Effect of eltenac in horses with induced endotoxaemia.
Abstract: Ten horses were used in a crossover study to evaluate the effectiveness of eltenac against endotoxaemia. Eltenac (0.5 mg/kg bwt) or saline control was given i.v. then 15 min later, intravenous infusion of endotoxin was begun and continued for 120 min (total dose 100 ng/kg bwt). Horses were monitored for heart and respiratory rates, pulmonary and carotid arterial pressure and core body temperature. Blood was sampled at intervals for measurement of haematological variables and plasma concentrations of lactate, prostanoid metabolites, tumour necrosis factor (TNF) and stress hormones. In comparison with saline-treatment, use of eltenac significantly protected against endotoxin-induced changes in respiratory rate, core temperature, systemic arterial blood pressure (SAP), pulmonary arterial pressure, PCV, and plasma protein, 6-keto prostaglandin F1 alpha, thromboxane B2, epinephrine, and cortisol concentrations. Despite statistical effect of eltenac on SAP, values in both treatment groups remained well above baseline throughout the evaluation period. Significant protective effect of eltenac was not found for heart rate, white blood cell count, plasma lactate concentration or TNF activity. On the basis of these results, it is expected that use of eltenac will provide clinical benefit in horses with naturally occurring endotoxaemia.
Publication Date: 2001-02-24 PubMed ID: 11202378DOI: 10.1111/j.2042-3306.2000.tb05330.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This study analyzed the effectiveness of the drug eltenac in treating endotoxaemia in horses, a condition caused by the presence of endotoxins in the blood. The results demonstrated that eltenac can significantly reduce symptoms of endotoxaemia, although it does not impact all related parameters.
Study Design
- The researchers conducted a crossover study on 10 horses. This type of study is defined by participants switching between treatment and control groups, allowing for a comparison of different outcomes within the same subjects.
- Each horse was administered either eltenac or a saline control. Following this, an endotoxin infusion was given to induce endotoxaemia.
- Key vitals such as heart rate, respiratory rate, pulmonary and carotid arterial pressure, and core body temperature were constantly monitored.
- In addition, blood samples were periodically taken for analysis of variables related to haematology and plasma concentrations of various substances including lactate, prostanoids, tumour necrosis factor (TNF), and stress hormones.
Findings
- Comparison between the drug and the saline administration showed that eltenac significantly minimized endotoxin-induced changes such as respiratory rate, core temperature, systemic arterial blood pressure, pulmonary arterial pressure, packed cell volume (PCV), and concentrations of certain plasma proteins and stress hormones.
- Interestingly, while eltenac showed has statistical effect on systemic arterial blood pressure, the blood pressure values with both treatments were above the baseline during the evaluation period.
- Eltenac did not show a significant protective effect on parameters such as heart rate, white blood cell count, plasma lactate concentration, or TNF activity.
Conclusions and Implications
- Based on the study findings, usage of eltenac could potentially offer clinical benefits to horses suffering from naturally occurring endotoxaemia.
- However, the protective effects of eltenac do not cover all aspects related to endotoxaemia. Therefore, further research is suggested for a comprehensive therapeutic approach.
Cite This Article
APA
MacKay RJ, Daniels CA, Bleyaert HF, Bailey JE, Gillis KD, Merritt AM, Katz TL, Johnson JC, Thompson KC.
(2001).
Effect of eltenac in horses with induced endotoxaemia.
Equine Vet J Suppl(32), 26-31.
https://doi.org/10.1111/j.2042-3306.2000.tb05330.x Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA.
MeSH Terms
- Aniline Compounds / administration & dosage
- Aniline Compounds / pharmacology
- Aniline Compounds / therapeutic use
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
- Anti-Inflammatory Agents, Non-Steroidal / pharmacology
- Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
- Bacterial Toxins
- Cross-Over Studies
- Endotoxemia / prevention & control
- Endotoxemia / veterinary
- Escherichia coli Infections / prevention & control
- Escherichia coli Infections / veterinary
- Horse Diseases / blood
- Horse Diseases / prevention & control
- Horses
- Injections, Intravenous / veterinary
- Plasma / drug effects
- Prostaglandins / blood
- Pulmonary Wedge Pressure / drug effects
- Random Allocation
- Respiration / drug effects
- Thiophenes / administration & dosage
- Thiophenes / pharmacology
- Thiophenes / therapeutic use
- Thromboxane B2 / blood
Citations
This article has been cited 2 times.- Anderson MJ, Ibrahim AS, Cooper BR, Woolcock AD, Moore GE, Taylor SD. Effects of administration of ascorbic acid and low-dose hydrocortisone after infusion of sublethal doses of lipopolysaccharide to horses. J Vet Intern Med 2020 Nov;34(6):2710-2718.
- Tian J, Chen ZC, Wu B, Meng X. Comparison of quality of life between urban and rural gastric cancer patients and analysis of influencing factors. World J Gastroenterol 2004 Oct 15;10(20):2940-3.
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