Effect of frusemide and hypertonic saline on electrolytes during post exercise anaesthesia.
Abstract: This study evaluated the effects of pre-exercise frusemide administration and hypertonic saline (H) infusion during anaesthesia on arterial pH, blood gases and electrolytes in 6 Thoroughbred horses anaesthetised immediately post exercise. Horses received either frusemide (F) (0.5 mg/kg, i.v.) or a saline placebo (P) injection 4 h prior to treadmill exercise. Exercise consisted of a 3 min warm-up at 40% VO2max followed by exercise to fatigue. Detomidine (40 micrograms/kg, i.v.) was given within 5 min of stopping and followed 5 min later by zolazepam-tiletamine (1.25 mg/kg, i.v.) to induce anaesthesia. During maintenance of anaesthesia using isoflurane in O2, either isotonic saline solution (I) or 7.5% H (4 ml/kg, i.v.) was administered. Arterial blood was sampled at the following times: prior to (Pre-F/P) and 4 h after (Pre-ex) F or P administration, 1 min after fatigue (Fatigue), 5 min after induction of anaesthesia (Post-ind), and just prior to and 15, 30 and 60 min after beginning isoflurane (ISFL) anaesthesia. Arterial pH and blood gas tensions, pulmonary arterial blood temperature, plasma [lactate], total protein and plasma [Na+], [K+], and [Cl-] were measured. Data were analyzed using 2-way ANOVA for repeated measures (P < 0.05). There were significant differences over time for all variables except total protein. Plasma [Na+] increased at Fatigue compared to Pre-F/P or Pre-ex in all treatment groups. Plasma [Na+] and [Cl-] increased during ISFL anaesthesia compared to Pre-F/P and Pre-ex in horses given H. During ISFL anaesthesia, plasma [Cl-] decreased compared to Pre-F/P in Group F+I horses. We conclude that acid-base, blood gas, and electrolyte changes associated with F are unlikely to influence management of horses anaesthetised immediately following supramaximal exercise to fatigue. Hypertonic saline infusion may help restore plasma [Cl-] faster in hypochloraemic horses requiring anaesthesia immediately after strenuous exercise.
Publication Date: 2000-02-05 PubMed ID: 10659295DOI: 10.1111/j.2042-3306.1999.tb05261.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research investigated how frusemide, a diuretic medication, affected blood gases and electrolytes in horses that were anaesthetized after intense exercise. It also studied the impact of hypertonic saline infusion during anaesthesia. The results suggest that frusemide does not significantly change acid-base balance, blood gases, and electrolytes, but hypertonic saline infusion could help restore chloride in horses that need anaesthesia after strenuous exercise.
Methodology
- The study was performed on six Thoroughbred horses.
- 24 hours prior to exercise either frusemide or saline placebo was administered.
- The horses were then exercised to fatigue on a treadmill following a warm-up session.
- Anesthesia was induced within 5 minutes of stopping exercise using a combination of Detomidine and Zolazepam-tiletamine.
- During the intervention, they were cared for with isoflurane and oxygen therapy, and were administered either isotonic saline or 7.5% hypertonic saline.
- Arterial blood samples were drawn in the following stages: before and after the frusemide or placebo administration, just after fatigue, post-anesthesia induction, and at various intervals during anesthesia.
Findings
- Significant differences were observed in all variables except for total protein over time.
- Post fatigue, all treatment groups showed an increased level of plasma sodium compared to before administering frusemide/placebo and pre-exercise levels.
- Plasma sodium and chloride levels increased during isoflurane anesthesia in horses treated with hypertonic saline when compared to initial levels.
- A decrease in plasma chloride levels was noted during isoflurane anesthesia in the group of horses tapped with frusemide and isotonic saline compared to the initial values.
Conclusion
- The changes in acid-base balance, blood gases, and electrolytes associated with administering frusemide are not likely to affect the management of horses being anaesthetized immediately after strenuous exercise.
- Infusion of hypertonic saline during anesthesia may aid in quickly restoring plasma chloride levels in horses which undergo strenuous exercise just before anesthesia.
Cite This Article
APA
Greene S, Keegan R, Brown J, Kingston J, Bayly WM.
(2000).
Effect of frusemide and hypertonic saline on electrolytes during post exercise anaesthesia.
Equine Vet J Suppl(30), 434-437.
https://doi.org/10.1111/j.2042-3306.1999.tb05261.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, USA.
MeSH Terms
- Acid-Base Equilibrium / drug effects
- Anesthesia / veterinary
- Animals
- Diuretics / pharmacology
- Electrolytes / blood
- Female
- Furosemide / pharmacology
- Horses / physiology
- Male
- Oxygen Consumption
- Physical Conditioning, Animal
- Saline Solution, Hypertonic
- Sodium / blood
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