Effect of furosemide administration on systemic circulation of ponies during severe exercise.
Abstract: Systemic distribution of blood flow was studied in 11 healthy adult grade ponies, using radionuclide-labeled microspheres (15 micron diameter) that were injected into the left ventricle. Measurements were made at rest, during severe exercise (SE) without furosemide, as well as during SE at 10 minutes and 120 minutes after furosemide administration (1.0 mg/kg, IV). During SE, heart rate, cardiac output, mean aortic pressure, and whole body O2 consumption were 220 +/- 4 beats/min, 720 +/- 44 ml/min/kg, 169 +/- 4 mm of Hg, and 126 +/- 9 ml of O2/min/kg, respectively. With SE performed after furosemide administration, mean aortic pressure decreased from prefurosemide SE value (P less than 0.05), but heart rate, cardiac output, and whole body O2 consumption remained similar to values during SE without furosemide. During SE, blood flow to cerebellar gray matter, pons, and medulla oblongata increased despite marked hypocapnia, but in other regions of the brain, blood flow was unchanged. As arterial O2 content increased by 58% with SE, O2 delivery to all brain regions increased. With SE, adrenal gland blood flow increased, but intense vasoconstriction in the kidneys, spleen, pancreas, small intestine, and colon caused blood flow to plummet. During SE, blood flow in the diaphragm, gluteus medius, biceps femoris (muscles of propulsion), and triceps brachii muscles increased to a similar level, indicating that metabolic requirements of the diaphragm during exercise may not be less than those of other vigorously contracting muscles.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1986-06-01 PubMed ID: 3729141
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research work investigates the systemic circulation (overall blood flow) in ponies during intense exercise and the impact of the drug furosemide on this circulation. The study observed changes in heart rate, cardiac output, aortic pressure and oxygen consumption, along with alterations in blood flow to key body regions like the brain, adrenal gland, kidneys, and certain muscles.
Methodology
- Eleven adult grade ponies underwent a systemic blood flow study utilizing radionuclide-labeled microspheres that were injected into their left heart chamber (left ventricle).
- Data were gathered under a variety of conditions, such as at rest, during severe exercise (SE) without furosemide, and during SE at both 10 minutes and 120 minutes post furosemide administration (1.0 mg/kg via intravenous method).
Intense Exercise Effects
- During intense exercise, parameters such as heart rate, cardiac output (the amount of blood the heart pumps), mean aortic pressure, and total body oxygen consumption exhibited specific values showing an increased demand on the cardiovascular system.
- Blood flow to certain regions of the brain (cerebellar gray matter, pons, and medulla oblongata) increased despite significant hypocapnia (reduced carbon dioxide in the blood).
- An increase in arterial oxygen content by 58% during intense exercise resulted in increased oxygen delivery to all brain areas.
- There was increased blood flow to the diaphragm and certain muscles involved in locomotion, suggesting their high metabolic demand during exercise.
- However, there was intense vasoconstriction (narrowing of blood vessels) in organs including kidneys, spleen, pancreas, small intestine, and colon, leading to reduced blood flow.
Impact of Furosemide
- Furosemide, a diuretic drug, caused a decrease in the mean aortic pressure from its prefurosemide exercise value, indicating its effect on blood pressure.
- Despite this, heart rate, cardiac output, and total body oxygen consumption during severe exercise remained comparable to their values without furosemide administration – suggesting that the drug did not significantly affect these parameters.
Note: The abstract was truncated, meaning the full range of results and their implications may not be fully discussed.
Cite This Article
APA
Manohar M.
(1986).
Effect of furosemide administration on systemic circulation of ponies during severe exercise.
Am J Vet Res, 47(6), 1387-1394.
Publication
Researcher Affiliations
MeSH Terms
- Adrenal Glands / blood supply
- Animals
- Blood Circulation / drug effects
- Cerebrovascular Circulation / drug effects
- Furosemide / pharmacology
- Hemodynamics / drug effects
- Horses / physiology
- Kidney / blood supply
- Muscles / blood supply
- Oxygen Consumption
- Physical Exertion
- Splanchnic Circulation / drug effects
Citations
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