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Open veterinary journal2019; 9(3); 273-280; doi: 10.4314/ovj.v9i3.14

Effect of inbreeding on the “Club Foot” disorder in Arabian Pureblood horses reared in Italy.

Abstract: "The Club Foot" (or "Mismatched Foot") is an acquired or congenital flexural deformity of the distal interphalangeal joint, caused by a shortening of the musculotendinous unit of the deep digital flexor tendon. The aim of this research was to detect the incidence of the disorder in Arabian Pureblood horses, attempting to understand its causes and to analyze a possible role of inbreeding in its expression. In this breed, in fact, the pathology is widespread because in the environment of origin, the rocky desert, a hard and almost goat's hoof is not disabling so the selection against this disorder has never been done. Pedigrees were taken from 141 (reference population = RP) adult Arabian Pureblood horses (51 males and 90 females) belonging to eight Italian different farms during the period 1982-2017. For each horse, the presence or not of the disorder was observed and inbreeding coefficients () was performed. Four grades of deformity were considered. Moreover, the environmental condition of each farm was considered: boxes, paddocks, nutrition, orientation, and hoof care and shoeing. The chi-square test was applied. Analysis of variance (ANOVA) was used to test the differences in the average inbreeding coefficient () between affected and healthy animals, between sexes and between shod and unshod animals. Two grades of deformity were observed (I and II) which give less severe manifestations, with 28 females and 25 males (37.59% of the examined horses) showing the disorder. No differences between males and females or between shod (38.29%) and unshod (61.70%) were observed. Environmental conditions do not influence the rate of pathology in the different farms, with a prevalence of the disorder ranging from 7.69% up to 100% on farm. The whole population (WP = RP and its genealogy) included 3,355 records subdivided in seven traced generations. One hundred and eighteen out of 141 horses (RP) were inbred (83.69%). The average inbreeding coefficient () in the RP was 0.095. Inbreeding coefficient in RP was 0.25 in 28 horses (23.73% of inbred). High inbreeding coefficients were observed in all farms and in particularly in affected animals suggesting that high inbreeding coefficients increases the probability that the disorder occurs. Future works may include the study of the hereditability of the character, and the attempt to identify loci associated with the disorder.
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Publication Date: 2019-09-29 PubMed ID: 31998623PubMed Central: PMC6794396DOI: 10.4314/ovj.v9i3.14Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research analyzes the presence of the “Club Foot” disorder in Arabian Pureblood horses in Italy, with a focus on understanding if inbreeding contributes to the condition’s incidence.

What is “Club Foot” disorder?

The “Club Foot” disorder, also referred to as “Mismatched Foot”, is an acquired or congenital deformity of the distal interphalangeal joint. It’s caused by a shortening of the musculotendinous unit of the deep digital flexor tendon. This deformity is commonly seen in Arabian Pureblood horses, particularly because in their original habitat, the rocky desert, a harder, goat-like hoof is not considered a disability. Therefore, active selection against this disorder never occurred.

Research Methodology

  • To carry out the research, data was collected from 141 adult Arabian Pureblood horses (51 males and 90 females) across eight different farms in Italy during the period of 1982-2017.
  • The team recorded the presence or absence of the disorder and calculated inbreeding coefficients for each horse.
  • Four levels of deformity were considered, however, only two less severe levels (I and II) were observed in the studied population.
  • The researchers also took into account the environmental conditions on each farm including stabling, nutrition, orientation, and hoof care and shoeing.
  • To analyze the data collected, the team employed a chi-square test and conducted an Analysis of Variance (ANOVA) to test for differences in the average inbreeding coefficient between affected and healthy animals, between sexes, and between shod and unshod animals.

Key Findings

It was observed that 37.59% of the evaluated horses showed the disorder, with no significant differences between males and females, or between shod (38.29%) and unshod (61.70%) horses. The findings also indicated that environmental conditions did not significantly influence the pathology rate on different farms where the incidence of the disorder ranged from 7.69% to 100%.

