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Veterinary journal (London, England : 1997)2013; 197(2); 128-142; doi: 10.1016/j.tvjl.2013.05.026

Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals.

Abstract: Over many decades assisted reproductive technologies, including artificial insemination, embryo transfer, in vitro production (IVP) of embryos, cloning by somatic cell nuclear transfer (SCNT), and stem cell culture, have been developed with the aim of refining breeding strategies for improved production and health in animal husbandry. More recently, biomedical applications of these technologies, in particular, SCNT and stem cell culture, have been pursued in domestic mammals in order to create models for human disease and therapy. The following review focuses on presenting important aspects of pre-implantation development in cattle, pigs, horses, and dogs. Biological aspects and impact of assisted reproductive technologies including IVP, SCNT, and culture of pluripotent stem cells are also addressed.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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Publication Date: 2013-06-27 PubMed ID: 23810186DOI: 10.1016/j.tvjl.2013.05.026Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper focuses on the exploration and application of assisted reproductive technologies, such as artificial insemination, embryo transfer, and stem cell culture, in the field of domestic animal breeding and biomedical applications. The researchers also delve into the impact and biological aspects of these technologies.

Overview of Early Embryonic Development in Domestic Mammals

This aspect of the research draws attention to the pre-implantation development stages in domestic animals, notably cattle, pigs, horses, and dogs. Pre-implantation development is a critical aspect of reproductive biology and the researchers place emphasis on its importance.

  • The paper describes the early developmental stages, from the fertilized egg to the development of the embryo.
  • It gives insight into the unique traits of pre-implantation development in the featured animals.

Assisted Reproductive Technologies in Animal Husbandry

The paper provides a rich detail of the assisted reproductive technologies that have been developed over the years. The focus is more on how these technologies have been employed to refine breeding strategies for improved production and health in animal husbandry.

  • The research breaks down the various assisted reproductive technologies such as artificial insemination, embryo transfer, in vitro production (IVP) of embryos, and cloning by somatic cell nuclear transfer (SCNT).
  • These technologies are explained in context of their application on the featured domestic animals – cattle, pigs, horses, and dogs.

Biomedical Applications of Assisted Reproductive Technologies

The researchers also explore the biomedical applications of these technologies. Stem cell culture and SCNT are particularly emphasized in the creation of models for human disease and therapy.

  • The paper looks at how these technologies are being used in the biomedical field, particularly in relation to creating replicable models for studying human diseases.
  • Here, the researchers project stem cell culture and SCNT as tools with immense potential to transform the biomedical field.

Impact and biological Aspects of Assisted Reproductive Technologies

Finally, the paper digs into the overall impact and the biological aspects of these reproductive technologies. It provides a critical review of its application and the possible obstacles faced.

  • It reviews the biological implications of using these technologies, noting any challenges, potential risks or ethical concerns that may arise.
  • Considerations on how best to optimize the use of these technologies for maximum results are also discussed.

In conclusion, the research paper presents a holistic insight into the use of assisted reproductive technologies in the field of domestic animal reproduction and how they can be applied in the biomedical field.

Cite This Article

APA
Hall V, Hinrichs K, Lazzari G, Betts DH, Hyttel P. (2013). Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals. Vet J, 197(2), 128-142. https://doi.org/10.1016/j.tvjl.2013.05.026

Publication

Veterinary journal (London, England : 1997)
ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 197
Issue: 2
Pages: 128-142

Researcher Affiliations

Hall, V
  • Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Denmark.
Hinrichs, K
    Lazzari, G
      Betts, D H
        Hyttel, P

          MeSH Terms

          • Animals
          • Embryo Culture Techniques / veterinary
          • Embryo, Mammalian / physiology
          • Embryonic Development
          • Pluripotent Stem Cells / physiology
          • Reproductive Techniques, Assisted / veterinary

