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Effect of atropine-dobutamine stress test on left ventricular echocardiographic parameters in untrained warmblood horses.
Abstract: The aim of this study was to investigate the effect of combined atropine low-dose dobutamine stress test on left ventricular parameters in adult warmblood horses, to establish a potential protocol for pharmacological stress echocardiography. Seven healthy untrained warmblood horses aged 9 to 22 years were used. Heart rate (HR) and left ventricular B- and M-mode dimensions were recorded at baseline and during stress testing with 35 microg/kg atropine IV followed by incremental dobutamine infusion of 2 to 6 microg/kg/min. HR increased significantly (P < .05) during the pharmacological challenge, and a maximal HR of 156.6 +/- 12.5 bpm was reached at maximal dobutamine infusion rate. Systolic and diastolic interventricular septum thickness, systolic and diastolic left ventricular free wall thickness, and fractional shortening increased significantly and reached a maximum at the highest infusion rate (mean +/- SD: 4.51 +/- 0.27 versus 5.65 +/- 0.31 cm, 2.89 +/- 0.19 versus 3.78 +/- 0.10 cm, 3.72 +/- 0.34 versus 4.77 +/- 0.18 cm, 2.44 +/- 0.28 versus 3.11 +/- 0.34 cm, 34.98 +/- 3.82 versus 50.56 +/- 3.42%, respectively). Systolic and diastolic left ventricular internal diameter decreased significantly during dobutamine infusion. Left ventricular external and internal area were significantly lower at a dobutamine infusion rate of 2 microg/kg/min but no further decrease was observed during the subsequent steps. Systolic and diastolic myocardial area was significantly lower after the administration of dobutamine but not significantly different during dobutamine infusion, when compared to baseline values. This pharmacological stress test induced significant changes in left ventricular echocardiographic parameters in adult warmblood horses. Additional research should evaluate the value of this stress test in horses suffering from cardiac disease.
Publication Date: 2006-06-01 PubMed ID: 16734092DOI: 10.1892/0891-6640(2006)20[575:eoasto]2.0.co;2Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper evaluates the impact of a combined atropine low-dose dobutamine stress test on the left ventricular parameters of adult warmblood horses. The test induced significant changes in various cardiac parameters and the paper suggests further studies to analyze its value for horses with cardiac diseases.
Objective of the Research
- The primary objective of this study was to understand the impact of a combined atropine low-dose dobutamine stress test on the left ventricular parameters in adult warmblood horses. This was done with a view to establishing a possible pharmacological stress echocardiography protocol.
Methodology and Subjects
- Seven healthy untrained warmblood horses aged between 9 to 22 years were used in this study.
- The heart rate and left ventricular B- and M-mode dimensions were recorded at baseline and during the stress test which involved 35 microg/kg intravenous atropine followed by an incremental dobutamine infusion of 2 to 6 microg/kg/min.
Results and Findings
- The heart rate significantly increased during the pharmacological challenge, reaching a maximal average rate of 156.6 +/- 12.5 beats per minute at the highest dobutamine infusion rate.
- Both systolic (contracting state of the heart) and diastolic (relaxing state of the heart) measurements of the interventricular septum thickness, left ventricular free wall thickness, along with fractional shortening, also significantly increased peaking at the highest infusion rate.
- In contrast, the left ventricular internal diameter decreased significantly during dobutamine infusion.
- At a dobutamine infusion rate of 2 microg/kg/min, left ventricular external and internal area were significantly lower, but no further decrease was observed during subsequent steps. However, the systolic and diastolic myocardial area was significantly lower post the administration of dobutamine but remained statistically constant during further dobutamine infusion.
Conclusion and Further Research
- The aforementioned pharmacological stress test led to significant changes in the left ventricular echocardiographic parameters in adult warmblood horses.
- However, the study recommends additional research to assess the utility of this stress test in horses suffering from cardiac diseases.
Cite This Article
APA
Sandersen CF, Detilleux J, de Moffarts B, Van Loon G, Amory H.
(2006).
Effect of atropine-dobutamine stress test on left ventricular echocardiographic parameters in untrained warmblood horses.
J Vet Intern Med, 20(3), 575-580.
https://doi.org/10.1892/0891-6640(2006)20[575:eoasto]2.0.co;2 Publication
Researcher Affiliations
- Department of Clinical Sciences, Equine Clinics, Faculty of Veterinary Medicine, University of Liège, Belgium. charlotte.sandersen@ulg.ac.be
MeSH Terms
- Animals
- Atropine / administration & dosage
- Atropine / pharmacology
- Cardiotonic Agents / administration & dosage
- Cardiotonic Agents / pharmacology
- Dobutamine / administration & dosage
- Dobutamine / pharmacology
- Drug Therapy, Combination
- Echocardiography, Stress / veterinary
- Horses / physiology
- Infusions, Intravenous / veterinary
- Ventricular Function, Left / drug effects
Citations
This article has been cited 2 times.- Vitale V, Vezzosi T, Di Franco C, Briganti A, Tognetti R, Conte G, Bucchioni E, Sgorbini M. Equine echocardiography: Can dobutamine infusion correct alterations due to sedation with alpha-2 agonists?. PLoS One 2022;17(10):e0276256.
- Dufourni A, Buschmann E, Vernemmen I, Van Steenkiste G, van Loon G, Decloedt A. Effect of physiological and pharmacological stress on heart rate, blood pressure, and echocardiographic measurements in healthy Warmblood horses. J Vet Intern Med 2024 Jan-Feb;38(1):398-410.
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