Researchers found that 83.69% of the horses (118 out of 141) were inbred. The average inbreeding coefficient (f) in the population was 0.095. Of the inbred horses, 12.71% had an inbreeding coefficient of less than 0.05, and 23.73% had a coefficient greater than 0.25. It was noted that farms with a high proportion of affected animals typically had higher inbreeding coefficients.

Conclusions and Future Research

The study concluded that inbreeding might contribute to a higher probability of “Club Foot” disorder in Arabian Pureblood horses. However, additional research is recommended, which could include studying the heritability of the character, as well as identifying any genetic loci associated with the disorder.

Cite This Article

APA
Comparini L, Podestà A, Russo C, Cecchi F. (2019). Effect of inbreeding on the “Club Foot” disorder in Arabian Pureblood horses reared in Italy. Open Vet J, 9(3), 273-280. https://doi.org/10.4314/ovj.v9i3.14

Publication

Open veterinary journal
ISSN: 2218-6050
NlmUniqueID: 101653182
Country: Libya
Language: English
Volume: 9
Issue: 3
Pages: 273-280

Researcher Affiliations

Comparini, Lisa
  • Department of Veterinary Science, University of Pisa, Pisa, Italy.
Podestà, Adriano
  • Department of Veterinary Science, University of Pisa, Pisa, Italy.
Russo, Claudia
  • Department of Veterinary Science, University of Pisa, Pisa, Italy.
Cecchi, Francesca
  • Department of Veterinary Science, University of Pisa, Pisa, Italy.

MeSH Terms

  • Animals
  • Clubfoot / epidemiology
  • Clubfoot / genetics
  • Clubfoot / veterinary
  • Female
  • Hoof and Claw / pathology
  • Horse Diseases / epidemiology
  • Horse Diseases / genetics
  • Horses
  • Inbreeding
  • Incidence
  • Italy / epidemiology
  • Male
  • Prevalence

Conflict of Interest Statement

The authors declare that there is no conflict of interest.