          Citations

          This article has been cited 16 times.
          1. Choi JH, Park HJ, Yang SG, Koo DB. Paclitaxel-mediated Cytoskeletal Stabilization Improves Blastocyst Developmental Competence of Bovine Embryos in Vitro. Reprod Sci 2026 Feb 12;.
            doi: 10.1007/s43032-026-02057-zpubmed: 41680578google scholar: lookup
          2. Ardiyanto D, Wuryastuty H, Yanuartono Y, Sarmin S, Wasito R, Airin CM, Widiati DT, Mubarokah WW. Molecular identification of Brucella abortus in secondary hosts of goats and sheep in Magelang, Central Java, Indonesia. Open Vet J 2025 Nov;15(10):5658-5668.
            doi: 10.5455/OVJ.2025.v15.i11.22pubmed: 41631211google scholar: lookup
          3. de Castro RCF, Buranello TW, Recchia K, de Souza AF, Pieri NCG, Bressan FF. Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine. J Dev Biol 2024 May 7;12(2).
            doi: 10.3390/jdb12020014pubmed: 38804434google scholar: lookup
          4. Tsukamoto M, Kimura K, Yoshida T, Tanaka M, Kuwamura M, Ayabe T, Ishihara G, Watanabe K, Okada M, Iijima M, Nakanishi M, Akutsu H, Sugiura K, Hatoya S. Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors. Stem Cell Reports 2024 Jan 9;19(1):141-157.
            doi: 10.1016/j.stemcr.2023.11.010pubmed: 38134923google scholar: lookup
          5. Oh D, Choi H, Kim M, Cai L, Lee J, Jawad A, Kim S, Zheng H, Lee G, Jeon Y, Hyun SH. Interleukin-7 enhances in vitro development and blastocyst quality in porcine parthenogenetic embryos. Front Vet Sci 2022;9:1052856.
            doi: 10.3389/fvets.2022.1052856pubmed: 36570506google scholar: lookup
          6. Skrzyszowska M, Samiec M. Generating Cloned Goats by Somatic Cell Nuclear Transfer-Molecular Determinants and Application to Transgenics and Biomedicine. Int J Mol Sci 2021 Jul 13;22(14).
            doi: 10.3390/ijms22147490pubmed: 34299109google scholar: lookup
          7. Pérez-Gómez A, González-Brusi L, Bermejo-Álvarez P, Ramos-Ibeas P. Lineage Differentiation Markers as a Proxy for Embryo Viability in Farm Ungulates. Front Vet Sci 2021;8:680539.
            doi: 10.3389/fvets.2021.680539pubmed: 34212020google scholar: lookup
          8. McCoski SR, Vailes MT, Owens CE, Cockrum RR, Ealy AD. Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus. BMC Genomics 2018 Oct 11;19(1):737.
            doi: 10.1186/s12864-018-5120-0pubmed: 30305020google scholar: lookup
          9. Olivera R, Moro LN, Jordan R, Pallarols N, Guglielminetti A, Luzzani C, Miriuka SG, Vichera G. Bone marrow mesenchymal stem cells as nuclear donors improve viability and health of cloned horses. Stem Cells Cloning 2018;11:13-22.
            doi: 10.2147/SCCAA.S151763pubmed: 29497320google scholar: lookup
          10. Leite RF, Annes K, Ispada J, de Lima CB, Dos Santos ÉC, Fontes PK, Nogueira MFG, Milazzotto MP. Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on In Vitro Produced Embryos. Oxid Med Cell Longev 2017;2017:1502489.
            doi: 10.1155/2017/1502489pubmed: 29209446google scholar: lookup
          11. Ali I, Liu HX, Zhong-Shu L, Dong-Xue M, Xu L, Shah SZA, Ullah O, Nan-Zhu F. Reduced glutathione alleviates tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos. J Reprod Dev 2018 Feb 27;64(1):15-24.
            doi: 10.1262/jrd.2017-055pubmed: 29081452google scholar: lookup
          12. Ali I, Shah SZ, Jin Y, Li ZS, Ullah O, Fang NZ. Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos. J Vet Sci 2017 Mar 30;18(1):1-9.
            doi: 10.4142/jvs.2017.18.1.1pubmed: 28057903google scholar: lookup
          13. Olivera R, Moro LN, Jordan R, Luzzani C, Miriuka S, Radrizzani M, Donadeu FX, Vichera G. In Vitro and In Vivo Development of Horse Cloned Embryos Generated with iPSCs, Mesenchymal Stromal Cells and Fetal or Adult Fibroblasts as Nuclear Donors. PLoS One 2016;11(10):e0164049.
            doi: 10.1371/journal.pone.0164049pubmed: 27732616google scholar: lookup
          14. Betts DH, Tobias IC. Canine Pluripotent Stem Cells: Are They Ready for Clinical Applications?. Front Vet Sci 2015;2:41.
            doi: 10.3389/fvets.2015.00041pubmed: 26664969google scholar: lookup
          15. An R, Wang C, Turek J, Machaty Z, Nolte DD. Biodynamic imaging of live porcine oocytes, zygotes and blastocysts for viability assessment in assisted reproductive technologies. Biomed Opt Express 2015 Mar 1;6(3):963-76.
            doi: 10.1364/BOE.6.000963pubmed: 25798318google scholar: lookup
          16. Betts DH, Bain NT, Madan P. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. PLoS One 2014;9(1):e86978.
            doi: 10.1371/journal.pone.0086978pubmed: 24475205google scholar: lookup
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