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BMC veterinary research2011; 7; 23; doi: 10.1186/1746-6148-7-23

Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses.

Abstract: The purpose of this study was to compare the effects of 0.5 fraction of inspired oxygen (FiO₂) and >0.95 FiO₂ on pulmonary gas exchange, shunt fraction and oxygen delivery (DO₂) in dorsally recumbent horses during inhalant anesthesia. The use of 0.5 FiO₂ has the potential to reduce absorption atelectasis (compared to maximal FiO₂) and augment alveolar oxygen (O₂) tensions (compared to ambient air) thereby improving gas exchange and DO₂. Our hypothesis was that 0.5 FiO₂ would reduce ventilation-perfusion mismatching and increase the fraction of pulmonary blood flow that is oxygenated, thus improving arterial oxygen content and DO₂. Results: Arterial partial pressures of O₂ were significantly higher than preanesthetic levels at all times during anesthesia in the >0.95 FiO₂ group. Arterial partial pressures of O₂ did not change from preanesthetic levels in the 0.5 FiO₂ group but were significantly lower than in the >0.95 FiO₂ group from 15 to 90 min of anesthesia. Alveolar to arterial O₂ tension difference was increased significantly in both groups during anesthesia compared to preanesthetic values. The alveolar to arterial O₂ tension difference was significantly higher at all times in the >0.95 FiO₂ group compared to the 0.5 FiO2 group. Oxygen delivery did not change from preanesthetic values in either group during anesthesia but was significantly lower than preanesthetic values 10 min after anesthesia in the 0.5 FiO₂ group. Shunt fraction increased in both groups during anesthesia attaining statistical significance at varying times. Shunt fraction was significantly increased in both groups 10 min after anesthesia but was not different between groups. Alveolar dead space ventilation increased after 3 hr of anesthesia in both groups. Conclusions: Reducing FiO₂ did not change alveolar dead space ventilation or shunt fraction in dorsally recumbent, mechanically ventilated horses during 3 hr of isoflurane anesthesia. Reducing FiO₂ in dorsally recumbent isoflurane anesthetized horses does not improve oxygenation or oxygen delivery.
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Publication Date: 2011-06-03 PubMed ID: 21639886PubMed Central: PMC3133541DOI: 10.1186/1746-6148-7-23Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study aimed to understand the effect of different oxygen concentration levels, specifically 50% (0.5 FiO₂) and maximum (0.95 FiO₂), on respiration in horses under isoflurane anesthesia. However, the results revealed that reducing the inspired oxygen concentrations in anesthetized horses didn’t improve or enhance their oxygenation or oxygen delivery.

Objective of the Research

  • This research was conducted to compare the impacts of two different fractions of inspired oxygen (FiO₂) – 0.5 and >0.95 – on various respiratory parameters in horses under isoflurane anesthesia. The parameters in question include pulmonary gas exchange, the shunt fraction, and oxygen delivery (DO₂).

Hypothesis of the Study

  • The researchers hypothesized that a 0.5 FiO₂ would reduce ventilation-perfusion mismatching and increase the fraction of pulmonary blood flow that gets oxygenated. Subsequently, this would improve the arterial oxygen content and DO₂ in horses.

Findings of the Research

  • The arterial partial pressures of oxygen (O₂) were significantly higher during anesthesia in the >0.95 FiO₂ group compared to preanesthetic levels. However, there were no significant changes from preanesthetic levels in the 0.5 FiO₂ group.
  • The difference between alveolar and arterial O₂ tension increased significantly in both groups during anesthesia compared to preanesthetic values. However, this difference was consistently higher in the >0.95 FiO₂ group compared to the 0.5 FiO₂ group.
  • Shunt fraction, the amount of blood that bypasses the lungs and returns to the circulation deoxygenated, increased in both groups during anesthesia, reaching statistical significance at different times.
  • Oxygen delivery (DO₂) did not alter from preanesthetic values in either group during anesthesia but was significantly lower 10 minutes post-anesthesia in the 0.5 FiO₂ group.
  • Alveolar dead space ventilation, an area of non-functional exchange in the lung, increased after 3 hours of anesthesia in both groups.

Conclusion Derived from the Study

  • The study determined that reducing the FiO₂, in horses under isoflurane anesthesia, did not enhance alveolar dead space ventilation or the shunt fraction. Furthermore, the study concluded that reducing FiO₂ does not improve the parameters of oxygenation or oxygen delivery in dorsally recumbent (lying flat on their back) isoflurane anesthetized horses.

Cite This Article

APA
Hubbell JA, Aarnes TK, Bednarski RM, Lerche P, Muir WW. (2011). Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses. BMC Vet Res, 7, 23. https://doi.org/10.1186/1746-6148-7-23

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 7
Pages: 23

Researcher Affiliations

Hubbell, John A E
  • Deparment of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. hubbell.2@osu.edu
Aarnes, Turi K
    Bednarski, Richard M
      Lerche, Phillip
        Muir, William W

          MeSH Terms

          • Anesthesia, Inhalation / veterinary
          • Anesthetics, Inhalation
          • Animals
          • Hemodynamics / drug effects
          • Horses / physiology
          • Isoflurane
          • Oxygen / administration & dosage
          • Oxygen / blood
          • Oxygen Inhalation Therapy / veterinary
          • Partial Pressure
          • Pulmonary Gas Exchange / drug effects
          • Respiration / drug effects
          • Respiration, Artificial / veterinary

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          Citations

          This article has been cited 9 times.
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