References

This article includes 30 references
  1. Avdi M, Banos G. Genetic diversity and inbreeding in the Greek Skyros horse. Livest. Sci. 2008;114:362–365.
  2. Brzeski KE, Rabon DR Jr, Chamberlain MJ, Waits LP, Taylor SS. Inbreeding and inbreeding depression in endangered red wolves (Canis rufus).. Mol Ecol 2014 Sep;23(17):4241-55.
    pubmed: 25060763doi: 10.1111/mec.12871google scholar: lookup
  3. Budzyński M, Kamieniak J, Chmiel K, Soltys L. Inbreeding coefficients of purebred Arabian horses from Michałów Stud. Annales Universitatis Mariae Curie-Skłodowska Lublin 1997;21:141–147.
  4. Bussiman FO, Perez BC, Ventura RV, Peixoto MGCD, Curi RA, Balieiro JCC. Pedigree analysis and inbreeding effects over morphological traits in Campolina horse population.. Animal 2018 Feb 22;:1-10.
    pubmed: 29467044doi: 10.1017/s175173111800023xgoogle scholar: lookup
  5. Cecchi F, Giacalone G, Paci G. Inbreeding depression in Lizard canaries breed estimated by pedigree analysis. Czech J. Anim. Sci. 2016;61:15–21.
  6. Cecchi F, Carlini G, Giuliotti L, Russo C. Inbreeding may affect phenotypic traits in an Italian Population of Basset Hound dog. Rend. Lincei Sci. Fis. Nat. 2018;29:165–170.
  7. Cervantes I, Goyache F, Molina A, Valera M, Gutiérrez JP. Application of individual increase in inbreeding to estimate realized effective sizes from real pedigrees.. J Anim Breed Genet 2008 Oct;125(5):301-10.
    pubmed: 18803785doi: 10.1111/j.1439-0388.2008.00755.xgoogle scholar: lookup
  8. Ciampolini R, Cecchi F, Paci G, Policardo C, Spaterna A. Investigation on the Genetic Variability of the American Pit Bull Terrier dogs belonging to an Italian breeder using Microsatellite Markers and genealogical data. Cytol. Genet. 2013;47(4):217–221.
  9. Curik I, Zechner P, Sölkner J, Achmann R, Bodo I, Dovc P, Kavar T, Marti E, Brem G. Inbreeding, microsatellite heterozygosity, and morphological traits in Lipizzan horses.. J Hered 2003 Mar-Apr;94(2):125-32.
    pubmed: 12721224doi: 10.1093/jhered/esg029google scholar: lookup
  10. Dolvik N.I, Klemetsdal G. Arthritis in the carpal joints of Norwegian trotter — heritability, effects of inbreeding and conformation. Livest. Prod. Sci. 1994;39:283–290.
  11. Gandini G.C, Bagnato A, Miglior F, Pagnacco G. Inbreeding in the Italian Haflinger horse. J. Anim. Breed. Genet. 1992;109:433–443.
  12. Głażewska I. Mating and selection in national Arabian horse breeding: inbreeding coefficients analysis. Electron J Polish Agric Univ. 2004;7(1).
  13. Gómez M.D, Valera M, Molina A, Gutiérrez J.P, Goyache F. Assessment of inbreeding depression for body measurements in Spanish Purebred (Andalusian) horses. Livest. Sci. 2009;122:149–155.
  14. González-Recio O, López de Maturana E, Gutiérrez JP. Inbreeding depression on female fertility and calving ease in Spanish dairy cattle.. J Dairy Sci 2007 Dec;90(12):5744-52.
    pubmed: 18024768doi: 10.3168/jds.2007-0203google scholar: lookup
  15. Gutiérrez JP, Goyache F. A note on ENDOG: a computer program for analysing pedigree information.. J Anim Breed Genet 2005 Jun;122(3):172-6.
    pubmed: 16130468doi: 10.1111/j.1439-0388.2005.00512.xgoogle scholar: lookup
  16. Hunt R.J. Flexural limb deformities in foals. In: Ross M.W, Dyson S.J, editors. Diagnosis and management of lameness in the horse. 2nd. Philadelphia: W.B. Saunders; 2011. pp. 645–649.
  17. Keller L.F, Waller D.M. Inbreeding effects in wild populations. Trends Ecol. Evol. 2002;17:230–241.
  18. Langlois B, Blouin C. Statistical analysis of some factors affecting the number of horse births in France.. Reprod Nutr Dev 2004 Nov-Dec;44(6):583-95.
    pubmed: 15762302doi: 10.1051/rnd:2004055google scholar: lookup
  19. O'Grady SE, Poupard DA. Proper physiologic horseshoeing.. Vet Clin North Am Equine Pract 2003 Aug;19(2):333-51.
    pubmed: 14575163doi: 10.1016/s0749-0739(03)00020-8google scholar: lookup
  20. O’Grady S.E. Flexure Deformities of the distal interphalangeal jount (cl뿮t). Equine Vet. Educ. 2012;5:260–268.
  21. Redden RF. Hoof capsule distortion: understanding the mechanisms as a basis for rational management.. Vet Clin North Am Equine Pract 2003 Aug;19(2):443-62.
    pubmed: 14575168doi: 10.1016/s0749-0739(03)00027-0google scholar: lookup
  22. Sairanen J, Nivola K, Katila T, Virtala AM, Ojala M. Effects of inbreeding and other genetic components on equine fertility.. Animal 2009 Dec;3(12):1662-72.
    pubmed: 22443550doi: 10.1017/s1751731109990553google scholar: lookup
  23. SAS-JMP. User’s Guide, ver. Cary. NC: 7.0 SAS Inst; 2007.
  24. Sargolzaei M, Iwaisaki H, Colleau J.J. CFC (Contribution, Inbreeding (F)), Coancestry, Release 1.0. A software package for pedigree analysis and monitoring genetic diversity. Proc. 8th world cong. on genetics applied on livestock production; Belo Horizonte, Brazil 2006. CD-ROM comm. N 27–28.
  25. Schiele E. The Arab Horse in Europe. London, UK: George G. Harrap & CO; 1970.
  26. Sierszchulski J, Helak M, Wolc A, Szwaczkowski T, Schlote W. Inbreeding rate and its effect on some conformation traits in Arabian mares. Anim. Sci. Pap. Rep. 2005;23:51–59.
  27. Sobczyńska M. Genetic parameters of racing performance indices in Polish Arabian horses. Livest. Sci. 2010;131:245–249.
  28. Todd ET, Ho SYW, Thomson PC, Ang RA, Velie BD, Hamilton NA. Founder-specific inbreeding depression affects racing performance in Thoroughbred horses.. Sci Rep 2018 Apr 18;8(1):6167.
    pmc: PMC5906619pubmed: 29670190doi: 10.1038/s41598-018-24663-xgoogle scholar: lookup
  29. Vostrá-Vydrová H, Vostrý L, Hofmanová B, Krupa E, Zavadilová L. Pedigree analysis of the endangered Old Kladruber horse population. Livest. Sci. 2016;185:17–23.
  30. Wolc A, Balińska K. Inbreeding effects on exterior traits in Polish konik horses. Arch. Tierz. 2010;53:1–8.

