Effect of hydroxyethyl starch solution in normal horses and horses with colic or acute colitis.
Abstract: Hydroxyethyl starch (HES) solution is an effective colloidal infusion solution in humans for treatment of hypovolaemic shock, but it has not been compared with fluids currently available for use in horses. On the basis of plasma-expanding effect of HES in normal horses, a 10% medium-molecular 200/0.5 solution of HES was subsequently tested in hypovolaemic horses. Six normal horses were given five protocols of a single infusion of HES at varying dosage rates (5, 10, 15 ml HES/kg), as well as isotonic saline (15 ml/kg) and hypertonic saline (4 ml/kg b.w.). Dehydrated horses suffering from acute colitis or those which had been treated surgically for ileus of the small or large intestine were given an i.v. infusion of 10 ml HES/kg in combination with 10 ml saline/kg. Clinical data and blood samples for testing were taken before the infusion, and then 10 min, 1 h, 2, 4, 6, 8, 10, 12 and 24 h after infusion (a.i.). A significant decrease in haematocrit was observed in protocol 1-5 for a period of up to 4, 4, 10 h, 10 min and up to 10 min; in group of colitis, during the entire 24-h testing period, and in groups of ileus of small intestine and of large intestine, up to 4 and 10 h a.i. HES decreases better and longer-lasting haematocrit and total protein than either isotonic or hypertonic saline. Half-life of HES increases due to higher dosage (5.83, 7.63 and 11.48 h) and distribution is exclusively intravascular. In normal horses of protocol 1-3 using HES aPTT, sodium and potassium were within the physiological range. Serum amylase activity is increased in horses using HES. On the basis of this clinical study, the decreasing effect of urea and creatinine in colic patients after surgery and fewer instances of postoperative ileus a dosage of 10 ml HES/kg could be recommended.
Publication Date: 2007-11-30 PubMed ID: 18045345DOI: 10.1111/j.1439-0442.2007.01007.xGoogle Scholar: Lookup
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Summary
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This research explores the effect of hydroxyethyl starch (HES) solution in hypovolaemic horses and those suffering from acute colitis, comparing its effectiveness with isotonic and hypertonic saline solutions. The study indicates that HES provides better and longer-lasting treatment results compared to the saline solutions.
Study Overview
- The researchers tested a 10% medium-molecular 200/0.5 solution of Hydroxyethyl Starch (HES) in normal horses and in hypovolaemic horses undergoing different treatment scenarios.
- The experimental dosage rates varied in five categories starting at 5 ml HES/KG up to 15 ml HES/Kg. Isotonic saline (15 ml/kg) and hypertonic saline (4 ml/kg b.w.) were the control treatments.
- The test subjects involved horses suffering from dehydration due to acute colitis or previously operated for ileus.
Methodology
- Horses were given an intravenous (i.v.) infusion of 10 ml HES/kg coupled with 10 ml saline/kg. This was then followed by a series of clinical examinations and blood workups before the infusion, and at several intervals up to 24 hours after infusion.
- The researchers closely monitored changes in haematocrit and total protein levels in the blood during this period.
Findings
- Significant decrease in haematocrit was observed in the five HES dosage protocols, colitis, and ileus groups after the infusion.
- HES pleasantly provided better and lasting haematocrit and total protein results than either isotonic or hypertonic saline solutions.
- Findings also observed an increase in the half-life of HES display based on the higher dosage rates. Distribution was found to be strictly intravascular.
- In normal horses using HES, some blood parameters like aPTT, sodium and potassium remained within the physiological range.
- However, the activity of serum amylase was found to be increased in horses using HES.
Conclusion
- Based on the findings from this study, the report recommends the application of HES at a dosage of 10 ml/kg for hypovolaemic horses or those suffering postoperative ileus since it effectively reduces urea and creatinine levels compared to other available treatment fluids.
Cite This Article
APA
Schusser GF, Rieckhoff K, Ungemach FR, Huskamp NH, Scheidemann W.
(2007).
Effect of hydroxyethyl starch solution in normal horses and horses with colic or acute colitis.
J Vet Med A Physiol Pathol Clin Med, 54(10), 592-598.
https://doi.org/10.1111/j.1439-0442.2007.01007.x Publication
Researcher Affiliations
- Department of Large Animal Medicine, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 11, 04103 Leipzig, Germany. schusser@vmf.uni-leipzig.de
MeSH Terms
- Animals
- Colic / drug therapy
- Colic / veterinary
- Colitis / drug therapy
- Colitis / veterinary
- Dose-Response Relationship, Drug
- Female
- Hemodynamics / drug effects
- Horse Diseases / drug therapy
- Horses
- Hydroxyethyl Starch Derivatives / therapeutic use
- Infusions, Intravenous / veterinary
- Male
- Plasma Substitutes / therapeutic use
- Saline Solution, Hypertonic
- Time Factors
- Treatment Outcome
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