Effect of flunixin meglumine on endogenous prostaglandin F2 alpha secretion during cloprostenol-induced abortion in mares.
Abstract: To determine the relative role of endogenous prostaglandin F2 alpha (PGF2 alpha) secretion in cloprostenol-induced abortion in mares that no longer require luteal progesterone secretion for maintenance of pregnancy, and to evaluate the ability of a prostaglandin cyclooxygenase inhibitor (flunixin meglumine) to prevent cloprostenol-induced abortion. Methods: The effect of flunixin meglumine on PGF2 alpha secretion and outcome of pregnancy was compared between mares treated with cloprostenol only and mares treated with cloprostenol plus flunixin meglumine. Methods: Five pregnant mares, aged 4 to 15 years, of light-horse type. Methods: Cloprostenol (250 micrograms) was administered at 24-hour intervals to 5 pregnant mares. Flunixin meglumine (500 mg, IV) was administered at 8-hour intervals starting 15 minutes before the first cloprostenol administration. Hourly blood samples were analyzed for 15-ketodihydro-PGF2 alpha, progesterone, and estrogen concentrations. Previously reported data on cloprostenol-induced abortion in 6 pregnant mares treated daily with cloprostenol only were used as historic controls. Results: The mean (+/- SEM) interval from first cloprostenol administration to fetal expulsion 56.4 (+/- 13.7) hours and number of cloprostenol administrations 3.2 (+/- 0.6) in the 5 flunixin meglumine-treated mares were not significantly different, compared with values for 6 pregnant mares treated daily with cloprostenol only, 48.6 (+/- 5.6) hours and 2.8 (+/- 0.2) cloprostenol administrations. Flunixin meglumine did not inhibit endogenous PGF2 alpha secretion. Prostaglandin F2 alpha secretion rates on the day before and day of fetal expulsion were similar in both groups. Conclusions: Flunixin meglumine at a dosage of 500 mg/animal, administered IV every 8 hours, is ineffective in modulating uterine PGF2 alpha secretion during cloprostenol-induced abortion. Conclusions: Flunixin meglumine is ineffective in the modulation of prostaglandin-induced uterine PGF2 alpha secretion and, therefore, does not offer a viable alternative for the prevention of abortion in mares at risk of abortion because of systemic illness.
Publication Date: 1995-12-01 PubMed ID: 8599521
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research assesses the role of a natural substance (prostaglandin F2 alpha) in causing abortion in horses. It also examines whether a specific inhibitor (flunixin meglumine) can prevent this. The results reveal the inhibitor does not significantly impact the abortion process initiated by prostaglandin.
About the Study
- The study aimed to understand the role of endogenous prostaglandin F2 alpha (PGF2 alpha) in cloprostenol-induced abortion in mares, where the pregnancy doesn’t rely on luteal progesterone secretion for maintenance.
- In addition, it sought to evaluate the capability of flunixin meglumine—a prophylactic cyclooxygenase inhibitor—in preventing such abortions.
- For the study, both flunixin meglumine and cloprostenol were administered to pregnant mares. The results compared the outcome of pregnancy both with and without the inhibitor.
- Five mares aged between 4 and 15 years old were included in the study. Cloprostenol (250 micrograms) was administered every 24 hours and flunixin meglumine (500 mg, IV) was administered every 8 hours starting 15 minutes before the first cloprostenol administration. Blood samples were taken hourly and analyzed for various factors.
- The historic data was used as control, which consisted of six pregnant mares only treated with cloprostenol.
Findings
- The interval and number of cloprostenol administrations between the first cloprostenol administration to fetal expulsion was not significantly different in mares treated with only cloprostenol compared to those treated with cloprostenol and flunixin meglumine.
- Even with this inhibitor, the endogenous PGF2 alpha secretion was not suppressed. The secretion rates on the day before and the day of fetal expulsion were similar in both groups.
Conclusions
- The study concluded that flunixin meglumine, at a dose of 500 mg per animal, given intravenously every 8 hours, does not effectively modulate uterine PGF2 alpha secretion during cloprostenol-induced abortion.
- Flunixin meglumine thus doesn’t offer a feasible alternative for the prevention of abortion in mares at risk of abortion due to systemic illness.
Cite This Article
APA
Daels PF, Mohammed HO, Odensvik K, Kindahl H.
(1995).
Effect of flunixin meglumine on endogenous prostaglandin F2 alpha secretion during cloprostenol-induced abortion in mares.
Am J Vet Res, 56(12), 1603-1610.
Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
MeSH Terms
- Abortion, Induced / veterinary
- Animals
- Clonixin / analogs & derivatives
- Clonixin / pharmacology
- Cloprostenol
- Cyclooxygenase Inhibitors / pharmacology
- Dinoprost / antagonists & inhibitors
- Dinoprost / metabolism
- Dinoprost / physiology
- Estrogens / blood
- Estrogens / metabolism
- Female
- Horses / metabolism
- Pregnancy
- Pregnancy Outcome / veterinary
- Progesterone / blood
- Progesterone / metabolism
- Time Factors
Citations
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