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Equine veterinary journal2005; 37(6); 559-564; doi: 10.2746/042516405775314772

Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses.

Abstract: Lidocaine constant rate infusions (CRIs) are common as an intraoperative adjunct to general anaesthesia, but their influence on quality of recovery has not been thoroughly determined. Objective: To determine the effects of an intraoperative i.v. CRI of lidocaine on the quality of recovery from isoflurane or sevoflurane anaesthesia in horses undergoing various surgical procedures, using a modified recovery score system. Objective: The administration of intraoperative lidocaine CRI decreases the quality of recovery in horses. Methods: Lidocaine (2 mg/kg bwt bolus followed by 50 microg/kg bwt/min) or saline was administered for the duration of surgery or until 30 mins before the end of surgery under isoflurane (n = 27) and sevoflurane (n = 27). Results: Horses receiving lidocaine until the end of surgery had a significantly higher degree of ataxia and a tendency towards significance for a lower quality of recovery. There was no correlation between lidocaine plasma concentrations at recovery and the quality of recovery. Conclusions: Intraoperative CRI of lidocaine affects the degree of ataxia and may decrease the quality of recovery. Conclusions: Discontinuing lidocaine CRI 30 mins before the end of surgery is recommended to reduce ataxia during the recovery period.
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Publication Date: 2005-11-22 PubMed ID: 16295936DOI: 10.2746/042516405775314772Google Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study aimed to analyze the impact of providing a constant rate infusion (CRI) of the drug lidocaine throughout surgery on the recovery quality of horses put under both sevoflurane and isoflurane anesthesia. The study emphasized that cessation of lidocaine infusion half an hour before the surgery concludes may reduce ataxia during recovery.

Objectives and Methodology

  • The primary objective of this study was to analyze how intraoperative intravenous (i.v.) constant rate infusions (CRIs) of lidocaine influence the recovery quality of horses, which had sevoflurane or isoflurane anesthesia for various surgical procedures.
  • The unit of analysis was horses under isoflurane (n = 27) and sevoflurane (n = 27), and they were either administered lidocaine or saline for the duration of the surgery or until thirty minutes before surgery ended.
  • The administration dosage used for lidocaine was 2 milligrams/kilogram body weight as an introductory dose, followed by a perpetual rate of 50 micrograms/kilogram body weight per minute throughout the surgery.

Findings

  • The outcomes revealed that horses that were administered lidocaine up until the end of the surgery showed a higher degree of post-surgery ataxia, which is a loss of control of body movements, along with a possible decrease in recovery quality.
  • The study also found that there was no significant correlation between the lidocaine plasma concentrations at the time of recovery and the quality of the recovery experienced by the horses.

Conclusions

  • The investigators concluded that the intraoperative CRI of lidocaine could affect the degree of ataxia and somewhat lower the quality of recovery from sevoflurane and isoflurane anesthesia in horses.
  • The analysis suggests that to reduce the ataxia experienced during the recovery period, the CRI of lidocaine should be discontinued 30 minutes before the end of the surgery.

Cite This Article

APA
Valverde A, Gunkelt C, Doherty TJ, Giguère S, Pollak AS. (2005). Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses. Equine Vet J, 37(6), 559-564. https://doi.org/10.2746/042516405775314772

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 37
Issue: 6
Pages: 559-564

Researcher Affiliations

Valverde, A
  • Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA.
Gunkelt, C
    Doherty, T J
      Giguère, S
        Pollak, A S

          MeSH Terms

          • Anesthesia Recovery Period
          • Anesthesia, General / methods
          • Anesthesia, General / veterinary
          • Anesthetics, Inhalation / pharmacology
          • Anesthetics, Local / pharmacology
          • Animals
          • Heart Rate / drug effects
          • Horses / physiology
          • Infusions, Intravenous / veterinary
          • Intraoperative Care / veterinary
          • Isoflurane / pharmacology
          • Lidocaine / pharmacology
          • Methyl Ethers / pharmacology
          • Sevoflurane

          Citations

          This article has been cited 13 times.
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            doi: 10.3390/ani11092549pubmed: 34573515google scholar: lookup
          2. Vermedal H, Valverde A, Sears W. Effect of anesthesia duration on the quality of recovery in horses undergoing elective and emergency surgeries using the same anesthetic protocol. Can J Vet Res 2021 Jul;85(3):193-200.
            pubmed: 34248263
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            doi: 10.1111/evj.12958pubmed: 29679416google scholar: lookup
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            pubmed: 25565714
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            pubmed: 24688171
          9. Bauquier SH, Kona-Boun JJ. [Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses]. Can Vet J 2011 Sep;52(9):987-93.
            pubmed: 22379199
          10. Lindqvist A, Nyman G, Rydén A, Wattle O. Effect of an adjustable ceiling to prevent premature rising attempts after general anesthesia in healthy ponies and horses: A pilot study. Vet Surg 2025 Jul;54(5):851-859.
            doi: 10.1111/vsu.14181pubmed: 39887480google scholar: lookup
          11. Henderson ARP, Valverde A, Koenig J, Sears W. Effects of anesthetic protocol, procedure, and recovery stall and interval on the quality of recovery in repeatedly anesthetized horses. Can J Vet Res 2025 Jan;89(1):17-25.
            pubmed: 39744466
          12. Straticò P, Guerri G, Bandera L, Celani G, Di Nunzio L, Petrizzi L, Varasano V. Comparison of Xylazine and Lidocaine Infusion versus Medetomidine Continuous Rate Infusion during General Anesthesia with Isoflurane in Horses Undergoing Emergency Laparotomy. Vet Sci 2024 Apr 29;11(5).
            doi: 10.3390/vetsci11050196pubmed: 38787168google scholar: lookup
          13. Lambertini C, Spaccini F, Mazzanti A, Spadari A, Lanci A, Romagnoli N. Lidocaine constant rate infusion in isoflurane anesthetized neonatal foals. Front Vet Sci 2023;10:1304868.
            doi: 10.3389/fvets.2023.1304868pubmed: 38298459google scholar: lookup
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