28980353google scholar: lookup
  45. Perkins GA, Wagner B. The development of equine immunity: Current knowledge on immunology in the young horse. Equine Veterinary J. (2015) 47:267–74. doi:  10.1111/evj.12387, PMID:
    doi: 10.1111/evj.12387pubmed: 25405920google scholar: lookup
  46. Huffaker MF, Kanchan K, Bahnson HT, Baloh C, Lack G, Nepom GT, et al. Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial. J Allergy Clin Immunol. (2023) 151:841–7. doi:  10.1016/j.jaci.2022.12.819, PMID:
    doi: 10.1016/j.jaci.2022.12.819pmc: PMC12576930pubmed: 36732171google scholar: lookup
  47. Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med. (2012) 18:693–704. doi:  10.1038/nm.2755, PMID:
    doi: 10.1038/nm.2755pmc: PMC3597223pubmed: 22561833google scholar: lookup
  48. Järvinen KM, Fleischer DM. Can we prevent food allergy by manipulating the timing of food exposure? Immunol Allergy Clin North Am. (2012) 32:51–65. doi:  10.1016/j.iac.2011.11.007, PMID:
    doi: 10.1016/j.iac.2011.11.007pubmed: 22244232google scholar: lookup
  49. Davis EC, Jackson CM, Ting T, Harizaj A, Järvinen KM. Predictors and biomarkers of food allergy and sensitization in early childhood. Ann Allergy Asthma Immunol. (2022) 129:292–300. doi:  10.1016/j.anai.2022.04.025, PMID:
    doi: 10.1016/j.anai.2022.04.025pmc: PMC11910167pubmed: 35490857google scholar: lookup
  50. Cardenas A, Fadadu RP, Koppelman GH. Epigenome-wide association studies of allergic disease and the environment. J Allergy Clin Immunol. (2023) 152:582–90. doi:  10.1016/j.jaci.2023.05.020, PMID:
    doi: 10.1016/j.jaci.2023.05.020pmc: PMC10564109pubmed: 37295475google scholar: lookup
  51. Neeland MR, Martino DJ, Allen KJ. The role of gene-environment interactions in the development of food allergy. Expert Rev Gastroenterol Hepatol. (2015) 9:1371–8. doi:  10.1586/17474124.2015.1084873, PMID:
    doi: 10.1586/17474124.2015.1084873pubmed: 26357960google scholar: lookup
  52. Childs CE, Munblit D, Ulfman L, Gómez-Gallego C, Lehtoranta L, Recker T, et al. Potential biomarkers, risk factors and their associations with igE-mediated food allergy in early life: A narrative review. Adv Nutr. (2021) 13:633–51. doi:  10.1093/advances/nmab122, PMID:
    doi: 10.1093/advances/nmab122pmc: PMC8970818pubmed: 34596662google scholar: lookup
  53. Martino D, Dang T, Sexton-Oates A, Prescott S, Tang MLK, Dharmage S, et al. Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants. J Allergy Clin Immunol. (2015) 135:1319–1328.e1–12. doi:  10.1016/j.jaci.2014.12.1933, PMID:
    doi: 10.1016/j.jaci.2014.12.1933pubmed: 25678091google scholar: lookup
  54. Martino D, Neeland M, Dang T, Cobb J, Ellis J, Barnett A, et al. Epigenetic dysregulation of naive CD4+ T-cell activation genes in childhood food allergy. Nat Commun. (2018) 9:3308. doi:  10.1038/s41467-018-05608-4, PMID:
    doi: 10.1038/s41467-018-05608-4pmc: PMC6098117pubmed: 30120223google scholar: lookup
  55. Davenport MP, Smith NL, Rudd BD. Building a T cell compartment: how immune cell development shapes function. Nat Rev Immunol. (2020) 20:499. doi:  10.1038/s41577-020-0332-3, PMID:
    doi: 10.1038/s41577-020-0332-3pmc: PMC7390700pubmed: 32493982google scholar: lookup
  56. Kanchan K, Grinek S, Bahnson HT, Ruczinski I, Shankar G, Larson D, et al. HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy. J Clin Invest. (2022) 132:e152070. doi:  10.1172/JCI152070, PMID:
    doi: 10.1172/JCI152070pmc: PMC8718139pubmed: 34981778google scholar: lookup
  57. Neeland MR, Andorf S, Manohar M, Dunham D, Lyu S-C, Dang TD, et al. Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life. Nat Commun. (2020) 11:1091. doi:  10.1038/s41467-020-14919-4, PMID:
    doi: 10.1038/s41467-020-14919-4pmc: PMC7046671pubmed: 32107388google scholar: lookup
  58. Aoki T, Chiba A, Itoh M, Nambo Y, Yamagishi N, Shibano K, et al. Colostral and foal serum immunoglobulin G levels and associations with perinatal abnormalities in heavy draft horses in Japan. J Equine Sci. (2020) 31:29. doi:  10.1294/jes.31.29, PMID:
    doi: 10.1294/jes.31.29pmc: PMC7316699pubmed: 32617073google scholar: lookup
  59. Neeland MR, Novakovic B, Dang TD, Perrett KP, Koplin JJ, Saffery R. Hyper-inflammatory monocyte activation following endotoxin exposure in food allergic infants. Front Immunol. (2020) 11:567981. doi:  10.3389/fimmu.2020.567981, PMID:
    doi: 10.3389/fimmu.2020.567981pmc: PMC7541825pubmed: 33072108google scholar: lookup
  60. Balla J, Rathore APS, St. John AL. Maternal igE influence on fetal and infant health. Immunol Rev. (2025) 331:e70029. doi:  10.1111/imr.70029, PMID:
    doi: 10.1111/imr.70029pmc: PMC12032057pubmed: 40281548google scholar: lookup
  61. Bigler NA, Bruckmaier RM, Gross JJ. Implications of placentation type on species-specific colostrum properties in mammals. J Anim Sci. (2022) 100:skac287. doi:  10.1093/jas/skac287, PMID:
    doi: 10.1093/jas/skac287pmc: PMC9713508pubmed: 36048628google scholar: lookup
  62. Wagner B, Perkins G, Babasyan S, Freer H, Keggan A, Goodman LB, et al. Neonatal Immunization with a Single IL-4/Antigen Dose Induces Increased Antibody Responses after Challenge Infection with Equine Herpesvirus Type 1 (EHV-1) at Weanling Age. PloS One. (2017) 12:e0169072. doi:  10.1371/journal.pone.0169072, PMID:
    doi: 10.1371/journal.pone.0169072pmc: PMC5207648pubmed: 28045974google scholar: lookup
  63. Simonin E, Babasyan S, Wagner B. Peripheral CD23hi/igE+ Plasmablasts secrete igE and correlate with allergic disease severity. J Immunol (Baltimore Md : 1950). (2022) 209:665–74. doi:  10.4049/jimmunol.2101081, PMID:
    doi: 10.4049/jimmunol.2101081pubmed: 35896336google scholar: lookup
  64. Simonin E, Babasyan S, Tarsillo J, Wagner B. IgE+ plasmablasts predict the onset of clinical allergy. Front Immunol. (2023) 14:1104609. doi:  10.3389/fimmu.2023.1104609, PMID:
    doi: 10.3389/fimmu.2023.1104609pmc: PMC9932261pubmed: 36817463google scholar: lookup
  65. Croote D, Darmanis S, Nadeau KC, Quake SR. High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes. Science. (2018) 362:1306–9. doi:  10.1126/science.aau2599, PMID:
    doi: 10.1126/science.aau2599pubmed: 30545888google scholar: lookup
  66. Schnabel CL, Wimer CL, Perkins G, Babasyan S, Freer H, Watts C, et al. Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity. BMC Vet Res. (2018) 14:245. doi:  10.1186/s12917-018-1563-4, PMID:
    doi: 10.1186/s12917-018-1563-4pmc: PMC6106926pubmed: 30134896google scholar: lookup
  67. Perkin MR, Logan K, Marrs T, Radulovic S, Craven J, Flohr C, et al. Enquiring about Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen. J Allergy Clin Immunol. (2016) 137:1477–1486.e8. doi:  10.1016/j.jaci.2015.12.1322, PMID:
    doi: 10.1016/j.jaci.2015.12.1322pmc: PMC4852987pubmed: 26896232google scholar: lookup
  68. Järvinen KM, Martin H, Oyoshi MK. Immunomodulatory effects of breast milk on food allergy. Ann Allergy Asthma Immunol. (2019) 123:133–43. doi:  10.1016/j.anai.2019.04.022, PMID:
    doi: 10.1016/j.anai.2019.04.022pmc: PMC6693634pubmed: 31048004google scholar: lookup
  69. Burris AD, Pizzarello C, Järvinen KM. Immunologic components in human milk and allergic diseases with focus on food allergy. Semin Perinatol. (2021) 45:151386. doi:  10.1016/j.semperi.2020.151386, PMID:
    doi: 10.1016/j.semperi.2020.151386pubmed: 33423794google scholar: lookup
  70. Bunyavanich S, Rifas-Shiman SL, Platts-Mills TA, Workman L, Sordillo JE, Camargo CA, et al. Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children. J Allergy Clin Immunol. (2014) 133:1373–82. doi:  10.1016/j.jaci.2013.11.040, PMID:
    doi: 10.1016/j.jaci.2013.11.040pmc: PMC4004710pubmed: 24522094google scholar: lookup
  71. Sampath V, Aguilera J, Prunicki M, Nadeau KC. Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma. Semin Immunol. (2023) 67:101765. doi:  10.1016/j.smim.2023.101765, PMID:
    doi: 10.1016/j.smim.2023.101765pmc: PMC10275624pubmed: 37105834google scholar: lookup

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