Citations

This article has been cited 7 times.
  1. Murakami S, Shimada M, Hara Y. Partial tarsal arthrodesis with closing wedge ostectomy for treatment of bilateral twisted leg deformity in a cat. Can Vet J 2023 Sep;64(9):823-827.
    pubmed: 37663030
  2. Ludwig EK, Hallowell K, Womble M, O'Neil E. Bilateral patellar aplasia in a foal. Vet Med Sci 2023 May;9(3):1143-1148.
    doi: 10.1002/vms3.1083pubmed: 36734120google scholar: lookup
  3. Cardinali I, Giontella A, Tommasi A, Silvestrelli M, Lancioni H. Unlocking Horse Y Chromosome Diversity. Genes (Basel) 2022 Dec 2;13(12).
    doi: 10.3390/genes13122272pubmed: 36553539google scholar: lookup
  4. Próchniak T, Kasperek K, Knaga S, Rozempolska-Rucińska I, Batkowska J, Drabik K, Ziȩba G. Pedigree Analysis of Warmblood Horses Participating in Competitions for Young Horses. Front Genet 2021;12:658403.
    doi: 10.3389/fgene.2021.658403pubmed: 33936176google scholar: lookup
  5. Poyato-Bonilla J, Perdomo-González DI, Sánchez-Guerrero MJ, Varona L, Molina A, Casellas J, Valera M. Genetic inbreeding depression load for morphological traits and defects in the Pura Raza Española horse. Genet Sel Evol 2020 Oct 20;52(1):62.
    doi: 10.1186/s12711-020-00582-2pubmed: 33081691google scholar: lookup
  6. Ripolles M, Sánchez-Guerrero MJ, Perdomo-González DI, Azor P, Valera M. Survey of Risk Factors and Genetic Characterization of Ewe Neck in a World Population of Pura Raza Español Horses. Animals (Basel) 2020 Oct 1;10(10).
    doi: 10.3390/ani10101789pubmed: 33019702google scholar: lookup
  7. Cellai S, Gazzano A, Casini L, Gazzano V, Cecchi F, Macchioni F, Cozzi A, Pageat L, Arroub S, Fratini S, Felici M, Curadi MC, Baragli P. The Memory Abilities of the Elderly Horse. Animals (Basel) 2024 Oct 25;14(21).
    doi: 10.3390/ani14213073pubmed: 39518796google scholar: lookup
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